{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:16:51Z","timestamp":1775819811647,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Electrosurgical devices are commonly used during mastectomy for simultaneous dissection and haemostasis, and can provide potential benefits regarding vessel and lymphatic ligation. The aim of this prospective RCT was to assess whether using a vessel-sealing device (LigaSure\u2122) improves perioperative outcomes compared with monopolar diathermy when performing simple mastectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients were recruited prospectively and randomized in a 1 : 1 manner to undergo simple mastectomy using either LigaSure\u2122 or conventional monopolar diathermy at a single centre. The primary outcome was the number of days the drain remained in situ after surgery. Secondary outcomes of interest included operating time and complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 86 patients were recruited (42 were randomized to the monopolar diathermy group and 44 were randomized to the LigaSure\u2122 group). There was no significant difference in the mean number of days the drain remained in situ between the monopolar diathermy group and the LigaSure\u2122 group (7.75 days versus 8.23 days; P = 0.613) and there was no significant difference in the mean total drain output between the monopolar diathermy group and the LigaSure\u2122 group (523.50\u2005ml versus 572.80\u2005ml; P = 0.694). In addition, there was no significant difference in the mean operating time between the groups, for simple mastectomy alone (88.25\u2005min for the monopolar diathermy group versus 107.20\u2005min for the LigaSure\u2122 group; P = 0.078) and simple mastectomy with sentinel lymph node biopsy (107.20\u2005min for the monopolar diathermy group versus 114.40\u2005min for the LigaSure\u2122 group; P = 0.440).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this double-blinded single-centre RCT, there was no difference in the total drain output or the number of days the drain remained in situ between the monopolar diathermy group and the LigaSure\u2122 group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration number<\/jats:title>\n                  <jats:p>EudraCT 2018-003191-13 BEAUMONT HOSPITAL REC 18\/66.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znae029","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T14:58:23Z","timestamp":1710773903000},"source":"Crossref","is-referenced-by-count":5,"title":["Monopolar diathermy <i>versus<\/i> a vessel-sealing device for reducing postoperative drain output after simple mastectomy: randomized clinical trial"],"prefix":"10.1093","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-5128","authenticated-orcid":false,"given":"Stephen","family":"Keelan","sequence":"first","affiliation":[{"name":"Department of Surgery, RCSI University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Beaumont RCSI Cancer Centre, Beaumont Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-2022","authenticated-orcid":false,"given":"Gavin P","family":"Dowling","sequence":"additional","affiliation":[{"name":"Department of Surgery, RCSI 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Beaumont Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amenah A","family":"Dhannoon","sequence":"additional","affiliation":[{"name":"Beaumont RCSI Cancer Centre, Beaumont Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorcha","family":"O\u2019Grady","sequence":"additional","affiliation":[{"name":"Department of Surgery, RCSI University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Beaumont RCSI Cancer Centre, Beaumont Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eithne","family":"Downey","sequence":"additional","affiliation":[{"name":"Beaumont RCSI Cancer Centre, Beaumont Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-633X","authenticated-orcid":false,"given":"Jarlath","family":"Bolger","sequence":"additional","affiliation":[{"name":"Beaumont RCSI 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