{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:55:09Z","timestamp":1784865309606,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR20\/00008"],"award-info":[{"award-number":["JR20\/00008"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Histopathological and molecular features have been proposed to hold prognostic information, but few have been validated. The aim of this retrospective study was to validate the Genetic And Morphological Evaluation (\u2018GAME\u2019) score and assess the impact of histological characteristics on the prognosis in patients with colorectal liver metastases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were collected from 176 patients with metastatic colorectal cancer undergoing liver resection at Hospital de la Santa Creu i Sant Pau. Patients were classified into Genetic And Morphological Evaluation score groups and relapse-free survival and overall survival were calculated. Histopathological changes in colorectal liver metastases were documented and prognostic variables were selected to create a post-surgery score, called the Histopathological, Clinical, And Molecular (\u2018HICAM\u2019) score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Regarding the Genetic And Morphological Evaluation score, the high-risk group had a median relapse-free survival of 8.8 months, compared with 20.5 months for the low-risk group (P = 0.005), and the high-risk group had a median overall survival of 37.8 months, compared with 67.0 months for the low-risk group (P = 0.005). Histological examination of 144 liver samples showed that the desertic immune phenotype was associated with worse overall survival in the multivariable analysis (P = 0.020). The Histopathological, Clinical, And Molecular score variables were age at diagnosis, tumour burden score, carcinoembryonic antigen levels greater than or equal to 20\u2005ng\/ml, primary tumour resection, TNM stage at diagnosis, molecular status, histopathological growth patterns, and immune phenotypes of the liver. The high-risk group had a median relapse-free survival of 8.4 months, compared with 20.4 months for the low-risk group (P &amp;lt; 0.001), and a median overall survival of 30.4 months, compared with 105.0 months for the low-risk group (P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The Genetic And Morphological Evaluation score was validated as a preoperative prognostic tool to predict candidacy for liver resection. The Histopathological, Clinical, And Molecular score could be useful to assess adjuvant treatment after hepatic resection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znae016","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T13:02:52Z","timestamp":1710507772000},"source":"Crossref","is-referenced-by-count":11,"title":["Histopathological, Clinical, And Molecular (HICAM) score for patients with colorectal liver metastases"],"prefix":"10.1093","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-3570","authenticated-orcid":false,"given":"Berta","family":"Mart\u00edn-Cullell","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"},{"name":"Translational Medical Oncology Laboratory, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) , Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f3noma de Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C","family":"Virgili","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"},{"name":"Translational Medical Oncology Laboratory, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) , Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f3noma de Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-3927","authenticated-orcid":false,"given":"Pau","family":"Riera","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"},{"name":"U705, Instituto de Salud Carlos III, Center for Biomedical Research on Rare Diseases (CIBERER) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Mirallas","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Vall d\u2019Hebron Hospital Campus and Vall d\u2019Hebron Institute of Oncology (VHIO) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"Pelegr\u00edn","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"},{"name":"Translational Medical Oncology Laboratory, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"S\u00e1nchez-Cab\u00fas","sequence":"additional","affiliation":[{"name":"Surgery Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Molina","sequence":"additional","affiliation":[{"name":"Surgery Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Szafranska","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-6588","authenticated-orcid":false,"given":"David","family":"P\u00e1ez","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain"},{"name":"Translational Medical Oncology Laboratory, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) , Barcelona , Spain"},{"name":"U705, Instituto de Salud Carlos III, Center for Biomedical Research on Rare Diseases (CIBERER) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,15]]},"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/3\/znae016\/57117913\/znae016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/3\/znae016\/57117913\/znae016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T09:47:09Z","timestamp":1711705629000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/doi\/10.1093\/bjs\/znae016\/7629855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,15]]},"published-print":{"date-parts":[[2024,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znae016","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,3]]},"article-number":"znae016"}}