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Patients with intermittent claudication attending vascular surgery outpatient clinics were randomized (1:1) to receive either neuromuscular electrical stimulation (NMES) or not in addition to local standard care available at study centres (best medical therapy alone or plus supervised exercise therapy (SET)). The objective of this trial was to investigate the clinical efficacy of an NMES device in addition to local standard care in improving walking distances in patients with claudication. The primary outcome was change in absolute walking distance, measured by a standardized treadmill test at 3 months. Secondary outcomes included intermittent claudication (IC) distance, adherence, quality of life, and haemodynamic changes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 200 participants randomized, 160 were included in the primary analysis (intention to treat, Tobit regression model). The square root of absolute walking distance was analysed (due to a right-skewed distribution) and, although adjunctive NMES improved it at 3 months, no statistically significant effect was observed. SET as local standard care seemed to improve distance compared to best medical therapy at 3 months (3.29 units; 95 per cent c.i., 1.77 to 4.82; P &amp;lt; 0.001). Adjunctive NMES improved distance in mild claudication (2.88 units; 95 per cent c.i., 0.51 to 5.25; P = 0.02) compared to local standard care at 3 months. No serious adverse events relating to the device were reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Supervised exercise therapy is effective and NMES may provide further benefit in mild IC.<\/jats:p>\n                  <jats:p>This trial was supported by a grant from the Efficacy and Mechanism Evaluation Program, a Medical Research Council and National Institute for Health and Care Research partnership. Trial registration: ISRCTN18242823.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znad299","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T01:07:03Z","timestamp":1695690423000},"page":"1785-1792","source":"Crossref","is-referenced-by-count":5,"title":["Neuromuscular Electrical Stimulation for Intermittent Claudication (NESIC): multicentre, randomized controlled trial"],"prefix":"10.1093","volume":"110","author":[{"given":"Laura","family":"Burgess","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London , London , UK"},{"name":"Imperial Vascular Unit, Imperial College Healthcare NHS Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-1752","authenticated-orcid":false,"given":"Adarsh","family":"Babber","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London , London , 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