{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:53Z","timestamp":1791229493185,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Dutch Digestive Disease Foundation","award":["D17-25"],"award-info":[{"award-number":["D17-25"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cholecystectomy in patients with idiopathic acute pancreatitis (IAP) is controversial. A randomized trial found cholecystectomy to reduce the recurrence rate of IAP but did not include preoperative endoscopic ultrasonography (EUS). As EUS is effective in detecting gallstone disease, cholecystectomy may be indicated only in patients with gallstone disease. This study aimed to determine the diagnostic value of EUS in patients with IAP, and the rate of recurrent pancreatitis in patients in whom EUS could not determine the aetiology (EUS-negative IAP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This prospective multicentre cohort study included patients with a first episode of IAP who underwent outpatient EUS. The primary outcome was detection of aetiology by EUS. Secondary outcomes included adverse events after EUS, recurrence of pancreatitis, and quality of life during 1-year follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After screening 957 consecutive patients with acute pancreatitis from 24 centres, 105 patients with IAP were included and underwent EUS. In 34 patients (32 per cent), EUS detected an aetiology: (micro)lithiasis and biliary sludge (23.8 per cent), chronic pancreatitis (6.7 per cent), and neoplasms (2.9 per cent); 2 of the latter patients underwent pancreatoduodenectomy. During 1-year follow-up, the pancreatitis recurrence rate was 17 per cent (12 of 71) among patients with EUS-negative IAP versus 6 per cent (2 of 34) among those with positive EUS. Recurrent pancreatitis was associated with poorer quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>EUS detected an aetiology in a one-third of patients with a first episode of IAP, requiring mostly cholecystectomy or pancreatoduodenectomy. The role of cholecystectomy in patients with EUS-negative IAP remains uncertain and warrants further study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znad318","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:46:51Z","timestamp":1696859211000},"page":"1877-1882","source":"Crossref","is-referenced-by-count":19,"title":["Prospective multicentre study of indications for surgery in patients with idiopathic acute pancreatitis following endoscopic ultrasonography (PICUS)"],"prefix":"10.1093","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-8389","authenticated-orcid":false,"given":"Devica S","family":"Umans","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, location University of Amsterdam , Amsterdam , the Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism , Amsterdam UMC, Amsterdam , The Netherlands"},{"name":"Department of Research and Development, St Antonius Hospital , Nieuwegein , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester C","family":"Timmerhuis","sequence":"additional","affiliation":[{"name":"Department of Research and Development, St Antonius Hospital , Nieuwegein , the Netherlands"},{"name":"Department of Surgery, St Antonius Hospital , Nieuwegein , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Paule G F","family":"Anten","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Franciscus Gasthuis and Vlietland , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Haga Hospital , The Hague , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina A","family":"Bijlsma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Martini Hospital , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Boxhoorn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, location University of Amsterdam , Amsterdam , the Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism , Amsterdam UMC, Amsterdam , The Netherlands"},{"name":"Department of Research and Development, St Antonius Hospital , Nieuwegein , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno A","family":"Brink","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Meander Medical Centre , Amersfoort , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter L","family":"Curvers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Catharina Hospital , Eindhoven , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brechje C","family":"van Eijck","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Spaarne Gasthuis , Haarlem , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Willemien","family":"Erkelens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Gelre Hospital , Apeldoorn , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin J M","family":"van Geenen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Radboud University Medical Centre , Nijmegen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter L","family":"Hazen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Elisabeth-Tweesteden Hospital , Tilburg , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal V","family":"Hoge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Maastricht University Medical Centre , Maastricht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke","family":"Hol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Maasstad Hospital , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin","family":"Inderson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Centre , Leiden , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth M","family":"Kager","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Noordwest Ziekenhuisgroep , Alkmaar , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd D","family":"Kuiken","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, OLVG , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E","family":"Perk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medical Centre Haaglanden , The Hague , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger","family":"Quispel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Reinier de Graaf Gasthuis , Delft , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa E H","family":"R\u00f6mkens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital , Den Bosch , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J","family":"Sperna Weiland","sequence":"additional","affiliation":[{"name":"Department of Research and Development, St Antonius Hospital , Nieuwegein , the Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Radboud University Medical Centre , Nijmegen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke Y","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Albert Schweitzer Hospital , Dordrecht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels G","family":"Venneman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medisch Spectrum Twente , Enschede , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St Antonius Hospital , Nieuwegein , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy L J","family":"van Wanrooij","sequence":"additional","affiliation":[{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism , Amsterdam UMC, Amsterdam , The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, location Vrije Universiteit , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J","family":"Witteman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Hospital Gelderse Vallei , Ede , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-9350","authenticated-orcid":false,"given":"Marc G","family":"Besselink","sequence":"additional","affiliation":[{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism , Amsterdam UMC, Amsterdam , The Netherlands"},{"name":"Department of Surgery, Amsterdam UMC, location University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanin E","family":"van Hooft","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Centre , Leiden , the 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