{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:15:25Z","timestamp":1789046125963,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Vasternorrland County Council","award":["LVNFOU834401"],"award-info":[{"award-number":["LVNFOU834401"]}]},{"name":"Vasterbotten County Council"},{"name":"Swedish Breast Cancer Society"},{"DOI":"10.13039\/100018650","name":"Percy Falk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018650","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Visare Norr","award":["931408"],"award-info":[{"award-number":["931408"]}]},{"name":"Visare Norr","award":["968146"],"award-info":[{"award-number":["968146"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Breast angiosarcoma is a rare disease mostly observed in breast cancer (BC) patients who have previously received radiotherapy (RT). Little is known about angiosarcoma aetiology, management, and outcome. The study aim was to estimate risk and to characterize breast angiosarcoma in a Swedish population-based cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Swedish Cancer Registry was searched for breast angiosarcoma between 1992 and 2018 in three Swedish healthcare regions (population 5.5 million). Information on previous BC, RT, management, and outcome were retrieved from medical records.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 49 angiosarcomas located in the breast, chest wall, or axilla were identified, 8 primary and 41 secondary to BC treatment. Median age was 51 and 73 years, respectively. The minimum latency period of secondary angiosarcoma after a BC diagnosis was 4 years (range 4\u201321 years). The cumulative incidence of angiosarcoma after breast RT increased continuously, reaching 1.4\u2030 after 20 years. Among 44 women with angiosarcoma treated by surgery, 29 developed subsequent local recurrence. Median recurrence-free survival was 3.4 and 1.8 years for primary and secondary angiosarcoma, respectively. The 5-year overall survival probability for the whole cohort was 50 per cent (95 per cent c.i., 21 per cent\u2013100 per cent) for primary breast angiosarcoma and 35 per cent (95 per cent c.i., 23 per cent\u201354 per cent) for secondary angiosarcoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Breast angiosarcoma is a rare disease strongly associated with a history of previous BC RT. Overall survival is poor with high rates of local recurrences and distant metastasis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znad290","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:07:29Z","timestamp":1694729249000},"page":"1850-1856","source":"Crossref","is-referenced-by-count":9,"title":["Angiosarcoma in the breast: a population-based cohort from Sweden"],"prefix":"10.1093","volume":"110","author":[{"given":"Susanne","family":"Olander","sequence":"first","affiliation":[{"name":"Department of Surgery, Sunderby Hospital , Lule\u00e5 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Wennstig","sequence":"additional","affiliation":[{"name":"Department of Surgery and Perioperative sciences\/Surgery, Ume\u00e5 University , Ume\u00e5 , Sweden"},{"name":"Department of Oncology, Sundsvall Hospital , Sundsvall , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Garmo","sequence":"additional","affiliation":[{"name":"Regional Cancer Center, Uppsala University , Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Regional Cancer Center, Uppsala University , Uppsala , Sweden"},{"name":"Translational Oncology & Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King\u2019s College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greger","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, Uppsala University, University Hospital , Uppsala , Sweden"},{"name":"Department of Oncology, G\u00e4vle Hospital , G\u00e4vle , Sweden"},{"name":"Department of Oncology, Visby Hospital , Visby , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Blomqvist","sequence":"additional","affiliation":[{"name":"Department of Oncology, Helsinki University Hospital , Helsinki , Finland"},{"name":"Department of Oncology, \u00d6rebro University Hospital , \u00d6rebro , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute , Stockholm , Sweden"},{"name":"Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Wickberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-7296","authenticated-orcid":false,"given":"Fredrik","family":"W\u00e4rnberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-9543","authenticated-orcid":false,"given":"Malin","family":"Sund","sequence":"additional","affiliation":[{"name":"Department of Surgery and Perioperative sciences\/Surgery, Ume\u00e5 University , Ume\u00e5 , Sweden"},{"name":"Department of Surgery, University of Helsinki and Helsinki University Hospital , Helsinki , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-7265","authenticated-orcid":false,"given":"Charlotta","family":"Wadsten","sequence":"additional","affiliation":[{"name":"Department of Surgery and Perioperative sciences\/Surgery, Ume\u00e5 University , Ume\u00e5 , Sweden"},{"name":"Department of Surgery, Sundsvall Hospital , Sundsvall , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"2023111108340045500_znad290-B1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W","article-title":"Lymphangiosarcoma in postmastectomy lymphedema. 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