{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:05:27Z","timestamp":1776395127312,"version":"3.51.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Previous retrospective studies have demonstrated the effectiveness of parenchymal pre-compression in reducing pancreatic fistula after left-sided pancreatic resection; however, no multicentre RCT has been conducted. The aim of this study was to investigate whether pre-compression reduces grade B\/C pancreatic fistula after left-sided pancreatic resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between 23 March 2021 and 26 January 2023, patients scheduled for left-sided pancreatic resection were enrolled in a multicentre RCT at 13 hospitals in Japan. These patients were randomly assigned (1 : 1) to the pre-compression group or the non-compression group. The primary endpoint was the incidence of grade B\/C pancreatic fistula and the secondary endpoint was it in the subgroup.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 180 patients were assigned to the pre-compression group and the non-compression group (92 patients and 88 patients respectively) and 171 patients were analysed (88 patients in the pre-compression group and 83 patients in the non-compression group). Grade B\/C pancreatic fistula was observed in 22 patients (12.9%), including 11 of 88 patients (12.5%) in the pre-compression group and 11 of 83 patients (13.3%) in the non-compression group (OR 0.94 (95% c.i. 0.38 to 2.31); P = 0.883).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A statistically significant difference in the incidence of grade B\/C pancreatic fistula was not observed between the pre-compression group and the non-compression group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration number<\/jats:title>\n                  <jats:p>UMIN000042700 (https:\/\/www.umin.ac.jp).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znaf008","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T21:42:13Z","timestamp":1741124533000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of pre-compression <i>versus<\/i> non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical trial"],"prefix":"10.1093","volume":"112","author":[{"given":"Tatsuaki","family":"Sumiyoshi","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Science, Hiroshima University , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-6268","authenticated-orcid":false,"given":"Kenichiro","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Science, Hiroshima University , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Science, Hiroshima University , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-5409","authenticated-orcid":false,"given":"Sohei","family":"Satoi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kansai Medical University , Hirakata, Osaka ,","place":["Japan"]},{"name":"Division of Surgical Oncology, University of Colorado Anschutz Medical Campus , Aurora, Colorado ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kansai Medical University , Hirakata, Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Oshita","sequence":"additional","affiliation":[{"name":"Department of Surgery, JA Onomichi General Hospital , Onomichi 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Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chugoku Rosai Hospital , Kure ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Surgery, Higashihiroshima Medical Centre , Higashihiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Miyoshi Central Hospital , Miyoshi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiroshima City Hiroshima Citizens Hospital , Hiroshima 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