{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:01:09Z","timestamp":1783555269056,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Vatsatautien Tutkimuss\u00e4\u00e4ti\u00f6 Foundation"},{"name":"Mary and Georg Ehrnrooth\u2019s Foundation"},{"name":"Finnish Cancer Foundation, and Helsinki University Research Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In retrospective series, mechanical and oral antibiotic bowel preparation (MOABP) has been reported to reduce surgical-site infections (SSIs) after colectomy compared with no bowel preparation (NBP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>This was a subgroup analysis of a multicentre randomized trial that included patients scheduled for elective colectomy. The MOABP group underwent mechanical bowel preparation, and took 2 g neomycin and 2 g metronidazole orally during the day before surgery. The NBP group did not undergo bowel preparation. Patients were categorized according to the side of resection (right versus left colectomy), and these subgroups compared for postoperative outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 217 patients undergoing right colectomy (106 in MOABP and 111 in NBP group), SSI was detected in seven (7 per cent) and 10 (9 per cent) patients (odds ratio (OR) 0.71, 95 per cent c.i. 0.26 to 1.95; P\u2009=\u20090.510), anastomotic dehiscence in two (2 per cent) and two (2 per cent) patients (OR 1.05, 0.15 to 7.58; P\u2009=\u20091.000), and the mean(s.d.) Comprehensive Complication Index (CCI) score was 9.4(12.9) and 10.5(18.0) (mean difference \u20131.09; 95 per cent c.i. \u20135.29 to 3.11; P\u2009=\u20090.608) in the MOABP and NBP groups respectively. Among 164 patients undergoing left colectomy (84 in MOABP and 80 in NBP group), SSI was detected in five (6 per cent) and eight (10 per cent) patients (OR 0.57, 0.18 to 1.82; P\u2009=\u20090.338), anastomotic dehiscence in four (5 per cent) and five (6 per cent) patients (OR 0.75, 0.19 to 2.90; P\u2009=\u20090.742), and the CCI score was 10.2(13.1) and 6.5(11.0) (mean difference 3.68, \u20130.06 to 7.42; P\u2009=\u20090.053) in the MOABP and NBP groups respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MOABP did not decrease the rate of SSI or complications in patients undergoing either right or left colectomy compared with NBP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrab011","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T03:34:31Z","timestamp":1612409671000},"source":"Crossref","is-referenced-by-count":16,"title":["Mechanical and oral antibiotic bowel preparation <i>versus<\/i> no bowel preparation in right and left colectomy: subgroup analysis of MOBILE trial"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-7942","authenticated-orcid":false,"given":"L","family":"Koskenvuo","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Lehtonen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Koskensalo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rasilainen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Klintrup","sequence":"additional","affiliation":[{"name":"Department of Surgery, Surgical Research Unit, Medical Research Centre, Oulu University Hospital, University of Oulu , Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Central Hospital of Central Finland , Jyv\u00e4skyl\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Pinta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sein\u00e4joki Central Hospital , Sein\u00e4joki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Scheinin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Sallinen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,11]]},"reference":[{"key":"2023020209542077500_zrab011-B1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/SLA.0000000000001041","article-title":"Combined mechanical and oral antibiotic bowel preparation reduces incisional surgical site infection and anastomotic leak rates after elective colorectal resection: an analysis of colectomy-targeted ACS NSQIP","volume":"262","author":"Scarborough","year":"2015","journal-title":"Ann Surg"},{"key":"2023020209542077500_zrab011-B2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/SLA.0000000000002568","article-title":"The role of bowel preparation in colorectal surgery: results of the 2012-2015 ACS-NSQIP data","volume":"269","author":"Klinger","year":"2019","journal-title":"Ann 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