{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:01:45Z","timestamp":1791583305976,"version":"4.3.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"University Hospital of Southern Denmark"},{"name":"Hospital of Southern Jutland"},{"DOI":"10.13039\/501100006356","name":"University of Southern Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021817","name":"Knud og Edith Eriksens Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to compare robotic-assisted transabdominal preperitoneal (R-TAPP) and conventional laparoscopic transabdominal preperitoneal (L-TAPP) inguinal hernia repair with respect to surgical stress response and short-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-centre, open-label, RCT enrolled patients undergoing elective inguinal hernia repair. Patients were randomized 1 : 1 to R-TAPP or L-TAPP using a computer-generated sequence with block sizes of six. All procedures were performed by the same experienced surgeons. The primary outcome was plasma C-reactive protein (CRP) levels. Secondary outcomes included interleukin 6 (IL-6) levels, operating time, complications, length of stay, and readmission rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 150 patients (R-TAPP, 76; and L-TAPP, 74) were randomized, with 11 withdrawing before surgery, leaving 139 (R-TAPP, 74; and L-TAPP, 65) for intention-to-treat analysis. CRP levels were significantly lower after R-TAPP on postoperative days 1 and 3 (reductions of 23% and 32% respectively, P = 0.001). IL-6 levels were also lower after R-TAPP at 30 and 120 min after extubation (reductions of 26% and 22% respectively, P &amp;lt; 0.001). R-TAPP was associated with a shorter operating time (\u221213.4 min, P &amp;lt; 0.001), fewer complications (23.0% versus 41.5%, P = 0.029), including fewer haematomas (6.8% versus 18.5%, P = 0.043), and a higher same-day discharge rate (95.9% versus 81.5%, P = 0.012). No significant differences were observed regarding chronic pain and recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>R-TAPP was associated with reduced surgical stress, complications, operating time, and hospitalization compared with L-TAPP. These findings support further multicentre trials to assess long-term outcomes and generalizability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration number<\/jats:title>\n                    <jats:p>NCT05839587 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjs\/znaf074","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T10:16:33Z","timestamp":1742465793000},"source":"Crossref","is-referenced-by-count":22,"title":["Inflammatory response and short-term outcomes after laparoscopic\n                    <i>versus<\/i>\n                    robotic transabdominal preperitoneal inguinal hernia repair: randomized clinical trial (ROLAIS)"],"prefix":"10.1093","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0249-3406","authenticated-orcid":false,"given":"Alexandros","family":"Valorenzos","sequence":"first","affiliation":[{"name":"Department of General Surgery, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Regional Health Research, University of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Clinical Research, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Open Patient Data Explorative Network, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian A","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Regional Health Research, University of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Clinical Research, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Clinical Research, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Gynaecology and Obstetrics, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie R","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Clinical Research, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Helligs\u00f8","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Dorfelt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate L","family":"Lambertsen","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark , Odense ,","place":["Denmark"]},{"name":"Department of Neurology, Odense University Hospital , Odense ,","place":["Denmark"]},{"name":"Department of Clinical Research, BRIDGE, Brain Research-Inter-Disciplinary Guided Excellence, University of Southern Denmark , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B","family":"Elleb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital , Odense ,","place":["Denmark"]},{"name":"Research Unit of Surgery, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Regional Health Research, University of Southern Denmark , Aabenraa ,","place":["Denmark"]},{"name":"Department of Clinical Research, University Hospital of Southern Denmark , Aabenraa 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