{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:59:38Z","timestamp":1791561578831,"version":"4.3.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Boston Scientific International"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Leg ulcers are common, costly, and significantly impair quality of life, but their management is variable and associated with considerable delays in healing. The aim of this study was to design an accelerated leg ulcer care pathway in a community and hospital setting to improve patient outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A new referral pathway was developed using a series of healthcare professional and patient interviews, focus groups, and stakeholder workshops. The referral pathway, investigation and treatment protocols were further informed by clinical guidelines to develop the Leg Ulcer Pathway Acceleration care pathway. The outcomes of a consecutive series of patients enrolled in the Leg Ulcer Pathway Acceleration care pathway were compared with the outcomes of patients from a historical leg ulcer cohort from the same community and hospital setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 110 eligible patients were enrolled and followed prospectively through the Leg Ulcer Pathway Acceleration care pathway. Their outcomes were compared with those of 183 patients with venous leg ulcers identified from existing hospital and community ulcer centres, and acting as the historical control group. The 110 patients in the Leg Ulcer Pathway Acceleration group consisted of 73 (66 per cent) men, had a mean(s.d.) age of 55.7(17.2) years, and had a median initial ulcer duration of 14.5 (i.q.r. 6\u201330) months. The 183 patients in the historical control group consisted of 119 (65 per cent) men, had a mean(s.d.) age of 56.4(17.2) years, and had a median initial ulcer duration of 13.5 (i.q.r. 6\u201347) months. Venous disease was treated in 67\/110 (61 per cent) and deep venous disease was treated in 33\/110 (30 per cent) of patients in the Leg Ulcer Pathway Acceleration cohort. In contrast, only 16\/183 (8 per cent) of patients in the control group were treated for superficial venous insufficiency and 4\/183 (2 per cent) of patients in the control group were treated for deep venous disease. Ulcer healing rates at 12 months were 80 and 20 per cent in the Leg Ulcer Pathway Acceleration group and the control group respectively (P &amp;lt; 0.001). Adjusted for baseline characteristics, the OR for a healed ulcer at 12 months was 21.21 (95 per cent c.i.. 11.32 to 42.46) (P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The introduction of an accelerated leg ulcer care pathway significantly improves ulcer healing when compared with historical controls.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znad088","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T13:59:49Z","timestamp":1682776789000},"page":"797-803","source":"Crossref","is-referenced-by-count":4,"title":["Leg Ulcer Pathway Acceleration (LUPA) study"],"prefix":"10.1093","volume":"110","author":[{"given":"Vanessa","family":"Livingstone","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Guy\u2019s and St Thomas\u2019 Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Guy\u2019s and St Thomas\u2019 Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujith","family":"Peta","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Guy\u2019s and St Thomas\u2019 Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeb","family":"Mengtsu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Guy\u2019s and St Thomas\u2019 Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Guy\u2019s and St Thomas\u2019 Hospital , London , 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