{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:52:46Z","timestamp":1785912766498,"version":"3.56.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Venous thrombosis represents a significant complication after deceased-donor liver transplantation, yet there are currently no established protocols for thromboprophylaxis after deceased-donor liver transplantation. The aim of this study was to evaluate the efficacy and safety of prophylactic anticoagulation in patients undergoing deceased-donor liver transplantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A dual-centre RCT of patients assigned to receive either enoxaparin or normal saline after liver transplantation was conducted. The primary efficacy outcome was the incidence of venous thrombosis (portal vein thrombosis and deep vein thrombosis) and the primary safety outcome was the incidence of major bleeding.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 462 patients were recruited. In the intention-to-treat analysis, 89 patients (19.3%) experienced venous thrombosis and 141 patients (30.5%) experienced major bleeding within 90 days after transplantation. No significant differences were observed in the incidence of venous thrombosis, portal vein thrombosis, or deep vein thrombosis between the two groups in the intention-to-treat cohort. The anticoagulant group demonstrated a markedly elevated incidence of major bleeding (35.5% versus 25.5%, P = 0.020). Subgroup analysis revealed that anticoagulation was associated with a lower risk of deep vein thrombosis in hepatocellular carcinoma patients (HR 0.44 (95% c.i. 0.23 to 0.86), P = 0.016), without a significantly higher risk of major bleeding.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Use of prophylactic anticoagulation with enoxaparin is associated with a significantly higher incidence of major bleeding in patients undergoing deceased-donor liver transplantation, rather than a lower likelihood of venous thrombosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration number<\/jats:title>\n                  <jats:p>ChiCTR2000032441 (www.chictr.org.cn).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znae325","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T10:50:21Z","timestamp":1740394221000},"source":"Crossref","is-referenced-by-count":5,"title":["Comparing the efficacy and safety of thromboprophylaxis with enoxaparin <i>versus<\/i> normal saline after liver transplantation: randomized clinical trial"],"prefix":"10.1093","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6609-0511","authenticated-orcid":false,"given":"Kunlin","family":"Xie","sequence":"first","affiliation":[{"name":"Department of General Surgery, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Liver Transplant Centre, Transplant Centre, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2651-8682","authenticated-orcid":false,"given":"Hongzhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Liver Transplant Centre, Transplant Centre, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China"},{"name":"Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Liver Transplant Centre, Transplant Centre, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-0287","authenticated-orcid":false,"given":"Sheyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Department of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huakang","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Big Data in Health Science, Zhejiang University School of Public Health , Hangzhou ,","place":["China"]},{"name":"Centre of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Liver Transplant Centre, Transplant Centre, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lyv","sequence":"additional","affiliation":[{"name":"Department of General Surgery, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Liver Transplant Centre, Transplant Centre, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4209-9681","authenticated-orcid":false,"given":"Jianguo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyou","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Big Data in Health Science, Zhejiang University School of Public Health , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M","family":"Elgendi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Alexandria University , Alexandria ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred W C","family":"Kow","sequence":"additional","affiliation":[{"name":"Division of HPB Surgery, Department of Surgery, National University of Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Liver Transplant Centre, Transplant Centre, West China Hospital, Sichuan University , Chengdu 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