{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:26Z","timestamp":1787008526621,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Arterial hyperflow to haemorrhoids has been implicated as a possible pathophysiological co-factor in haemorrhoidal disease. The purpose of this study was to investigate how transanal haemorrhoidal dearterialization (THD) can influence haemodynamic parameters at the level of the haemorrhoidal piles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with grade III haemorrhoids selected for THD between July and December 2018 were evaluated using endoanal ultrasonography and colour Doppler imaging at the level of internal haemorrhoids before and 1 year after the surgical procedure. Peak systolic velocity, pulsatility index, resistivity index, acceleration time, and end-diastolic velocity were measured, and preoperative and postoperative values compared. Symptom severity was measured using a symptom-based questionnaire (score range 0\u201320).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 21 patients treated, 17 completed the study. Compared with preoperative values, postoperative peak systolic velocity (mean(s.d.) 18.7(1.1) versus 10.3(0.4) cm\/s; P\u2009&amp;lt;\u20090.05), pulsatility index (5.5(0.3) versus 2.8(0.4); P\u2009&amp;lt;\u20090.050), and resistivity index (1.0(0.2) versus 0.8(0.5); P\u2009&amp;lt;\u20090.050) decreased significantly, whereas acceleration time increased significantly (65.6(3.6) versus 83.3(4.7) cm\/s2; P\u2009&amp;lt;\u20090.050); end-diastolic velocity did not change (1.9(0.2) versus 2.0(0.4); P\u2009=\u20090.753). Symptoms disappeared or had improved significantly in all patients by 1 year after surgery. The mean(s.d.) total symptom severity score decreased from 15.8(1.1) to 1.2(1.6) (P\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>THD affects the main haemodynamic parameters at the level of internal haemorrhoids and is associated with a decrease in arterial hyperflow.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrab012","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T13:50:02Z","timestamp":1612965002000},"source":"Crossref","is-referenced-by-count":12,"title":["Haemorrhoidal haemodynamic changes in patients with haemorrhoids treated using Doppler-guided dearterialization"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-9158","authenticated-orcid":false,"given":"A","family":"Parello","sequence":"first","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-621X","authenticated-orcid":false,"given":"F","family":"Litta","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-2640","authenticated-orcid":false,"given":"V","family":"De Simone","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Campenn\u00ec","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Orefice","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-5081","authenticated-orcid":false,"given":"A A","family":"Marra","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Goglia","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Santoro","sequence":"additional","affiliation":[{"name":"Medical Vascular Disease Clinic Unit, Fondazione Policlinico A. Gemelli IRCSS , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Santoliquido","sequence":"additional","affiliation":[{"name":"Medical Vascular Disease Clinic Unit, Fondazione Policlinico A. Gemelli IRCSS , Rome, Italy"},{"name":"Catholic University of the Sacred Heart , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-0037","authenticated-orcid":false,"given":"C","family":"Ratto","sequence":"additional","affiliation":[{"name":"Proctology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS , Rome, Italy"},{"name":"Catholic University of the Sacred Heart , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,11]]},"reference":[{"key":"2022071109272249600_zrab012-B1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.amjsurg.2002.11.003","article-title":"The superior rectal artery and its branching pattern with regard to its clinical influence on ligation techniques for internal hemorrhoids","volume":"187","author":"Aigner","year":"2004","journal-title":"Am J Surg"},{"key":"2022071109272249600_zrab012-B2","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.gassur.2005.12.004","article-title":"The vascular nature of hemorrhoids","volume":"10","author":"Aigner","year":"2006","journal-title":"J Gastrointest Surg"},{"key":"2022071109272249600_zrab012-B3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00384-008-0572-3","article-title":"Revised morphology and hemodynamics of the anorectal vascular plexus: impact on the course of hemorrhoidal disease","volume":"24","author":"Aigner","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"2022071109272249600_zrab012-B4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/bjs.7700","article-title":"Assessment of haemorrhoidal artery network using colour duplex imaging and clinical implications","volume":"99","author":"Ratto","year":"2012","journal-title":"Br J Surg"},{"key":"2022071109272249600_zrab012-B5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10151-013-1062-3","article-title":"THD Doppler procedure for hemorrhoids: the surgical technique","volume":"18","author":"Ratto","year":"2014","journal-title":"Tech Coloproctol"},{"key":"2022071109272249600_zrab012-B6","doi-asserted-by":"crossref","first-page":"e786","DOI":"10.1111\/j.1463-1318.2012.03146.x","article-title":"\u2018Distal Doppler-guided dearterialization\u2019 is highly effective in treating haemorrhoids by transanal haemorrhoidal dearterialization","volume":"14","author":"Ratto","year":"2012","journal-title":"Colorectal Dis"},{"key":"2022071109272249600_zrab012-B7","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s10151-017-1726-5","article-title":"Transanal hemorrhoidal dearterialization (THD) for hemorrhoidal disease: a single-center study on 1000 consecutive cases and a review of the literature","volume":"21","author":"Ratto","year":"2017","journal-title":"Tech Coloproctol"},{"key":"2022071109272249600_zrab012-B8","doi-asserted-by":"crossref","first-page":"O10","DOI":"10.1111\/codi.12779","article-title":"Doppler-guided transanal haemorrhoidal dearterialization for haemorrhoids: results from a multicentre trial","volume":"17","author":"Ratto","year":"2015","journal-title":"Colorectal Dis"},{"key":"2022071109272249600_zrab012-B9","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1111\/codi.12205","article-title":"Clinical outcome following Doppler-guided haemorrhoidal artery ligation: a systematic review","volume":"15","author":"Pucher","year":"2013","journal-title":"Colorectal Dis"},{"key":"2022071109272249600_zrab012-B10","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/bjs.9913","article-title":"Systematic review and network meta-analysis comparing clinical outcomes and effectiveness of surgical treatments for haemorrhoids","volume":"102","author":"Simillis","year":"2015","journal-title":"Br J Surg"}],"container-title":["BJS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/5\/2\/zrab012\/44815324\/zrab012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/5\/2\/zrab012\/44815324\/zrab012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T05:28:09Z","timestamp":1657517289000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjsopen\/article\/doi\/10.1093\/bjsopen\/zrab012\/6220256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/bjsopen\/zrab012","relation":{},"ISSN":["2474-9842"],"issn-type":[{"value":"2474-9842","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3]]},"published":{"date-parts":[[2021,3]]},"article-number":"zrab012"}}