{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:04:23Z","timestamp":1790611463502,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Incisional hernia is a common short- and long-term complication of laparotomy and can lead to significant morbidity. The aim of this systematic review and meta-analysis is to provide an up-to-date overview of the laparotomy closure method in elective and emergency settings with the prophylactic mesh augmentation technique.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Scopus, PubMed, and Web of Science databases were screened without time restrictions up to 21 June 2022 using the keywords \u2018laparotomy closure\u2019, \u2018mesh\u2019, \u2018mesh positioning\u2019, and \u2018prophylactic mesh\u2019, and including medical subject headings terms. Only RCTs reporting the incidence of incisional hernia and other wound complications after elective or emergency midline laparotomy, where patients were treated with prophylactic mesh augmentation or without mesh positioning, were included. The primary endpoint was to explore the risk of incisional hernia at different follow-up time points. The secondary endpoint was the risk of wound complications. The risk of bias for individual studies was assessed according to the Revised Cochrane risk-of-bias tools for randomized trials.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighteen RCTs, including 2659 patients, were retrieved. A reduction in the risk of incisional hernia at every time point was highlighted in the prophylactic mesh augmentation group (1 year, risk ratio 0.31, P = 0.0011; 2 years, risk ratio 0.44, P &amp;lt; 0.0001; 3 years, risk ratio 0.38, P = 0.0026; 4 years, risk ratio 0.38, P = 0.0257). An increased risk of wound complications was highlighted for patients undergoing mesh augmentation, although this was not significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Midline laparotomy closure with prophylactic mesh augmentation can be considered safe and effective in reducing the incidence of incisional hernia. Further trials are needed to identify the ideal type of mesh and technique for mesh positioning, but surgeons should consider prophylactic mesh augmentation to decrease incisional hernia rate, especially in high-risk patients for fascial dehiscence and even in emergency settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration ID<\/jats:title>\n                  <jats:p>CRD42022336242 (https:\/\/www.crd.york.ac.uk\/prospero\/record_email.php).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrad060","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T13:08:02Z","timestamp":1690549682000},"source":"Crossref","is-referenced-by-count":18,"title":["Prophylactic mesh augmentation after laparotomy for elective and emergency surgery: meta-analysis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-7401","authenticated-orcid":false,"given":"Simone","family":"Frassini","sequence":"first","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Calabretto","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-3400","authenticated-orcid":false,"given":"Stefano","family":"Granieri","sequence":"additional","affiliation":[{"name":"General Surgery Unit, ASST-Brianza, Vimercate Hospital , Vimercate , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-9276","authenticated-orcid":false,"given":"Paola","family":"Fugazzola","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Massaro","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Sargenti","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Schiavone","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Zangh\u00ec","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Dal Mas","sequence":"additional","affiliation":[{"name":"Department of Management, Universit\u00e0 Ca\u2019 Foscari , Venezia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ansaloni","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cobianchi","sequence":"additional","affiliation":[{"name":"General Surgery Residency, University of Pavia , Pavia , Italy"},{"name":"Unit of General Surgery I, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"2023072812242169700_zrad060-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10029-014-1342-5","article-title":"European Hernia Society guidelines on the closure of abdominal wall incisions","volume":"19","author":"Muysoms","year":"2015","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B2","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/bjs\/znac302","article-title":"Updated guideline for closure of abdominal wall incisions from the European and American Hernia Societies","volume":"109","author":"Deerenberg","year":"2022","journal-title":"Br J Surg"},{"key":"2023072812242169700_zrad060-B3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10029-020-02294-4","article-title":"Management of abdominal wound dehiscence: update of the literature and meta-analysis","volume":"25","author":"Denys","year":"2021","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B4","article-title":"Closure methods for laparotomy incisions for preventing incisional hernias and other wound complications","volume":"11","author":"Patel","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2023072812242169700_zrad060-B5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s10029-013-1119-2","article-title":"Systematic review and meta-analysis of prophylactic mesh placement for prevention of incisional hernia following midline laparotomy","volume":"17","author":"Bhangu","year":"2013","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/jamasurg.2018.4221","article-title":"Effectiveness of prophylactic intraperitoneal mesh implantation for prevention of incisional hernia in patients undergoing open abdominal surgery: a randomized clinical trial","volume":"154","author":"Kohler","year":"2019","journal-title":"JAMA Surg"},{"key":"2023072812242169700_zrad060-B7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10029-017-1653-4","article-title":"Meta-analysis of randomised trials comparing the use of prophylactic mesh to standard midline closure in the reduction of incisional herniae","volume":"21","author":"Payne","year":"2017","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B8","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/bjs.9600","article-title":"Incidence of and risk factors for incisional hernia after abdominal surgery","volume":"101","author":"Itatsu","year":"2014","journal-title":"Br J Surg"},{"key":"2023072812242169700_zrad060-B9","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10029-016-1480-z","article-title":"The economic burden of incisional ventral hernia repair: a multicentric cost analysis","volume":"20","author":"Gillion","year":"2016","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B10","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s11605-013-2233-2","article-title":"Long-term outcome study in patients with abdominal wound dehiscence: a comparative study on quality of life, body image, and incisional hernia","volume":"17","author":"van Ramshorst","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"2023072812242169700_zrad060-B11","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00423-021-02421-4","article-title":"Efficacy and safety of mesh closure in preventing wound failure following emergency laparotomy: a systematic review and meta-analysis","volume":"407","author":"Albendary","year":"2022","journal-title":"Langenbecks Arch Surg"},{"key":"2023072812242169700_zrad060-B12","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s00268-020-05898-0","article-title":"Prophylactic mesh after midline laparotomy: evidence is out there, but why do surgeons hesitate?","volume":"45","author":"Depuydt","year":"2021","journal-title":"World J Surg"},{"key":"2023072812242169700_zrad060-B13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jamcollsurg.2014.12.027","article-title":"Development and validation of a risk stratification score for ventral incisional hernia after abdominal surgery: hernia expectation rates in intra-abdominal surgery (the HERNIA project)","volume":"220","author":"Goodenough","year":"2015","journal-title":"J Am Coll Surg"},{"key":"2023072812242169700_zrad060-B14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/TA.0000000000001970","article-title":"Interrupted versus continuous fascial closure in patients undergoing emergent laparotomy: a randomized controlled trial","volume":"85","author":"Peponis","year":"2018","journal-title":"J Trauma Acute Care Surg"},{"key":"2023072812242169700_zrad060-B15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/SLA.0000000000001762","article-title":"Reduced rate of dehiscence after implementation of a standardized fascial closure technique in patients undergoing emergency laparotomy","volume":"265","author":"Tolstrup","year":"2017","journal-title":"Ann Surg"},{"key":"2023072812242169700_zrad060-B16","first-page":"e123","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"3","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"2023072812242169700_zrad060-B17","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2023072812242169700_zrad060-B18","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"2023072812242169700_zrad060-B19","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"2023072812242169700_zrad060-B20","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.1","author":"Higgins","year":"2020"},{"issue":"(7414)","key":"2023072812242169700_zrad060-B21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"Br Med J"},{"key":"2023072812242169700_zrad060-B22","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2019"},{"key":"2023072812242169700_zrad060-B23","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-21416-0_1","volume-title":"An Introduction to Meta-Analysis in R","author":"Schwarzer","year":"2015"},{"key":"2023072812242169700_zrad060-B24","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"key":"2023072812242169700_zrad060-B25","volume-title":"Doing Meta-Analysis in R: A Hands-on Guide","author":"Harrer","year":"2019"},{"key":"2023072812242169700_zrad060-B26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s002689900420","article-title":"Long-term results of polyglactin mesh for the prevention of incisional hernias in obese patients","volume":"22","author":"Pans","year":"1998","journal-title":"World J Surg"},{"key":"2023072812242169700_zrad060-B27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s10029-003-0124-2","article-title":"Primary closure of laparotomies with high risk of incisional hernia using prosthetic material: analysis of usefulness","volume":"7","author":"Guti\u00e9rrez de la Pe\u00f1a","year":"2003","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B28","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/bjs.5512","article-title":"Randomized clinical trial of postoperative hernia prophylaxis in open bariatric surgery","volume":"93","author":"Strzelczyk","year":"2006","journal-title":"Br J Surg"},{"key":"2023072812242169700_zrad060-B29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10029-009-0484-3","article-title":"Prophylactic prosthetic reinforcement of midline abdominal incisions in high-risk patients","volume":"13","author":"El-Khadrawy","year":"2009","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B30","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/bjs.7137","article-title":"Randomized clinical trial of mesh versus sutured wound closure after open abdominal aortic aneurysm surgery","volume":"97","author":"Bevis","year":"2010","journal-title":"Br J Surg"},{"key":"2023072812242169700_zrad060-B31","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s11695-013-0915-1","article-title":"Prophylactic preperitoneal mesh placement in open bariatric surgery: a guard against incisional hernia development","volume":"23","author":"Abo-Ryia","year":"2013","journal-title":"Obes Surg"},{"key":"2023072812242169700_zrad060-B32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10029-014-1262-4","article-title":"A comparative study of sutured versus bovine pericardium mesh abdominal closure after open abdominal aortic aneurysm repair","volume":"19","author":"Bali","year":"2015","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B33","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.surg.2014.06.022","article-title":"A prospective, randomized, multicenter trial of surgisis gold, a biologic prosthetic, as a sublay reinforcement of the fascial closure after open bariatric surgery","volume":"156","author":"Sarr","year":"2014","journal-title":"Surgery"},{"key":"2023072812242169700_zrad060-B34","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/SLA.0000000000001116","article-title":"Randomized controlled trial of the use of a large-pore polypropylene mesh to prevent incisional hernia in colorectal surgery","volume":"261","author":"Garc\u00eda-Ure\u00f1a","year":"2015","journal-title":"Ann Surg"},{"key":"2023072812242169700_zrad060-B35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/SLA.0000000000001369","article-title":"Prevention of incisional hernias by prophylactic mesh-augmented reinforcement of midline laparotomies for abdominal aortic aneurysm treatment: a randomized controlled trial","volume":"263","author":"Muysoms","year":"2016","journal-title":"Ann Surg"},{"key":"2023072812242169700_zrad060-B36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0140-6736(17)31332-6","article-title":"Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement versus primary suture only in midline laparotomies (PRIMA): 2-year follow-up of a multicentre, double-blind, randomised controlled trial","volume":"390","author":"Jairam","year":"2017","journal-title":"Lancet"},{"key":"2023072812242169700_zrad060-B37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jamcollsurg.2019.09.010","article-title":"Prevention of fascial dehiscence with onlay prophylactic mesh in emergency laparotomy: a randomized clinical trial","volume":"230","author":"Lima","year":"2020","journal-title":"J Am Coll Surg"},{"key":"2023072812242169700_zrad060-B38","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00268-017-4363-2","article-title":"Prophylactic intraperitoneal onlay mesh reinforcement reduces the risk of incisional hernia, two-year results of a randomized clinical trial","volume":"42","author":"Brosi","year":"2018","journal-title":"World J Surg"},{"key":"2023072812242169700_zrad060-B39","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00268-019-04964-6","article-title":"Prophylactic intraperitoneal onlay mesh following midline laparotomy\u2013long-term results of a randomized controlled trial","volume":"43","author":"Glauser","year":"2019","journal-title":"World J Surg"},{"key":"2023072812242169700_zrad060-B40","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s00268-014-2510-6","article-title":"Prevention of incisional hernia in midline laparotomy with an onlay mesh: a randomized clinical trial","volume":"38","author":"Caro-Tarrago","year":"2014","journal-title":"World J Surg"},{"key":"2023072812242169700_zrad060-B41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10029-019-01891-2","article-title":"Long-term results of a prospective randomized trial of midline laparotomy closure with onlay mesh","volume":"23","author":"Caro-Tarrago","year":"2019","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B42","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/bjs\/znab068","article-title":"Prophylactic sublay non-absorbable mesh positioning following midline laparotomy in a clean-contaminated field: randomized clinical trial (PROMETHEUS)","volume":"108","author":"Pizza","year":"2021","journal-title":"Br J Surg"},{"key":"2023072812242169700_zrad060-B43","first-page":"265","article-title":"Use of an absorbable polyglactin mesh for the prevention of incisional hernias","volume":"95","author":"Pans","year":"1995","journal-title":"Acta Chir Belg"},{"key":"2023072812242169700_zrad060-B44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000355956","article-title":"Meta-analysis of primary mesh augmentation as prophylactic measure to prevent incisional hernia","volume":"30","author":"Timmermans","year":"2013","journal-title":"Dig Surg"},{"key":"2023072812242169700_zrad060-B45","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.amjsurg.2016.06.004","article-title":"Prophylactic mesh placement for prevention of incisional hernia following open bariatric surgery: a systematic review and meta-analysis","volume":"212","author":"Dasari","year":"2016","journal-title":"Am J Surg"},{"key":"2023072812242169700_zrad060-B46","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.surg.2016.09.036","article-title":"Does prophylactic mesh placement in elective, midline laparotomy reduce the incidence of incisional hernia? A systematic review and meta-analysis","volume":"161","author":"Borab","year":"2017","journal-title":"Surgery"},{"key":"2023072812242169700_zrad060-B47","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejvs.2018.03.021","article-title":"Prophylactic mesh reinforcement versus sutured closure to prevent incisional hernias after open abdominal aortic aneurysm repair via midline laparotomy: a systematic review and meta-analysis","volume":"56","author":"Indrakusuma","year":"2018","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2023072812242169700_zrad060-B48","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10029-019-02060-1","article-title":"Is there a role for prophylactic mesh in abdominal wall closure after emergency laparotomy? A systematic review and meta-analysis","volume":"24","author":"Burns","year":"2020","journal-title":"Hernia"},{"key":"2023072812242169700_zrad060-B49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/bjs5.50261","article-title":"Prevention of incisional hernia after midline laparotomy with prophylactic mesh reinforcement: a meta-analysis and trial sequential analysis","volume":"4","author":"Jairam","year":"2020","journal-title":"BJS Open"},{"key":"2023072812242169700_zrad060-B50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijsu.2020.08.059","article-title":"Mesh position for hernia prophylaxis after midline laparotomy: a systematic review and network meta-analysis of randomized clinical trials","volume":"83","author":"Tansawet","year":"2020","journal-title":"Int J Surg"},{"key":"2023072812242169700_zrad060-B51","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13063-022-06103-4","article-title":"PROPHYlactic implantation of BIOlogic mesh in peritonitis (PROPHYBIOM): a prospective multicentric randomized controlled trial","volume":"23","author":"Coccolini","year":"2022","journal-title":"Trials"}],"container-title":["BJS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/7\/4\/zrad060\/50985760\/zrad060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/7\/4\/zrad060\/50985760\/zrad060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T13:08:39Z","timestamp":1690549719000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjsopen\/article\/doi\/10.1093\/bjsopen\/zrad060\/7233018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7,10]]}},"URL":"https:\/\/doi.org\/10.1093\/bjsopen\/zrad060","relation":{},"ISSN":["2474-9842"],"issn-type":[{"value":"2474-9842","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,7,10]]},"article-number":"zrad060"}}