{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:44:19Z","timestamp":1780548259242,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009757","name":"H.K.H. Kronprinsessan Lovisas F\u00f6rening f\u00f6r Barnasjukv\u00e5rd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020325","name":"S\u00e4llskapet Barnav\u00e5rd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020325","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Birgitta och Carl-Axel Rydbecks Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to assess fertility in patients treated for Hirschsprung\u2019s disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a nationwide, population-based cohort study, including all patients with Hirschsprung\u2019s disease registered in the Swedish National Patient Register between 1964 and 2004. Five age- and sex-matched controls per patient were randomly selected by Statistics Sweden. Outcome data were retrieved from the Multi-Generation Register, and the Swedish National Patient Register. Study exposure was Hirschsprung\u2019s disease and the primary outcome was fertility, defined as having one or more children. Individuals with chromosomal anomalies were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study cohort comprised 597 patients with Hirschsprung\u2019s disease (143 female) and 2969 controls (714 female). The mean(s.d.) age at follow-up was 29.6(10.0) years for patients and 29.8(10.1) years for the controls. A total of 191 (32.0 per cent) patients compared with 1072 (36.1 per cent) controls had one or more children (P = 0.061). The analysis showed that fewer female patients with Hirschsprung\u2019s disease had a child (29.4 versus 38.7 per cent, P = 0.037), they were older when they gave birth to their first child (28.1 versus 26.4 years, P = 0.033), and they had fewer children. Of the female patients with Hirschsprung\u2019s disease, 19 (45.2 per cent) had only one child, compared with 79 (28.6 per cent) of the female control group (P = 0.047). No difference was noted in the male group in this regard.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Female patients with Hirschsprung\u2019s disease were less likely to have a child, had fewer children, and were older when they gave birth to their first child compared with the controls, indicating impaired fertility. There was no significant difference between male patients with Hirschsprung's disease and controls.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrad043","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T09:46:34Z","timestamp":1686303994000},"source":"Crossref","is-referenced-by-count":9,"title":["Fertility in patients with Hirschsprung's disease: population-based cohort study"],"prefix":"10.1093","volume":"7","author":[{"given":"Cornelia","family":"Bystr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"\u00d6rtqvist","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Unit of Paediatric Surgery, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gunnarsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Unit of Paediatric Surgery, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Wester","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Unit of Paediatric Surgery, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"L\u00f6f Granstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Unit of Paediatric Surgery, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,9]]},"container-title":["BJS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/7\/3\/zrad043\/50552777\/zrad043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/7\/3\/zrad043\/50552777\/zrad043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T09:46:38Z","timestamp":1686303998000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjsopen\/article\/doi\/10.1093\/bjsopen\/zrad043\/7192540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5,5]]}},"URL":"https:\/\/doi.org\/10.1093\/bjsopen\/zrad043","relation":{},"ISSN":["2474-9842"],"issn-type":[{"value":"2474-9842","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,5,5]]},"article-number":"zrad043"}}