{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:50:38Z","timestamp":1773809438608,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish Breast Cancer Society","award":["ALFGBG-965050"],"award-info":[{"award-number":["ALFGBG-965050"]}]},{"DOI":"10.13039\/100007212","name":"Region V\u00e4stra G\u00f6taland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish state and seven Swedish"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sentinel lymph node (SLN) staging is essential in breast cancer. Superparamagnetic iron oxide nanoparticles (SPIO) is a tracer where the optimal injection technique is yet not defined. The aim was to evaluate SLN detection using 0.1\u2005ml SPIO intradermally compared to technetium-99\u2005m (Tc99) \u00b1 blue dye.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Patients planned for breast surgery and SLN biopsy received 0.1\u2005ml SPIO intradermally at the areolar border or over the tumour. Tc99 \u00b1 blue dye was administered per clinical routine. Magnetic, radioactive, or blue nodes were removed and analysed separately. SLN detection and numbers, concordance, and skin discoloration were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 216 patients were included at five hospitals. Median age was 63 years, tumour size 15.9\u2005mm, and 91.7% underwent breast conservation. SPIO was injected a median of 12 days before surgery. SLN detection was 211\/216 (97.7%; 95% c.i.: 94.7 to 99.2) and 215\/216 (99.5%; 95% c.i.: 98.6 to 100.0) for SPIO and Tc99 \u00b1 blue dye (P = 0.111) respectively. In total, 403 SLNs were removed; 341 detected by SPIO and 349 by Tc99 \u00b1 blue dye. The median number of SLNs was 1 (iqr: 1\u20132) for both tracer methods. Among 46 SLN-positive patients, 42 were correctly staged with both tracers, two with SPIO only and two with Tc99 \u00b1 blue dye only. Skin discoloration was evaluated in 107 patients. The median discoloured area was 0\u2005cm2 (iqr: 0\u20130.7) among 49 patients with the injection site surgically removed and 1.3\u2005cm2 (iqr: 0.6\u20132.8) among 58 without removal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An ultra-low dose of 0.1\u2005ml intradermal injection of SPIO was non-inferior to Tc99 \u00b1 blue dye for SLN detection. Skin discoloration was limited and further reduced by removal during surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znaf129","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:12:55Z","timestamp":1753269175000},"source":"Crossref","is-referenced-by-count":6,"title":["Ultra-low dose superparamagnetic iron oxide nanoparticle injection for sentinel lymph node detection in breast cancer: prospective cohort study"],"prefix":"10.1093","volume":"112","author":[{"given":"Lovisa","family":"Sundh","sequence":"first","affiliation":[{"name":"Department of Surgery, Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital , Gothenburg ,","place":["Sweden"]},{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg 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Hospital , Lidk\u00f6ping ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-3575","authenticated-orcid":false,"given":"Andreas","family":"Karakatsanis","sequence":"additional","affiliation":[{"name":"Section for Breast Surgery, Department of Surgical Sciences, Uppsala University Hospital , Uppsala ,","place":["Sweden"]},{"name":"Department of Surgical Sciences, Uppsala University , Uppsala ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Section for Breast Surgery, Department of Surgery, V\u00e4stmanland County Hospital , V\u00e4ster\u00e5s ,","place":["Sweden"]},{"name":"Section for Breast Surgery, Department of Surgical Sciences, Uppsala University Hospital , Uppsala 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