{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:07:24Z","timestamp":1791360444093,"version":"4.3.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["2013-5920"],"award-info":[{"award-number":["2013-5920"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Trials have demonstrated the safety of omitting completion axillary lymph node dissection in patients with cT1\u20132 N0 breast cancer operated with breast-conserving surgery who have limited metastatic burden in the sentinel lymph node. The aim of this registry study was to provide insight into the oncological safety of omitting completion axillary treatment in patients operated with mastectomy who have limited-volume sentinel lymph node metastasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women diagnosed in 2013\u20132014 with unilateral cT1\u20132 N0 breast cancer treated with mastectomy, with one to three sentinel lymph node metastases (pN1mi\u2013pN1a), were identified from the Netherlands Cancer Registry, and classified by axillary treatment: no completion axillary treatment, completion axillary lymph node dissection, regional radiotherapy, or completion axillary lymph node dissection followed by regional radiotherapy. The primary endpoint was 5-year regional recurrence rate. Secondary endpoints included recurrence-free interval and overall survival, among others.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 1090 patients were included (no completion axillary treatment, 219 (20.1%); completion axillary lymph node dissection, 437 (40.1%); regional radiotherapy, 327 (30.0%); completion axillary lymph node dissection and regional radiotherapy, 107 (9.8%)). Patients in the group without completion axillary treatment had more favourable tumour characteristics and were older. The overall 5-year regional recurrence rate was 1.3%, and did not differ significantly between the groups. The recurrence-free interval was also comparable among groups. The group of patients who did not undergo completion axillary treatment had statistically significantly worse 5-year overall survival, owing to a higher percentage of non-cancer deaths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this registry study of patients with cT1\u20132 N0 breast cancer treated with mastectomy, with low-volume sentinel lymph node metastasis, the 5-year regional recurrence rate was low and comparable between patients with and without completion axillary treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znae077","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T08:49:59Z","timestamp":1712738999000},"source":"Crossref","is-referenced-by-count":17,"title":["De-escalation of axillary treatment in the event of a positive sentinel lymph node biopsy in cT1\u20132 N0 breast cancer treated with mastectomy: nationwide registry study (BOOG 2013-07)"],"prefix":"10.1093","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-2308","authenticated-orcid":false,"given":"Sabine R","family":"de Wild","sequence":"first","affiliation":[{"name":"Maastricht University Medical Centre+, Department of Surgery, GROW School for Oncology and Reproduction , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori M","family":"van Roozendaal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Zuyderland Medical Centre , Heerlen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6773-9668","authenticated-orcid":false,"given":"Johannes H W","family":"de Wilt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Medical Centre , Nijmegen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thijs","family":"van Dalen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos A","family":"van der Hage","sequence":"additional","affiliation":[{"name":"Department of Surgery, Leiden University Medical Centre , Leiden , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederieke H","family":"van Duijnhoven","sequence":"additional","affiliation":[{"name":"Department of Surgery, Netherlands Cancer Institute\u2014Antoni van Leeuwenhoek Hospital , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine M","family":"Simons","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre+, Department of Surgery, GROW School for Oncology and Reproduction , Maastricht , The Netherlands"},{"name":"Department of Radiotherapy, Erasmus Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert-Jan","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-509X","authenticated-orcid":false,"given":"Linda","family":"de Munck","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL) , Utrecht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-729X","authenticated-orcid":false,"given":"Sander M J","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ , Maastricht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth J","family":"Boersma","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre+, Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction , Maastricht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine C","family":"Linn","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Netherlands Cancer Institute\u2014Antoni van Leeuwenhoek Hospital , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc B I","family":"Lobbes","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Zuyderland Medical Centre , Sittard-Geleen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M P","family":"Poortmans","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Iridium Netwerk , Antwerp , Belgium"},{"name":"Faculty of Medicine and Health Sciences, University of Antwerp , Antwerp , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne C G","family":"Tjan-Heijnen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Maastricht University Medical Centre+ , Maastricht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen K B T","family":"van de Vijver","sequence":"additional","affiliation":[{"name":"Department of Pathology, Netherlands Cancer Institute\u2014Antoni van Leeuwenhoek , Amsterdam , the Netherlands"},{"name":"Department of Pathology, University Hospital Ghent\u2014Cancer Research Institute Ghent , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health, Tilburg University , Tilburg , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Helen","family":"Westenberg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Radiotherapiegroep Arnhem , Arnhem , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J A","family":"Strobbe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Canisius Wilhelmina Hospital , Nijmegen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein L","family":"Smidt","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre+, Department of Surgery, GROW School for Oncology and Reproduction , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,10]]},"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/4\/znae077\/57350957\/znae077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/4\/znae077\/57350957\/znae077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T12:15:58Z","timestamp":1714392958000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/doi\/10.1093\/bjs\/znae077\/7643106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,10]]},"published-print":{"date-parts":[[2024,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znae077","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,4]]},"article-number":"znae077"}}