{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:45:06Z","timestamp":1790131506337,"version":"4.0.1"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RCSI-Bon Secours Hospital Dublin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic inflammatory response markers have been found to have a prognostic role in several cancers, but their value in predicting the response to neoadjuvant chemotherapy in breast cancer is uncertain. A systematic review and meta-analysis of the literature was carried out to investigate this.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of electronic databases was conducted to identify studies that explored the predictive value of circulating systemic inflammatory response markers in patients with breast cancer before commencing neoadjuvant therapy. A meta-analysis was undertaken for each inflammatory marker where three or more studies reported pCR rates in relation to the inflammatory marker. Outcome data are reported as ORs and 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 49 studies were included, of which 42 were suitable for meta-analysis. A lower pretreatment neutrophil-to-lymphocyte ratio was associated with an increased pCR rate (pooled OR 1.66 (95% c.i. 1.32 to 2.09); P &amp;lt; 0.001). A lower white cell count (OR 1.96 (95% c.i. 1.29 to 2.97); P = 0.002) and a lower monocyte count (OR 3.20 (95% c.i. 1.71 to 5.97); P &amp;lt; 0.001) were also associated with a pCR. A higher lymphocyte count was associated with an increased pCR rate (OR 0.44 (95% c.i. 0.30 to 0.64); P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study found the pretreatment neutrophil-to-lymphocyte ratio, white cell count, lymphocyte count, and monocyte count of value in the prediction of a pCR in the neoadjuvant treatment of breast cancer. Further research is required to determine their value in specific breast cancer subtypes and to establish optimal cut-off values, before their adoption in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjs\/znae132","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:39:49Z","timestamp":1715243989000},"source":"Crossref","is-referenced-by-count":24,"title":["Predictive value of pretreatment circulating inflammatory response markers in the neoadjuvant treatment of breast cancer: meta-analysis"],"prefix":"10.1093","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-2022","authenticated-orcid":false,"given":"Gavin P","family":"Dowling","sequence":"first","affiliation":[{"name":"Department of Surgery, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Medical Oncology Lab, Department of Molecular Medicine, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Department of Surgery, Beaumont Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon R","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Department of Surgery, Beaumont Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Hegarty","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Department of Surgery, Beaumont Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5774-4500","authenticated-orcid":false,"given":"Sandra","family":"Hembrecht","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Department of Surgery, Beaumont Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Bracken","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead","family":"Toomey","sequence":"additional","affiliation":[{"name":"Medical Oncology Lab, Department of Molecular Medicine, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan T","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Medical Oncology Lab, Department of Molecular Medicine, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold D K","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences , Dublin , Ireland"},{"name":"Department of Surgery, Beaumont Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"2024052714330227600_znae132-B1","volume-title":"Pathological Complete Response in Neoadjuvant Treatment of High-Risk Early-Stage Breast Cancer: Use as an Endpoint to Support Accelerated 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