{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:37:19Z","timestamp":1775522239484,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Barrett's oesophagus surveillance places significant burden on endoscopy services yet is vital to detect early cancerous change. Oesophageal cell collection device (OCCD) testing was introduced across Scotland for Barrett's surveillance in response to the COVID-19 pandemic. This national pragmatic retrospective study presents the CytoSCOT programme results and evaluates whether OCCD testing is successfully identifying high-risk Barrett's patients requiring urgent endoscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients undergoing OCCD testing for Barrett's surveillance across 11 Scottish health boards over a 32-month period were identified. Patients who underwent endoscopy within 12 months of OCCD test were included. Individual patient records were interrogated to record clinical information and OCCD test result to categorize patients into risk groups. Endoscopic histopathology results were analysed according to risk group and segment length. Patients were deemed high risk if the OCCD test demonstrated atypia and\/or p53 positivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>4204 OCCD tests were performed in 3745 patients: 608 patients underwent endoscopy within 12 months and were included in this analysis. Patients with longer Barrett's segments were significantly more likely to have an abnormal OCCD test. 50\/608 patients (8.2%) had high-grade dysplasia or cancer on endoscopic biopsies: this equates to 1.3% of the total group (50\/3745). 46\/50 patients (92.0%) were deemed high risk, triggering urgent endoscopy: this rose to 100% with insufficient tests removed. There were no cancers diagnosed within 12 months post-OCCD in the low-risk group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>OCCD testing is an effective triage tool to identify high-risk patients with Barrett's oesophagus requiring further investigation with endoscopy within the real-world setting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znae117","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:06:50Z","timestamp":1715569610000},"source":"Crossref","is-referenced-by-count":6,"title":["Oesophageal cell collection device and biomarker testing to identify high-risk Barrett's patients requiring endoscopic investigation"],"prefix":"10.1093","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-193X","authenticated-orcid":false,"given":"Siobhan","family":"Chien","sequence":"first","affiliation":[{"name":"School of Cancer Sciences, University of Glasgow , Glasgow , UK"},{"name":"Centre for Sustainable Delivery, Golden Jubilee National Hospital , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Glen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Queen Elizabeth University Hospital , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Penman","sequence":"additional","affiliation":[{"name":"Centre for Liver & Digestive Disorders, Royal Infirmary of Edinburgh , Edinburgh , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Cruickshank","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Victoria Hospital , Kirkcaldy , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Bryce","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital Wishaw , Wishaw , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Crumley","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Forth Valley Royal Hospital , Larbert , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perminder","family":"Phull","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Aberdeen Royal Infirmary , Aberdeen , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ninewells Hospital , Dundee , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Borders General Hospital , Melrose , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Gunjaca","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Raigmore Hospital , Inverness , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeyakumar","family":"Apollos","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dumfries & Galloway Royal Infirmary , Dumfries , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital Crosshouse , Kilmarnock , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Fullarton","sequence":"additional","affiliation":[{"name":"Centre for Sustainable Delivery, Golden Jubilee National Hospital , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2024053111464401100_znae117-B1","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.3748\/wjg.v21.i26.7933","article-title":"Esophageal cancer: risk factors, screening and endoscopic treatment in Western and Eastern countries","volume":"21","author":"Domper Arnal","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2024053111464401100_znae117-B2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gutjnl-2013-305372","article-title":"British Society of Gastroenterology guidelines on the diagnosis and management of Barrett\u2019s oesophagus","volume":"63","author":"Fitzgerald","year":"2014","journal-title":"Gut"},{"key":"2024053111464401100_znae117-B3","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/gutjnl-2011-300730","article-title":"The incidence of oesophageal adenocarcinoma in non-dysplastic Barrett\u2019s oesophagus: a meta-analysis","volume":"61","author":"Desai","year":"2012","journal-title":"Gut"},{"key":"2024053111464401100_znae117-B4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.gastro.2011.04.061","article-title":"Durability of radiofrequency ablation in Barrett\u2019s esophagus with dysplasia","volume":"141","author":"Shaheen","year":"2011","journal-title":"Gastroenterology"},{"key":"2024053111464401100_znae117-B5","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1136\/gutjnl-2014-308865","article-title":"Surveillance endoscopy is associated with improved outcomes of oesophageal adenocarcinoma detected in patients with Barrett\u2019s oesophagus","volume":"65","author":"El-Serag","year":"2016","journal-title":"Gut"},{"key":"2024053111464401100_znae117-B6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2015.11.040","article-title":"Magnitude of missed esophageal adenocarcinoma after Barrett\u2019s esophagus diagnosis: a systematic review and meta-analysis","volume":"150","author":"Visrodia","year":"2016","journal-title":"Gastroenterology"},{"key":"2024053111464401100_znae117-B7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/2050640617737466","article-title":"\u2018Missed\u2019 oesophageal adenocarcinoma and high-grade dysplasia in Barrett\u2019s oesophagus patients: a large population-based study","volume":"6","author":"van Putten","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"2024053111464401100_znae117-B8","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1053\/j.gastro.2023.05.044","article-title":"Magnitude and time-trends of post-endoscopy esophageal adenocarcinoma and post-endoscopy esophageal neoplasia in a population-based cohort study: the Nordic Barrett\u2019s esophagus study","volume":"165","author":"Wani","year":"2023","journal-title":"Gastroenterology"},{"key":"2024053111464401100_znae117-B9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/flgastro-2020-101492","article-title":"Gastrointestinal endoscopy during COVID-19: when less is more","volume":"11","author":"Edwards","year":"2020","journal-title":"Frontline Gastroenterol"},{"key":"2024053111464401100_znae117-B10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0140-6736(20)31099-0","article-title":"Cytosponge-trefoil factor 3 versus usual care to identify Barrett\u2019s oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial","volume":"396","author":"Fitzgerald","year":"2020","journal-title":"Lancet"},{"key":"2024053111464401100_znae117-B11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1470-2045(21)00667-7","article-title":"Use of a cytosponge biomarker panel to prioritise endoscopic Barrett\u2019s oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot","volume":"23","author":"Pilonis","year":"2022","journal-title":"Lancet Oncol"},{"key":"2024053111464401100_znae117-B12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S2468-1253(16)30118-2","article-title":"Risk stratification of Barrett\u2019s oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study","volume":"2","author":"Ross-Innes","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2024053111464401100_znae117-B13","doi-asserted-by":"crossref","first-page":"e1001780","DOI":"10.1371\/journal.pmed.1001780","article-title":"Evaluation of a minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett\u2019s esophagus: a multi-center case\u2013control study","volume":"12","author":"Ross-Innes","year":"2015","journal-title":"PLoS Med"},{"key":"2024053111464401100_znae117-B14","doi-asserted-by":"crossref","first-page":"e054258","DOI":"10.1136\/bmjopen-2021-054258","article-title":"Patient-reported experiences and views on the Cytosponge test: a mixed-methods analysis from the BEST3 trial","volume":"12","author":"Maroni","year":"2022","journal-title":"BMJ Open"},{"key":"2024053111464401100_znae117-B15","volume-title":"Endoscopy and Urology Diagnostic: Recovery and Renewal Plan","author":"Scottish Government","year":"2021"},{"key":"2024053111464401100_znae117-B16","doi-asserted-by":"crossref","DOI":"10.1093\/dote\/doae002","article-title":"National adoption of an esophageal cell collection device for Barrett\u2019s esophagus surveillance: impact on delay to investigation and pathological findings","volume":"37","author":"Chien","year":"2024","journal-title":"Dis Esophagus"},{"key":"2024053111464401100_znae117-B17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/qjmed\/hcad093","article-title":"Real-world implementation of non-endoscopic triage testing for Barrett\u2019s oesophagus during COVID-19","volume":"116","author":"Landy","year":"2023","journal-title":"QJM"},{"key":"2024053111464401100_znae117-B18","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cgh.2018.08.033","article-title":"Incidence of progression of persistent nondysplastic Barrett\u2019s esophagus to malignancy","volume":"17","author":"Peters","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2024053111464401100_znae117-B19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1136\/gut.2009.176701","article-title":"Risk of malignant progression in patients with Barrett\u2019s oesophagus: a Dutch nationwide cohort study","volume":"59","author":"de Jonge","year":"2010","journal-title":"Gut"},{"key":"2024053111464401100_znae117-B20","volume-title":"Cytosponge for Detecting Abnormal Cells in the Oesophagus","author":"National Institute for Health and Care Excellence","year":"2020"},{"key":"2024053111464401100_znae117-B21","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.cgh.2013.05.007","article-title":"Association between length of Barrett\u2019s esophagus and risk of high-grade dysplasia or adenocarcinoma in patients without dysplasia","volume":"11","author":"Anaparthy","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2024053111464401100_znae117-B22","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.cgh.2021.02.005","article-title":"Characterization of prevalent, post-endoscopy, and incident esophageal cancer in the United States: a large retrospective cohort study","volume":"20","author":"Vajravelu","year":"2022","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/5\/znae117\/57639412\/znae117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/5\/znae117\/57639412\/znae117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T20:18:31Z","timestamp":1717186711000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/doi\/10.1093\/bjs\/znae117\/7670737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5,3]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znae117","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]},"article-number":"znae117"}}