{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:21:18Z","timestamp":1763400078289,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Phaeochromocytomas are rare tumours with a recurrence after open surgery ranging between 6\u201323 per cent. Long-term follow-up studies after laparoscopic surgery for phaeochromocytoma are lacking. The aim of this study was to look at the long-term oncological outcome of a consecutive series of patients from a single centre undergoing laparoscopic surgery for a phaeochromocytoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic data on all patients with an adrenal tumour or paraganglioma were prospectively kept on a database between September 1999 and December 2017. Electronic hospital records, including imaging from a national linked archiving and communication system, were reviewed for patients with a phaeochromocytoma in November 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study interval 135 patients with a phaeochromocytoma were operated on in the unit, of which 118 (87.4 per cent) were attempted laparoscopically. Five (4.2 per cent) were converted to open surgery, whereas 117 had a potentially curative operation. There was no peri- or postoperative mortality. At a median follow-up of 10 (interquartile range 6\u201312.9) years, only 3 (2.6 per cent) patients died from metastatic phaeochromocytoma. One further patient developed lymph node metastases, which were removed at open surgery. No patient had a local recurrence and the only significant predictor of recurrence was the presence of lymph node metastases (P\u2009&amp;lt;\u20090.001). Two patients developed a contralateral adrenal phaeochromocytoma, while one of these also had a paraganglioma. The Kaplan\u2013Meier estimate of phaeochromocytoma-free survival was 96 per cent (95 per cent c.i. 92.2 to 98.8) at 5 years and 92 per cent (95 per cent c.i. 86.7 to 97.3) at 10 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that long-term oncological outcomes of laparoscopic surgery for patients with a phaeochromocytoma are at least as good as that with an open operation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bjsopen\/zrac076","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T11:14:50Z","timestamp":1651058090000},"source":"Crossref","is-referenced-by-count":6,"title":["Long-term follow-up of patients undergoing laparoscopic surgery for phaeochromocytoma"],"prefix":"10.1093","volume":"6","author":[{"given":"Patrick J","family":"O\u2019Dwyer","sequence":"first","affiliation":[{"name":"School of Medicine, Dentistry and Medicine, University of Glasgow , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Hairmyres , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Zino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ninewells Hospital , Dundee , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G","family":"Serpell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, University of Glasgow , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"2023040517253194100_","first-page":"222","article-title":"Milestones in the evolution of phaechromocytoma diagnosis","volume":"31","author":"Tormey","year":"2002","journal-title":"J Ir Coll Physicians Surg"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1200\/JCO.2005.03.1484","article-title":"Genetic testing in pheochromocytoma or functional paraganglioma","volume":"23","author":"Amar","year":"2005","journal-title":"J Clin Oncol"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/bjs.1800660704","article-title":"Phaechromocytomas in 72 patients: clinical and diagnostic features, treatment and long-term results","volume":"66","author":"Modlin","year":"1979","journal-title":"Br J Surg"},{"key":"2023040517253194100_","first-page":"1061","article-title":"Oncologic aspects of pheochromocytoma: the importance of follow up","volume":"96","author":"Scott","year":"1984","journal-title":"Surgery"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF01658516","article-title":"Long-term evaluation following resection of apparently benign pheochromocytoma(s) or paraganglioma(s)","volume":"14","author":"van Heerdan","year":"1990","journal-title":"World J Surg"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/01.HYP.29.5.1133","article-title":"Tumor recurrence and hypertension persistence after successful pheochromocytoma operation","volume":"29","author":"Plouin","year":"1997","journal-title":"Hypertension"},{"key":"2023040517253194100_","article-title":"Laparoscopic adrenalectomy in Cushing\u2019s syndrome and pheochromocytoma","volume":"327","author":"Gagner","year":"1992","journal-title":"N Engl J Med"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00464-007-9709-7","article-title":"The role of laparoscopic adrenalectomy for tumours of 6 cm or greater","volume":"22","author":"Parnaby","year":"2008","journal-title":"Surg Endosc"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.surge.2009.10.009","article-title":"Perioperative haemodynamic changes in patients undergoing laparoscopic adrenalectomy for phaechromocytomas and other adrenal tumours","volume":"8","author":"Parnaby","year":"2010","journal-title":"Surgeon"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1007\/s00464-013-3013-5","article-title":"Laparoscopic resection of paraaortic or paracaval lesions:feasibility and outcome","volume":"27","author":"Chung","year":"2013","journal-title":"Surg Endosc"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/00000478-200205000-00002","article-title":"Pheochromocytoma of the adrenal gland scale PASS to separate benign from malignant tumors. A clinicopathologic and immunophentypic study of 100 cases","volume":"26","author":"Thompson","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1210\/jc.2010-1946","article-title":"Clinical risk factors for malignancy and overall survival in patients with pheochromocytoma and sympathetic paragangliomas: primary tumour size and primary location as prognostic indicitors","volume":"96","author":"Ayala-Ramires","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0033","article-title":"European Society of Endocrinology Clinical Practise guideline for long-term follow up on patients operated on for a phaeochromocytoma or paraganglioma","volume":"174","author":"Plouin","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/s41436-020-0921-3","article-title":"Tumour detection rates in individuals with SDHx-related paraganglioma\u2013phaeochromocytoma syndrome","volume":"22","author":"Greenberg","year":"2020","journal-title":"Genet Med"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11906-012-0246-y","volume":"14","author":"Eisenhofer","year":"2012","journal-title":"Curr Hypertens Rep"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12957-019-1649-x","article-title":"Comparison of retroperitoneal versus open adrenalectomy for large phaeochromocytoma: a single center retrospective study","volume":"17","author":"Zhu","year":"2019","journal-title":"World J Surg Oncol"},{"key":"2023040517253194100_","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s12020-018-1734-x","article-title":"Treatment and outcomes in phaeochromocytomas and paragangliomas. 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