{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:23:53Z","timestamp":1788121433304,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Colorectal Research Summit Grant 2015"},{"name":"Korean Society of Coloproctology"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South Korean government"},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["2021R1A5A2021614"],"award-info":[{"award-number":["2021R1A5A2021614"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Evidence is lacking regarding the earliest timing of initiating adjuvant chemotherapy to maximize its efficacy safely. A trial was designed and conducted to evaluate the safety and oncological efficacy of early adjuvant chemotherapy compared with conventional adjuvant chemotherapy. The short-term outcomes are reported here.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A multicentre, randomized (1 : 1), open-label, phase III trial was conducted comparing early adjuvant chemotherapy with conventional adjuvant chemotherapy in patients with stage III colon cancer. Patients who underwent radical surgery who had stage III colon cancer confirmed by histopathological assessment were screened and randomized into the early adjuvant chemotherapy arm or the conventional adjuvant chemotherapy arm. The primary endpoint was 3-year disease-free survival. The adjuvant chemotherapy with FOLFOX was delivered between postoperative day 10 and 14 in the early adjuvant chemotherapy arm, and between postoperative day 24 and 28 in the conventional adjuvant chemotherapy arm. Toxicity and quality of life were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between 9 September 2011 and 6 March 2020, 443 patients consented to randomization at eight sites. The intention-to-treat population included 423 patients (209 in the early adjuvant chemotherapy arm and 214 in the conventional adjuvant chemotherapy arm), and the safety population included 380 patients (192 in the early adjuvant chemotherapy arm and 188 in the conventional adjuvant chemotherapy arm). There was no statistically significant difference in overall toxicity (28.1 per cent in the early adjuvant chemotherapy arm and 28.2 per cent in the conventional adjuvant chemotherapy arm, P = 0.244), surgical complications, and quality of life between the two arms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adjuvant chemotherapy can be safely initiated 2 weeks after surgery with toxicity and quality of life comparable to conventional adjuvant chemotherapy for stage III colon cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrad064","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T06:07:41Z","timestamp":1689228461000},"source":"Crossref","is-referenced-by-count":5,"title":["Short-term outcomes of Early <i>versus<\/i> conventional adjuvant chemotherapy in stage III colon cancer: randomized clinical trial"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-9000","authenticated-orcid":false,"given":"Kyung Ha","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine , Daejeon , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yeun","family":"Park","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Centre, Kyungpook National University Medical Centre, School of Medicine, Kyungpook National University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-7757","authenticated-orcid":false,"given":"Seung Ho","family":"Song","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Centre, Kyungpook National University Medical Centre, School of Medicine, Kyungpook National University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Centre, Kyungpook National University Medical Centre, School of Medicine, Kyungpook National University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Gwang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Haematology, Kyungpook National University Medical Centre, Kyungpook National University School of Medicine , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Woog","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Haematology, Kyungpook National University Medical Centre, Kyungpook National University School of Medicine , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9074-5214","authenticated-orcid":false,"given":"In Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-2774","authenticated-orcid":false,"given":"Yoon Suk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-329X","authenticated-orcid":false,"given":"So Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectum, Department of Surgery, College of Medicine, Yeungnam University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Kyu","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Dongsan Medical Centre, Keimyung University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Uk","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Dongsan Medical Centre, Keimyung University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyung Mo","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Surgery, Busan National University , Busan , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Beom","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Surgery, Busan Paik Hospital, Inje University , Busan , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-4610","authenticated-orcid":false,"given":"Gyu-Seog","family":"Choi","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Centre, Kyungpook National University Medical Centre, School of Medicine, Kyungpook National University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Centre, Kyungpook National University Medical Centre, School of Medicine, Kyungpook National University , Daegu , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine , Daejeon , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,13]]},"container-title":["BJS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/7\/4\/zrad064\/51315048\/zrad064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/7\/4\/zrad064\/51315048\/zrad064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T10:57:55Z","timestamp":1693479475000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjsopen\/article\/doi\/10.1093\/bjsopen\/zrad064\/7223517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7,10]]}},"URL":"https:\/\/doi.org\/10.1093\/bjsopen\/zrad064","relation":{},"ISSN":["2474-9842"],"issn-type":[{"value":"2474-9842","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,7,10]]},"article-number":"zrad064"}}