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Despite broad adoption, electrochemotherapy implementation is hindered by a lack of treatment indications, uncertainty regarding procedural aspects, and the absence of quality indicators. An expert consensus may harmonize the approach among centres and facilitate comparison with other therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An interdisciplinary panel was recruited for a three-round e-Delphi survey. A literature-based 113-item questionnaire was proposed to 160 professionals from 53 European centres. Participants rated each item for relevance and degree of agreement on a five-point Likert scale, and received anonymous controlled feedback to allow revision. The items that reached concordant agreement in two successive iterations were included in the final consensus list. In the third round, quality indicator benchmarks were defined using a real-time Delphi method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial working group included 122 respondents, of whom 100 (82 per cent) completed the first round, thus qualifying for inclusion in the expert panel (49 surgeons, 29 dermatologists, 15 medical oncologists, three radiotherapists, two nurse specialists, two clinician scientists). The completion rate was 97 per cent (97 of 100) and 93 per cent (90 of 97) in the second and third rounds respectively. The final consensus list included 54 statements with benchmarks (treatment indications, (37); procedural aspects, (1); quality indicators, (16)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An expert panel achieved consensus on the use of electrochemotherapy in melanoma, with a core set of statements providing general direction to electrochemotherapy users to refine indications, align clinical practices, and promote quality assurance programmes and local audits. The residual controversial topics set future research priorities to improve patient care.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bjs\/znad105","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T05:11:46Z","timestamp":1683090706000},"page":"818-830","source":"Crossref","is-referenced-by-count":8,"title":["European e-Delphi process to define expert consensus on electrochemotherapy treatment indications, procedural aspects, and quality indicators in melanoma"],"prefix":"10.1093","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-8459","authenticated-orcid":false,"given":"Luca G","family":"Campana","sequence":"first","affiliation":[{"name":"Department of Surgery, Manchester University NHS Foundation Trust , Manchester , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Farronato","sequence":"additional","affiliation":[{"name":"Institute of General Practice, College of Health Care Professions Claudiana , Bolzano\/Bozen , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Hodgetts","sequence":"additional","affiliation":[{"name":"Medical Oncology, Christie NHS Foundation Trust , Manchester , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Odili","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, St George\u2019s Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Vecchiato","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Veneto Institute of Oncology, IOV-IRCCS , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Bracken","sequence":"additional","affiliation":[{"name":"Cork Cancer Research Centre , Cork , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Baier","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Azienda Sanitaria dell\u2019Alto Adige , Bolzano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk G","family":"Bechara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology, St Josef Hospital, Ruhr University , Bochum , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Borgognoni","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Unit, Department of Surgery, Santa Maria Annunziata Hospital , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Carac\u00f2","sequence":"additional","affiliation":[{"name":"Division of Surgery of Melanoma and Skin Cancer, Istituto Nazionale Tumori-IRCCS Fondazione \u2018G. 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