{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:49:41Z","timestamp":1787993381009,"version":"build-2784847793"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abbott Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The fate of patients with chronic limb-threatening ischaemia undergoing revascularization or a primary amputation is unclear. The aim of this study was to assess the postoperative outcomes and post-procedural healthcare resource use\/costs over 1 year after revascularization or a primary amputation for chronic limb-threatening ischaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The UK Kent Integrated Dataset, which links primary, community, and secondary care for 1.6 million people, was interrogated. All patients with a new diagnosis of chronic limb-threatening ischaemia undergoing revascularization or a major amputation between January 2016 and January 2019 (3 years) were identified. Postoperative events across all healthcare settings and post-procedure healthcare resource use were analysed over 1 year (until the end of 2019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 4252 patients with a new diagnosis of chronic limb-threatening ischaemia were identified (65 per cent were male and the mean age was 73 years) between January 2016 and January 2019, of whom 579 (14 per cent) underwent an intervention (studied population); 296 (7 per cent) had an angioplasty, 75 (2 per cent) had bypass surgery, 141 (3 per cent) had a primary major lower limb amputation, 11 had a thrombo-embolectomy (0.3 per cent), and 56 had an endarterectomy (1.3 per cent). Readmissions (median of 2) were similar amongst different procedures within 1 year; bypass surgery was associated with more hospital appointments (median of 4 versus 2; P = 0.002). Patients undergoing a primary amputation had the highest number of cardiovascular events and 1-year mortality. In a linear regression model, index procedure type and Charlson co-morbidity index score were not predictors of appointments in primary\/secondary care, community care visits, or readmissions after discharge. There were no statistically significant differences regarding post-procedural healthcare costs between procedures over 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Revascularization is not associated with more hospital, primary\/community care appointments or increased post-procedural healthcare costs over 1 year when compared with primary amputation, in people with chronic limb-threatening ischaemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrad112","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T03:23:31Z","timestamp":1699413811000},"source":"Crossref","is-referenced-by-count":4,"title":["Outcomes and use of healthcare resources after an intervention for chronic limb-threatening ischaemia"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-094X","authenticated-orcid":false,"given":"Athanasios","family":"Saratzis","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester , Leicester , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Musto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester , Leicester , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"National Health Service Health Economics Unit, NHS Midlands and Lancashire Commissioning Support Unit , Stoke on Trent , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Health Service Health Economics Unit, NHS Midlands and Lancashire Commissioning Support Unit , Stoke on Trent , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Bojko","sequence":"additional","affiliation":[{"name":"National Health Service Health Economics Unit, NHS Midlands and Lancashire Commissioning Support Unit , Stoke on Trent , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lillington","sequence":"additional","affiliation":[{"name":"National Health Service Health Economics Unit, NHS Midlands and Lancashire Commissioning Support Unit , Stoke on Trent , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Anyadi","sequence":"additional","affiliation":[{"name":"National Health Service Health Economics Unit, NHS Midlands and Lancashire Commissioning Support Unit , Stoke on Trent , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Zayed","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Sciences, King\u2019s College , London , UK"},{"name":"Department of Vascular Surgery, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"2023122907214682300_zrad112-B1","doi-asserted-by":"crossref","first-page":"j5842","DOI":"10.1136\/bmj.j5842","article-title":"Peripheral artery disease","volume":"360","author":"Morley","year":"2018","journal-title":"BMJ"},{"key":"2023122907214682300_zrad112-B2","author":"National Institute for Health and Care Excellence","year":"2020"},{"key":"2023122907214682300_zrad112-B3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-018184","article-title":"Time trends in peripheral artery disease incidence, prevalence and secondary preventive therapy: a cohort study in The Health Improvement Network in the UK","volume":"8","author":"Cea-Soriano","year":"2018","journal-title":"BMJ 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