{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:36:45Z","timestamp":1793047005556,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The Scandinavian Diverticulitis (SCANDIV) trial and the LOLA arm of the LADIES trial randomized patients with Hinchey III perforated diverticulitis to laparoscopic peritoneal lavage or sigmoid resection. The aim of this analysis was to identify risk factors for treatment failure in patients with Hinchey III perforated diverticulitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a post hoc analysis of the SCANDIV trial and LOLA arm. Treatment failure was defined as morbidity requiring general anaesthesia (Clavien\u2013Dindo grade IIIb or higher) within 90 days. Age, sex, BMI, ASA fitness grade, smoking status, previous episodes of diverticulitis, previous abdominal surgery, time to surgery, and surgical competence were all tested in univariable and multivariable logistic regression analyses using an interaction variable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The pooled analysis included 222 patients randomized to laparoscopic lavage and primary resection (116 and 106 patients respectively). Univariable analysis found ASA grade to be associated with advanced morbidity in both groups, and the following factors in the laparoscopic lavage group: smoking, corticosteroid use, and BMI. Significant factors for laparoscopic lavage morbidity in multivariable analysis were smoking (OR 7.05, 95 per cent c.i. 2.07 to 23.98; P = 0.002) and corticosteroid use (OR 6.02, 1.54 to 23.51; P = 0.010).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Active smoking status and corticosteroid use were risk factors for laparoscopic lavage treatment failure (advanced morbidity) in patients with perforated diverticulitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znad114","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:17:16Z","timestamp":1684469836000},"page":"846-851","source":"Crossref","is-referenced-by-count":6,"title":["Laparoscopic lavage for Hinchey III perforated diverticulitis: factors for treatment failure in two randomized clinical trials"],"prefix":"10.1093","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-4441","authenticated-orcid":false,"given":"Najia","family":"Azhar","sequence":"first","affiliation":[{"name":"Department of Surgery, Sk\u00e5ne University Hospital , Malm\u00f6 , Sweden"},{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-3115","authenticated-orcid":false,"given":"Dani\u00ebl","family":"Lambrichts","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus University Medical Centre , Rotterdam , The Netherlands"},{"name":"Department of Surgery, University Medical Centre Amsterdam, AMC , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus University Medical Centre , Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheraz","family":"Yaqub","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , Oslo , Norway"},{"name":"Department of Gastrointestinal Surgery, Oslo University Hospital , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"\u00d8resland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schultz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , Oslo , Norway"},{"name":"Department of Digestive Surgery, Akershus University Hospital , L\u00f8renskog , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Centre Amsterdam, AMC , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-5552","authenticated-orcid":false,"given":"Pamela","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sk\u00e5ne University Hospital , Malm\u00f6 , Sweden"},{"name":"Department of Clinical Sciences Malm\u00f6, Lund University , Malm\u00f6 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"2023063011041258400_znad114-B1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/ajg.2015.302","article-title":"Temporal trends in the incidence and natural history of diverticulitis: a population-based 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