{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:47:23Z","timestamp":1785332843311,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018571","name":"Specific Research Project of Guangxi for Research Bases and Talents","doi-asserted-by":"publisher","award":["AD22035057"],"award-info":[{"award-number":["AD22035057"]}],"id":[{"id":"10.13039\/501100018571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060510"],"award-info":[{"award-number":["82060510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260569"],"award-info":[{"award-number":["82260569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor"},{"DOI":"10.13039\/100009122","name":"Ministry of Education","doi-asserted-by":"publisher","award":["GKE-ZZ202217"],"award-info":[{"award-number":["GKE-ZZ202217"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009122","name":"Ministry of Education","doi-asserted-by":"publisher","award":["GKE-ZZ202311"],"award-info":[{"award-number":["GKE-ZZ202311"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The prognostic significance of the aspartate aminotransferase\/alanine aminotransferase (AST\/ALT) ratio in hepatocellular carcinoma remains uncertain. The aim of the current study was to evaluate the association between the AST\/ALT ratio and prognosis in patients with hepatocellular carcinoma after hepatectomy, and to explore the role of underlying liver diseases as mediators.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study included patients with hepatocellular carcinoma who underwent hepatectomy between January 2014 and January 2018 at two Chinese hospitals. The maximally selected rank statistic and g-computation approach were used to quantify and visualize the association between the AST\/ALT ratio and overall survival or recurrence-free survival. The role of mediators (chronic hepatitis B, hepatic steatosis and liver cirrhosis) was analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 1519 patients (mean(s.d.) age at baseline, 50.5(11.3) years), 1309 (86.2%) were male. During a median follow-up of 46.0 months, 514 (33.8%) patients died and 358 (23.6%) patients experienced recurrence. The optimal cut-off value for the AST\/ALT ratio was 1.4, and the AST\/ALT ratio greater than or equal to 1.4 was independently associated with a 39.0% increased risk of death and a 30.0% increased risk of recurrence (overall survival: hazard ratio (HR), 1.39; 95% c.i. 1.15 to 1.68; recurrence-free survival: HR, 1.30; 95% c.i. 1.12 to 1.52) after adjusting for confounders. Chronic hepatitis B significantly mediated the association of the ratio of AST\/ALT with both overall survival and recurrence-free survival (20.3% for overall survival; 20.1% for recurrence-free survival).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The AST\/ALT ratio greater than or equal to 1.4 was associated with shorter overall survival and recurrence-free survival in patients with hepatocellular carcinoma after hepatectomy, and chronic hepatitis B may play a role in their association.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrad155","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T22:26:05Z","timestamp":1705703165000},"source":"Crossref","is-referenced-by-count":12,"title":["Prognostic value of aspartate aminotransferase\/alanine aminotransferase ratio in hepatocellular carcinoma after hepatectomy"],"prefix":"10.1093","volume":"8","author":[{"given":"Rong-Rui","family":"Huo","sequence":"first","affiliation":[{"name":"Hepatobiliary Surgery Department, Guangxi Medical University Cancer Hospital , Nanning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Xin","family":"Pan","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery Department, Guangxi Medical University Cancer Hospital , Nanning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Sheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery Department, The First People\u2019s Hospital of Qinzhou , Qinzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Mei","family":"Liang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery Department, Guangxi Medical University Cancer Hospital , Nanning , 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