{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:58:58Z","timestamp":1773554338978,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Multicystic peritoneal mesothelioma (MCPM) is a rare neoplasm, generally considered a borderline malignancy, best treated by cytoreductive surgery (CRS) to remove macroscopic disease, combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Owing to its rarity, little has been published on clinical presentation, clinical behaviour over time, or an optimal treatment approach.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospectively developed peritoneal malignancy database was interrogated for the years 2001\u20132018. Details on all patients with MCPM as a definitive diagnosis after CRS and HIPEC were analysed, including previous interventions, mode of presentation, surgical treatment, postoperative outcomes, and late follow-up information from abdominal CT and tumour markers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 40 patients with MCPM underwent CRS and HIPEC between 2001 and 2018. Of these, 32 presented with abdominal pain, distension or bloating, six patients presented with recurrence following previous surgery at the referring hospitals, and two had coincidental diagnoses during a surgical procedure. CRS involved peritonectomy in all 40 patients. Bowel resection was required in 18 patients, and seven had a temporary stoma. Thirty-eight patients were considered to have undergone a complete macroscopic tumour removal (completeness of cytoreduction CC0), and two had residual tumour nodules less than 2.5\u00a0mm in size, classified as CC1. Median duration of follow-up was 65 (range 48\u201379)\u00a0months. There were no deaths during follow-up. The Kaplan\u2013Meier-predicted recurrence-free interval was 115.4\u00a0months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>MCPM is a rare peritoneal neoplasm with a heterogeneous pattern of presentation. CRS and HIPEC is an effective management option for this group of patients, with favourable long-term survival.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraa001","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T10:48:44Z","timestamp":1615373324000},"source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of multicystic peritoneal mesothelioma treatment with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-416X","authenticated-orcid":false,"given":"A","family":"Zahid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-7174","authenticated-orcid":false,"given":"L","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Chandrakumaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tzivanakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dayal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Cecil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2022071109162914600_zraa001-B1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.currproblcancer.2017.03.002","article-title":"Multicystic peritoneal mesothelioma: a short review","volume":"41","author":"Zhang","year":"2017","journal-title":"Curr Probl Cancer"},{"key":"2022071109162914600_zraa001-B2","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1097-0142(197908)44:2<692::AID-CNCR2820440242>3.0.CO;2-6","article-title":"Multicystic, peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma","volume":"44","author":"Mennemeyer","year":"1979","journal-title":"Cancer"},{"key":"2022071109162914600_zraa001-B3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/hupa.2003.31","article-title":"Benign cystic mesothelioma of the peritoneum: a clinicopathologic study of 17 cases and immunohistochemical analysis of estrogen and progesterone receptor status","volume":"34","author":"Sawh","year":"2003","journal-title":"Hum Pathol"},{"key":"2022071109162914600_zraa001-B4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/PGP.0b013e3181f99def","article-title":"Multicystic mesothelioma caused by endometriosis: 2 case reports and review of the literature","volume":"30","author":"Kurisu","year":"2011","journal-title":"Int J Gynecol Pathol"},{"key":"2022071109162914600_zraa001-B5","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1447-0756.2010.01474.x","article-title":"Benign cystic mesothelioma: a case series with one case complicated by pregnancy","volume":"37","author":"Akbayir","year":"2011","journal-title":"J Obstet Gynaecol Res"},{"key":"2022071109162914600_zraa001-B6","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.ejso.2018.03.004","article-title":"Multicystic mesothelioma: operative and long-term outcomes with cytoreductive surgery and hyperthermic intra peritoneal chemotherapy","volume":"44","author":"Nizri","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"2022071109162914600_zraa001-B7","first-page":"55","article-title":"Benign multicystic peritoneal mesothelioma: a rare case presenting as pneumoperitoneum and pneumotosis intestinalis. 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