{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:26Z","timestamp":1787008526618,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hospital of Southern Jutland","award":["62786-2020"],"award-info":[{"award-number":["62786-2020"]}]},{"DOI":"10.13039\/501100024075","name":"Region of Southern Denmark","doi-asserted-by":"publisher","award":["20\/14818"],"award-info":[{"award-number":["20\/14818"]}],"id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021817","name":"Knud og Edith Eriksens Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Evidence for the routine use of robotic technology and its impact on short-term outcomes in colon cancer surgery is lacking. The aim of this study was to compare the surgically induced systemic stress response and clinical and patient-reported outcomes for patients undergoing robot-assisted or laparoscopic colon cancer surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this double-blinded superiority RCT completed between August 2021 and March 2023, patients with stage 1\u20133 colon cancer were randomized in a 1 : 1 ratio to undergo either robot-assisted or laparoscopic colon cancer surgery. The primary outcome was changes in the systemic stress response, characterized by C-reactive protein expression in the first three postoperative days. Secondary outcomes were intraoperative and postoperative complications and patient-reported outcomes. The latter included quality of recovery-15 and pain intensity using a visual analogue scale.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In total, 128 patients were screened for potential inclusion in this study; 50 patients (25 in the robot-assisted group and 25 in the laparoscopic group) were included in the final follow-up and analysis. The postoperative C-reactive protein response was higher on the first postoperative day in the laparoscopic group (mean difference = 19.88\u2005mg\/l, 95% c.i. 3.89\u201335.86; P = 0.045). No statistically significant differences were noted for C-reactive protein expression on the second and third postoperative days.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Adopting robot-assisted surgery for stage 1\u20133 colon cancer is associated with a reduction in the surgical stress response.<\/jats:p>\n <\/jats:sec>\n \n Registration number<\/jats:title>\n NCT04687384 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bjs\/znae049","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T08:33:48Z","timestamp":1708245228000},"source":"Crossref","is-referenced-by-count":35,"title":["Surgical stress response in robot-assisted\n versus<\/i>\n laparoscopic surgery for colon cancer (SIRIRALS): randomized clinical trial"],"prefix":"10.1093","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-604X","authenticated-orcid":false,"given":"Pedja","family":"Cuk","sequence":"first","affiliation":[{"name":"Department of General and Colorectal Surgery, University Hospital of Southern Jutland , Aabenraa , Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark , Odense , Denmark"},{"name":"Open Patient Data Explorative Network, Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindaugas","family":"Tiskus","sequence":"additional","affiliation":[{"name":"Department of General and Colorectal Surgery, University Hospital of Southern Jutland , Aabenraa , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Open Patient Data Explorative Network, Odense University Hospital , Odense , Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate Lykke","family":"Lambertsen","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark , Odense , Denmark"},{"name":"Department of Neurology, Odense University Hospital , Odense , Denmark"},{"name":"Department of Clinical Research, BRIDGE, Brain Research\u2014Inter-Disciplinary Guided Excellence, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Backer Mogensen","sequence":"additional","affiliation":[{"name":"Institute of Regional Health Research, University of Southern Denmark , Odense , Denmark"},{"name":"Department of Emergency Medicine, Hospital Soenderjylland, University Hospital of Southern Denmark , Aabenraa , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Festersen Nielsen","sequence":"additional","affiliation":[{"name":"Department of General and Colorectal Surgery, University Hospital of Southern Jutland , Aabenraa , Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Helligs\u00f8","sequence":"additional","affiliation":[{"name":"Department of General and Colorectal Surgery, University Hospital of Southern Jutland , Aabenraa , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-268X","authenticated-orcid":false,"given":"Ismail","family":"G\u00f6genur","sequence":"additional","affiliation":[{"name":"Surgical Department, Centre for Surgical Science, Zealand University Hospital , Koege , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bremholm Elleb\u00e6k","sequence":"additional","affiliation":[{"name":"Open Patient Data Explorative Network, Odense University Hospital , Odense , Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark , Odense , Denmark"},{"name":"Research Unit of Surgery, Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,5]]},"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/3\/znae049\/57117808\/znae049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/3\/znae049\/57117808\/znae049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T05:46:35Z","timestamp":1711691195000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/doi\/10.1093\/bjs\/znae049\/7619345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,5]]},"published-print":{"date-parts":[[2024,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znae049","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,3]]},"article-number":"znae049"}}