{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:37:10Z","timestamp":1792291030321,"version":"4.4.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The rate of incisional hernia after closure of a temporary loop ileostomy is significant. Synthetic meshes are still commonly avoided in contaminated wounds. The Preloop trial was a multicentre RCT designed to evaluate the benefits of synthetic mesh in incisional hernia prevention, and its safety for use in a contaminated surgical site compared with biological mesh.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Study patients who underwent closure of a loop ileostomy after anterior resection for rectal cancer were assigned to receive either retrorectus synthetic or biological mesh to prevent incisional hernia. The primary outcomes were surgical-site infections within 30 days, and clinical or radiological incisional hernia incidence at 10 months. Secondary outcomes were reoperation rate, operating time, duration of hospital stay, other complications within 30 days of surgery, 5-year quality of life measured by RAND-36, and incisional hernia incidence within 5 years of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between November 2018 and September 2021, 102 patients were randomised, of whom 97 received the intended allocation. At 10-month follow-up, 90 patients had undergone clinical evaluation and 88 radiological evaluation. One patient in each group (2 per cent) had a clinical diagnosis of incisional hernia (P = 0.950) and one further patient in each group had a CT-confirmed incisional hernia (P = 0.949). The number of other complications, reoperation rate, operating time, and duration of hospital stay did not differ between the study groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Synthetic mesh appeared comparable to biological mesh in efficacy and safety for incisional hernia prevention at the time of loop ileostomy closure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration number<\/jats:title>\n                  <jats:p>NCT03445936 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znad362","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T20:33:22Z","timestamp":1699562002000},"source":"Crossref","is-referenced-by-count":9,"title":["Prevention of incisional hernia with retrorectus synthetic mesh <i>versus<\/i> biological mesh following loop ileostomy closure (Preloop trial)"],"prefix":"10.1093","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-2514","authenticated-orcid":false,"given":"Elisa J","family":"M\u00e4k\u00e4r\u00e4inen","sequence":"first","affiliation":[{"name":"Department of Surgery, Medical Research Centre Oulu, Oulu University Hospital , Oulu , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki T","family":"Wiik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Research Centre Oulu, Oulu University Hospital , Oulu , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyrki A O","family":"K\u00f6ssi","sequence":"additional","affiliation":[{"name":"Department of Surgery, P\u00e4ij\u00e4t-H\u00e4me Central Hospital , Lahti , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja M","family":"Pinta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sein\u00e4joki Central Hospital , Sein\u00e4joki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena-Mari J","family":"M\u00e4ntym\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tampere University Hospital , Tampere , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K","family":"Mattila","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jyv\u00e4skyl\u00e4 Central Hospital , Jyv\u00e4skyl\u00e4 , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko J","family":"Nikki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Research Centre Oulu, Oulu University Hospital , Oulu , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyri E","family":"J\u00e4rvinen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Research Centre Oulu, Oulu University Hospital , Oulu , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi P","family":"Ohtonen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Research Centre Oulu, Oulu University Hospital , Oulu , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero T","family":"Rautio","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Research Centre Oulu, Oulu University Hospital , Oulu , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"2024010615305648200_znad362-B1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s00268-013-2109-3","article-title":"Prophylactic mesh reinforcement reduces stomal site incisional hernia after ileostomy closure","volume":"37","author":"Liu","year":"2013","journal-title":"World J Surg"},{"key":"2024010615305648200_znad362-B2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(19)32637-6","article-title":"Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial","volume":"395","author":"Reinforcement of Closure of Stoma Site (ROCSS) Collaborative and West Midlands Research Collaborative","year":"2020","journal-title":"Lancet"},{"key":"2024010615305648200_znad362-B3","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/ans.17359","article-title":"Incisional hernia following ileostomy closure: who's at risk? The Gold Coast experience","volume":"92","author":"Bloomfield","year":"2022","journal-title":"ANZ J Surg"},{"key":"2024010615305648200_znad362-B4","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s10029-021-02405-9","article-title":"The incisional hernia epidemic: evaluation of outcomes, recurrence, and expenses using the healthcare cost and utilization project (HCUP) datasets","volume":"25","author":"Rhemtulla","year":"2021","journal-title":"Hernia"},{"key":"2024010615305648200_znad362-B5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10029-019-01961-5","article-title":"Systematic review and meta-analysis of incisional hernia post-reversal of ileostomy","volume":"24","author":"De Haes","year":"2020","journal-title":"Hernia"},{"key":"2024010615305648200_znad362-B6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jamcollsurg.2019.12.008","article-title":"Safety and efficacy of synthetic mesh for ventral hernia repair in a contaminated field","volume":"230","author":"Warren","year":"2020","journal-title":"J Am Coll Surg"},{"key":"2024010615305648200_znad362-B7","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/SLA.0000000000004336","article-title":"Preventing recurrence in clean and contaminated hernias using biologic versus synthetic mesh in ventral hernia repair: the PRICE randomized clinical trial","volume":"273","author":"Harris","year":"2021","journal-title":"Ann Surg"},{"key":"2024010615305648200_znad362-B8","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s10029-022-02681-z","article-title":"Retrorectus mesh reinforcement of ileostomy site fascial closure: stoma closure and reinforcement (SCAR) trial phase I\/II results","volume":"26","author":"Shaw","year":"2022","journal-title":"Hernia"},{"key":"2024010615305648200_znad362-B9","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.surg.2015.07.004","article-title":"Bioprosthetic mesh reinforcement during temporary stoma closure decreases the rate of incisional hernia: a blinded, case-matched study in 94 patients with rectal cancer","volume":"158","author":"Maggiori","year":"2015","journal-title":"Surgery"},{"key":"2024010615305648200_znad362-B10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1186\/s13063-018-2977-9","article-title":"Preloop trial: study protocol for a randomized controlled trial","volume":"19","author":"M\u00e4k\u00e4r\u00e4inen-Uhlb\u00e4ck","year":"2018","journal-title":"Trials"},{"key":"2024010615305648200_znad362-B11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12893-023-01961-4","article-title":"Synthetic mesh versus biological mesh to prevent incisional hernia after loop-ileostomy closure: a randomized feasibility trial","volume":"27","author":"M\u00e4k\u00e4r\u00e4inen","year":"2023","journal-title":"BMC Surg"},{"key":"2024010615305648200_znad362-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10029-014-1342-5","article-title":"European Hernia society guidelines on the closure of abdominal wall incisions","volume":"19","author":"Muysoms","year":"2015","journal-title":"Hernia"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/1\/znad362\/55121805\/znad362.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/1\/znad362\/55121805\/znad362.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T15:31:10Z","timestamp":1704555070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/doi\/10.1093\/bjs\/znad362\/7379645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,11,7]]},"published-print":{"date-parts":[[2024,1,3]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znad362","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,11,7]]},"article-number":"znad362"}}