{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:54:29Z","timestamp":1789419269368,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Minimally invasive transcervical oesophagectomy is a surgical technique that offers radical oesophagectomy without the need for transthoracic access. The aim of this study was to evaluate the safety and feasibility of the minimally invasive transcervical oesophagectomy procedure and to report the refinement of this technique in a Western cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A single-centre prospective cohort study was designed as an IDEAL stage 2A study. Patients with oesophageal cancer (cT1b\u20134a N0\u20133 M0) who were scheduled for oesophagectomy with curative intent were eligible for inclusion in the study. The main outcome parameter was the postoperative pulmonary complication rate and the secondary outcomes were the anastomotic leakage, recurrent laryngeal nerve palsy, and R0 resection rates, as well as the lymph node yield.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 75 patients underwent minimally invasive transcervical oesophagectomy between January 2021 and November 2023. Several modifications to the surgical technique were registered, evaluated, and implemented in the context of IDEAL stage 2A. A total of 12 patients (16%) had postoperative pulmonary complications, including pneumonia (4 patients) and pleural effusion with drainage or aspiration (8 patients). Recurrent laryngeal nerve palsy was observed in 33 of 75 patients (44%), with recovery in 30 of 33 patients (91%). A total of 5 of 75 patients (7%) had anastomotic leakage. The median number of resected lymph nodes was 29 (interquartile range 22\u201337) and the R0 resection rate was 96% (72 patients).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Introducing minimally invasive transcervical oesophagectomy for oesophageal cancer in a Dutch institution is associated with a low rate of postoperative pulmonary complications and a high rate of temporary recurrent laryngeal nerve palsy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znae160","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T17:28:30Z","timestamp":1720632510000},"source":"Crossref","is-referenced-by-count":10,"title":["Minimally Invasive transCervical oEsophagectomy (MICE) for oesophageal cancer: prospective cohort study (IDEAL stage 2A)"],"prefix":"10.1093","volume":"111","author":[{"given":"Richard J M T","family":"Vercoulen","sequence":"first","affiliation":[{"name":"Department of Surgery, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linde","family":"van Veenendaal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene F","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlijn","family":"Hutteman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Shiozaki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoto Prefectural University of Medicine Hospital , Kyoto , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoto Prefectural University of Medicine Hospital , Kyoto , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-3987","authenticated-orcid":false,"given":"Camiel","family":"Rosman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-8557","authenticated-orcid":false,"given":"Bastiaan R","family":"Klarenbeek","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"2024073109230654500_znae160-B1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000497456","article-title":"Minimally invasive esophagectomy","volume":"37","author":"van der Sluis","year":"2020","journal-title":"Dig Surg"},{"key":"2024073109230654500_znae160-B2","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/SLA.0000000000005116","article-title":"Outcomes of esophagogastric cancer surgery during eight years of surgical auditing by the Dutch Upper Gastrointestinal Cancer Audit (DUCA)","volume":"274","author":"Voeten","year":"2021","journal-title":"Ann Surg"},{"key":"2024073109230654500_znae160-B3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0022-5223(19)41012-X","article-title":"Esophagectomy without thoracotomy","volume":"76","author":"Orringer","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024073109230654500_znae160-B4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bjs.9456","article-title":"Surgical resection strategy and the influence of radicality on outcomes in oesophageal cancer","volume":"101","author":"Davies","year":"2014","journal-title":"Br J Surg"},{"key":"2024073109230654500_znae160-B5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/bjs.10745","article-title":"Health-related quality of life after open transhiatal and transthoracic oesophagectomy for cancer","volume":"105","author":"Kauppila","year":"2018","journal-title":"Br J Surg"},{"key":"2024073109230654500_znae160-B6","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1097\/SLA.0b013e31815c4037","article-title":"Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid\/distal esophagus: five-year survival of a randomized clinical trial","volume":"246","author":"Omloo","year":"2007","journal-title":"Ann Surg"},{"key":"2024073109230654500_znae160-B7","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/SLA.0b013e3182263781","article-title":"Transthoracic versus transhiatal esophagectomy for the treatment of esophagogastric cancer: a meta-analysis","volume":"254","author":"Boshier","year":"2011","journal-title":"Ann Surg"},{"key":"2024073109230654500_znae160-B8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4321\/S1130-01082012000400005","article-title":"Laparoscopic versus open transhiatal esophagectomy for distal and junction cancer","volume":"104","author":"Maas","year":"2012","journal-title":"Rev Esp Enferm Dig"},{"key":"2024073109230654500_znae160-B9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1245\/s10434-020-08760-8","article-title":"Transthoracic versus transhiatal esophagectomy for esophageal cancer: a nationwide propensity score-matched cohort analysis","volume":"28","author":"Mertens","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"2024073109230654500_znae160-B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dox047","article-title":"Perioperative outcomes of single-port mediastinoscope-assisted transhiatal esophagectomy for thoracic esophageal cancer","volume":"30","author":"Fujiwara","year":"2017","journal-title":"Dis Esophagus"},{"key":"2024073109230654500_znae160-B11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/dote.12345","article-title":"Short-term outcomes of robotic radical esophagectomy for esophageal cancer by a nontransthoracic approach compared with conventional transthoracic surgery","volume":"29","author":"Mori","year":"2016","journal-title":"Dis Esophagus"},{"key":"2024073109230654500_znae160-B12","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s11605-018-04069-w","article-title":"Single-port inflatable mediastinoscopy combined with laparoscopic-assisted small incision surgery for radical esophagectomy is an effective and safe treatment for esophageal cancer","volume":"23","author":"Wang","year":"2019","journal-title":"J Gastrointest Surg"},{"key":"2024073109230654500_znae160-B13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10388-018-00656-7","article-title":"A feasibility study of mediastinoscopic radical esophagectomy for thoracic esophageal cancer from the viewpoint of the dissected mediastinal lymph nodes validated with thoracoscopic procedure: a prospective clinical trial","volume":"16","author":"Tokairin","year":"2019","journal-title":"Esophagus"},{"key":"2024073109230654500_znae160-B14","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/bjs\/znad079","article-title":"Introduction of Minimally Invasive transCervical oEsophagectomy (MICE) according to the IDEAL framework","volume":"110","author":"Klarenbeek","year":"2023","journal-title":"Br J Surg"},{"key":"2024073109230654500_znae160-B15","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1200\/JCO.20.03614","article-title":"Ten-year outcome of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer: the randomized controlled CROSS trial","volume":"39","author":"Eyck","year":"2021","journal-title":"J Clin Oncol"},{"key":"2024073109230654500_znae160-B16","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S1470-2045(15)00040-6","article-title":"Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial","volume":"16","author":"Shapiro","year":"2015","journal-title":"Lancet Oncol"},{"key":"2024073109230654500_znae160-B17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/ALN.0000000000001541","article-title":"Adding examples to the ASA-physical status classification improves correct assignment to patients","volume":"126","author":"Hurwitz","year":"2017","journal-title":"Anesthesiology"},{"key":"2024073109230654500_znae160-B18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"2024073109230654500_znae160-B19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/SLA.0000000000001098","article-title":"International consensus on standardization of data collection for complications associated with esophagectomy: Esophagectomy Complications Consensus Group (ECCG)","volume":"262","author":"Low","year":"2015","journal-title":"Ann Surg"},{"key":"2024073109230654500_znae160-B20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/dote.12375","article-title":"Complications after esophagectomy: it is time to speak the same language","volume":"29","author":"Zaninotto","year":"2016","journal-title":"Dis Esophagus"},{"key":"2024073109230654500_znae160-B21","doi-asserted-by":"crossref","first-page":"doy002","DOI":"10.1093\/dote\/doy002","article-title":"Defining pneumonia after esophagectomy for cancer: validation of the uniform pneumonia score in a high volume center in North America","volume":"31","author":"Seesing","year":"2018","journal-title":"Dis Esophagus"},{"key":"2024073109230654500_znae160-B22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00428-017-2276-y","article-title":"Eighth Edition of the UICC Classification of Malignant Tumours: an overview of the changes in the pathological TNM classification criteria-what has changed and why?","volume":"472","author":"Bertero","year":"2018","journal-title":"Virchows Arch"},{"key":"2024073109230654500_znae160-B23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10388-016-0551-7","article-title":"Japanese Classification of Esophageal Cancer, 11th Edition: part I","volume":"14","author":"Japan Esophageal","year":"2017","journal-title":"Esophagus"},{"key":"2024073109230654500_znae160-B24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10388-016-0556-2","article-title":"Japanese Classification of Esophageal Cancer, 11th Edition: part II and III","volume":"14","author":"Japan Esophageal","year":"2017","journal-title":"Esophagus"},{"key":"2024073109230654500_znae160-B25","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.athoracsur.2015.03.122","article-title":"Single-port mediastinoscopic lymphadenectomy along the left recurrent laryngeal nerve","volume":"100","author":"Fujiwara","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"2024073109230654500_znae160-B26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.21037\/jovs.2016.07.08","article-title":"Mediastinoscope and laparoscope-assisted esophagectomy","volume":"2","author":"Fujiwara","year":"2016","journal-title":"J Vis Surg"},{"key":"2024073109230654500_znae160-B27","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/EDE.0b013e3181577654","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement","volume":"18","author":"von Elm","year":"2007","journal-title":"Epidemiology"},{"key":"2024073109230654500_znae160-B28","doi-asserted-by":"crossref","first-page":"S868","DOI":"10.21037\/jtd.2017.06.92","article-title":"Recurrent laryngeal nerve injury after esophagectomy for esophageal cancer: incidence, management, and impact on short- and long-term outcomes","volume":"9(Suppl 8)","author":"Scholtemeijer","year":"2017","journal-title":"J Thorac Dis"},{"key":"2024073109230654500_znae160-B29","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1007\/s11605-022-05472-0","article-title":"Continuous recurrent laryngeal nerve monitoring during single-port mediastinoscopic radical esophagectomy for esophageal cancer","volume":"26","author":"Komatsu","year":"2022","journal-title":"J Gastrointest Surg"},{"key":"2024073109230654500_znae160-B30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00464-020-07455-1","article-title":"Postoperative recurrent laryngeal nerve palsy is associated with pneumonia in minimally invasive esophagectomy for esophageal cancer","volume":"35","author":"Oshikiri","year":"2021","journal-title":"Surg Endosc"},{"key":"2024073109230654500_znae160-B31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1001\/jamasurg.2021.1555","article-title":"Intrathoracic vs cervical anastomosis after totally or hybrid minimally invasive esophagectomy for esophageal cancer: a randomized clinical trial","volume":"156","author":"van Workum","year":"2021","journal-title":"JAMA Surg"},{"key":"2024073109230654500_znae160-B32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/SLA.0000000000002469","article-title":"Learning curve and associated morbidity of minimally invasive esophagectomy: a retrospective multicenter study","volume":"269","author":"van Workum","year":"2019","journal-title":"Ann Surg"},{"key":"2024073109230654500_znae160-B33","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/SLA.0000000000004801","article-title":"Learning curves of Ivor Lewis totally minimally invasive esophagectomy by hospital and surgeon characteristics: a retrospective multinational cohort study","volume":"275","author":"Claassen","year":"2022","journal-title":"Ann Surg"},{"key":"2024073109230654500_znae160-B34","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0140-6736(09)61116-8","article-title":"No surgical innovation without evaluation: the IDEAL recommendations","volume":"374","author":"McCulloch","year":"2009","journal-title":"Lancet"},{"key":"2024073109230654500_znae160-B35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/bjs.11459","article-title":"Transanal total mesorectal excision for rectal cancer has been suspended in Norway","volume":"107","author":"Wasmuth","year":"2020","journal-title":"Br J Surg"},{"key":"2024073109230654500_znae160-B36","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S2468-1253(19)30004-4","article-title":"Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2\/3 trial","volume":"4","author":"van Hilst","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/7\/znae160\/58693463\/znae160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/111\/7\/znae160\/58693463\/znae160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T01:53:05Z","timestamp":1722477185000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/doi\/10.1093\/bjs\/znae160\/7710628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7,10]]},"published-print":{"date-parts":[[2024,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znae160","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,7]]},"article-number":"znae160"}}