{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:45:12Z","timestamp":1792597512349,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the impact of all minor and major complications on treatment-related healthcare costs in patients who undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of colorectal peritoneal metastases (PMs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Patients with histologically proven colorectal PMs who underwent CRS\u2009+\u2009HIPEC from March 2006 to October 2019 in a tertiary referral centre were retrospectively identified from a prospectively maintained database. Patients were divided into six subgroups according to the severity of the complications, which were scored using the comprehensive complication index (CCI) (CCI 0\u20139.9, CCI 10\u201319.9, CCI 20\u201329.9, CCI 30\u201339.9, CCI 40\u201349.9, and CCI 50 or higher). Treatment-related healthcare costs up to 1 year after CRS\u2009+\u2009HIPEC were obtained from the financial department. Differences in costs and survival outcomes were compared using the chi-squared test and Kruskal\u2013Wallis H test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 142 patients were included (CCI 0\u20139.9, 53 patients; CCI 10\u201319.9, 0 patients; CCI 20\u201329.9, 45 patients; CCI 30\u201339.9, 14 patients; CCI 40\u201349, 9 patients; and CCI 50 or higher, 21 patients). Median (interquartile range) treatment-related healthcare costs increased significantly and exponentially for the CCI 30\u201339, CCI 40\u201349, and CCI 50 or higher groups (\u20ac48\u2009993 (\u20ac44\u2009262\u2013\u20ac84\u2009805); \u20ac57\u2009167 (\u20ac43\u2009047\u2013\u20ac67\u2009591); and \u20ac82\u2009219 (\u20ac55\u2009487\u2013\u20ac145\u2009314) respectively) compared with those for the CCI 0\u20139.9 and CCI 20\u201329.9 groups (\u20ac33\u2009856 (\u20ac24\u2009433\u2013\u20ac40\u2009779) and \u20ac40\u2009621 (\u20ac31\u2009501\u2013\u20ac58\u2009761) respectively, P\u2009&amp;lt;\u20090.010).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Treatment-related healthcare costs increase exponentially as more complications develop among patients who undergo CRS\u2009+\u2009HIPEC for the treatment of colorectal PMs. Anastomotic leakages after CRS\u2009+\u2009HIPEC lead to an increase of 295 per cent of treatment-related healthcare costs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrac109","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T11:56:03Z","timestamp":1665489363000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of cumulative complications on 1-year treatment-related healthcare costs in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-5355","authenticated-orcid":false,"given":"Femke A","family":"van der Zant","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob J L","family":"Kooijman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E K R","family":"Hentzen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Isala Hospital , Zwolle , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-3995","authenticated-orcid":false,"given":"Wijnand","family":"Helfrich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Laboratory for Translational Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M","family":"Ploeg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Laboratory for Translational Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"van Ginkel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-7431","authenticated-orcid":false,"given":"Lukas B","family":"Been","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost M","family":"Klaase","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatopancreatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick H J","family":"Hemmer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian S","family":"van der Hilst","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatopancreatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schelto","family":"Kruijff","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"2023020302204230200_zrac109-B1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/jso.23722","article-title":"American Society of Peritoneal Surface Malignancies opinion statement on defining expectations from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with colorectal cancer","volume":"110","author":"Esquivel","year":"2014","journal-title":"J Surg Oncol"},{"key":"2023020302204230200_zrac109-B2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1200\/JCO.2008.19.7160","article-title":"Complete 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