{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:39:16Z","timestamp":1787647156097,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (pHPT) is a common endocrine pathology, and it is due to a single parathyroid adenoma in 80\u201385 per cent of patients. Near-infrared autofluorescence (NIRAF) has recently been used in endocrine surgery to help in the identification of parathyroid tissue, although there is currently no consensus on whether this technique can differentiate between normal and abnormal parathyroid glands. The aim of this study was to describe the autofluorescence pattern of parathyroid adenoma in pHPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January and June 2019, patients with pHPT who underwent surgical treatment for parathyroid adenoma were enrolled. Parathyroid autofluorescence was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-three patients with histologically confirmed parathyroid adenomas were included. Parathyroid adenomas showed a heterogeneous fluorescence pattern, and a well defined autofluorescent \u2018cap\u2019 region was observed in 17 of 23 specimens. This region was on average 28 per cent more fluorescent than the rest of the adenoma, and corresponded to a rim of normal histological parathyroid tissue (sensitivity and specificity 88 and 67 per cent respectively). After resection, all patients were treated successfully, with normal postoperative values of calcium and parathyroid hormone documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Parathyroid adenomas show a heterogeneous autofluorescence pattern. Using NIRAF imaging, the majority of specimens showed a well defined autofluorescent portion corresponding to a rim of normal parathyroid tissue. Further studies should be conducted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraa047","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T07:56:42Z","timestamp":1613635002000},"source":"Crossref","is-referenced-by-count":41,"title":["Autofluorescence pattern of parathyroid adenomas"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-2980","authenticated-orcid":false,"given":"M S","family":"Demarchi","sequence":"first","affiliation":[{"name":"Department of Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Karenovics","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"B\u00e9dat","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"De Vito","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology, Geneva University Hospitals , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Triponez","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva , Geneva, 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