{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:35:09Z","timestamp":1790354109282,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The role of duct excision surgery is not clearly defined in patients with pathological nipple discharge without other clinical and radiological abnormalities. The primary aim of this systematic review was to determine the malignancy rate in patients with pathological nipple discharge after duct excision surgery (microdochectomy\/major duct excision). The secondary aims were to determine the recurrence rate of pathological nipple discharge after surgery and to assess breast cancer development after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MEDLINE and Embase were searched from inception to March 2023, using search terms related to \u2018nipple discharge\u2019, \u2018nipple fluid\u2019, \u2018microdochectomy\u2019, \u2018duct excision\u2019, and \u2018minimally invasive surgical procedure\u2019. Studies reporting data about women who underwent duct excision surgery for pathological nipple discharge without clinical and radiological suspicion of breast cancer, as well as reporting data on women diagnosed with breast cancer after duct excision surgery, were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 318 titles were identified, of which nine publications were included in the analysis. This resulted in 1108 patients with pathological nipple discharge who underwent a duct excision. The weighted mean rate of malignancy after duct excision surgery was 8.1 per cent (ranging from 2.3 to 13.5 per cent). Three studies described the recurrence rate of pathological nipple discharge (ranging from 0 to 12 per cent) and two studies reported breast cancer development in the follow-up in a total of three patients (less than 1 per cent).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The malignancy rate after duct excision surgery for pathological nipple discharge was low in patients with pathological nipple discharge without radiological and clinical abnormalities and approximately 9 of 10 patients undergo surgery for a benign cause. Improvement of the diagnostic and therapeutic workup is needed to prevent patients from undergoing (unnecessary) exploratory surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrad066","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T14:32:58Z","timestamp":1689604378000},"source":"Crossref","is-referenced-by-count":7,"title":["Role of duct excision surgery in the treatment of pathological nipple discharge and detection of breast carcinoma: systematic review"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1726-3160","authenticated-orcid":false,"given":"Seher","family":"Makineli","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem M","family":"van Wijnbergen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno R","family":"Vriens","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"van Diest","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen J","family":"Witkamp","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"2023071714323736700_zrad066-B1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.surg.2015.05.020","article-title":"Frequency of diagnosis of cancer or high-risk lesion at operation for pathologic nipple discharge","volume":"158","author":"Dupont","year":"2015","journal-title":"Surgery"},{"key":"2023071714323736700_zrad066-B2","first-page":"471","article-title":"Management of nipple discharge","volume":"178","author":"Gulay","year":"1994","journal-title":"J Am Coll Surg"},{"key":"2023071714323736700_zrad066-B3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00007611-198801000-00005","article-title":"Nipple discharge: surgical significance","volume":"81","author":"Leis","year":"1988","journal-title":"South Med J"},{"key":"2023071714323736700_zrad066-B4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ogc.2013.05.004","article-title":"Benign breast disorders","volume":"40","author":"Onstad","year":"2013","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2023071714323736700_zrad066-B5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00423-004-0515-6","article-title":"Management strategies for patients with nipple discharge","volume":"390","author":"Goksel","year":"2005","journal-title":"Langenbecks Arch Surg"},{"key":"2023071714323736700_zrad066-B6","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1177\/000313480006601011","article-title":"A simple approach to nipple discharge","volume":"66","author":"King","year":"2000","journal-title":"Am Surg"},{"key":"2023071714323736700_zrad066-B7","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s10549-010-0815-1","article-title":"Nipple discharge: is its significance as a risk factor for breast cancer fully understood? 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