{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:53:45Z","timestamp":1769572425259,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KWF Dutch Cancer Society"},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Active surveillance is being investigated as an alternative to standard surgery after neoadjuvant chemoradiotherapy for oesophageal cancer. It is unknown whether dysphagia persists or develops when the oesophagus is preserved after neoadjuvant chemoradiotherapy. The aim of this study was to assess the prevalence and severity of dysphagia during active surveillance in patients with an ongoing response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients who underwent active surveillance were identified from the Surgery As Needed for Oesophageal cancer (\u2018SANO\u2019) trial. Patients without evidence of residual oesophageal cancer until at least 6 months after neoadjuvant chemoradiotherapy were included. Study endpoints were assessed at time points that patients were cancer-free and remained cancer-free for the next 4 months. Dysphagia scores were evaluated at 6, 9, 12, and 16 months after neoadjuvant chemoradiotherapy. Scores were based on the European Organisation for Research and Treatment of Cancer oesophago-gastric quality-of-life questionnaire 25 (EORTC QLQ-OG25) (range 0\u2013100; no to severe dysphagia). The rate of patients with a (non-)traversable stenosis was determined based on all available endoscopy reports.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 131 patients were included, of whom 93 (71.0 per cent) had adenocarcinoma, 93 (71.0 per cent) had a cT3\u20134a tumour, and 33 (25.2 per cent) had a tumour circumference of greater than 75 per cent at endoscopy; 60.8 to 71.0 per cent of patients completed questionnaires per time point after neoadjuvant chemoradiotherapy. At all time points after neoadjuvant chemoradiotherapy, median dysphagia scores were 0 (interquartile range 0\u20130). Two patients (1.5 per cent) underwent an intervention for a stenosis: one underwent successful endoscopic dilatation; and the other patient required temporary tube feeding. Notably, these patients did not participate in questionnaires.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Dysphagia and clinically relevant stenosis are uncommon during active surveillance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znad211","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T17:00:09Z","timestamp":1688749209000},"page":"1381-1386","source":"Crossref","is-referenced-by-count":8,"title":["Active surveillance of oesophageal cancer after response to neoadjuvant chemoradiotherapy: dysphagia is uncommon"],"prefix":"10.1093","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-9568","authenticated-orcid":false,"given":"Maria J","family":"Valkema","sequence":"first","affiliation":[{"name":"Department of Surgery, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-9757","authenticated-orcid":false,"given":"Manon C W","family":"Spaander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurjen J","family":"Boonstra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Centre , Leiden , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanda M","family":"van Dieren","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, The Netherlands Cancer Institute , Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter L","family":"Hazen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Elisabeth Tweesteden Hospital , Tilburg , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G Willemien","family":"Erkelens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gelre Hospital , Apeldoorn , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Lisanne","family":"Holster","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Maasstad Hospital , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andries","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zorggroep Twente , Almelo , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaas","family":"van der Linde","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical Centre Leeuwarden , Leeuwarden , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liekele E","family":"Oostenbrug","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zuyderland Medical Centre , Heerlen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rutger","family":"Quispel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Reinier de Graaf Group , Delft , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik J","family":"Schoon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Catharina Hospital Eindhoven , Eindhoven , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D","family":"Siersema","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Radboud Institute for Health Sciences , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Doukas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-596X","authenticated-orcid":false,"given":"Ben M","family":"Eyck","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-0628","authenticated-orcid":false,"given":"Berend J","family":"van der Wilk","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter C","family":"van der Sluis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4738-3697","authenticated-orcid":false,"given":"Bas P L","family":"Wijnhoven","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoerd M","family":"Lagarde","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC Cancer Institute , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Jan B","family":"van Lanschot","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC Cancer Institute , Rotterdam , The 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