{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:27Z","timestamp":1753875987534,"version":"3.41.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270632","82260411"],"award-info":[{"award-number":["82270632","82260411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia Fund Special Project for Echinococcosis","award":["SKL-HIDCS-2020-BC2"],"award-info":[{"award-number":["SKL-HIDCS-2020-BC2"]}]},{"name":"Shu-Lan Excellent Project-Support Program for Overseas Study of Young Talents in Organ Transplantation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Posthepatectomy liver failure remains a potentially life-threatening complication after hepatectomy. Soluble suppression of tumourigenicity 2 is an injury-related biomarker. The aim of the study was to assess soluble suppression of tumourigenicity 2 elevation after hepatectomy and whether it can predict posthepatectomy liver failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a single-centre retrospective study including all patients who underwent a liver resection between 2015 and 2019. Plasma concentrations of soluble suppression of tumourigenicity 2 were measured before surgery and at postoperative days 1, 2, 5 and 7. Posthepatectomy liver failure was defined according to the International Study Group of Liver Surgery and the morbidity rate was graded according to the Clavien\u2013Dindo classification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 173 patients were included (75 underwent major and 98 minor resection); plasma levels of soluble suppression of tumourigenicity 2 increased from 43.42 (range 18.69\u2013119.96) pg\/ml to 2622.23 (range 1354.18\u20134178.27) pg\/ml on postoperative day 1 (P &amp;lt; 0.001). Postoperative day 1 soluble suppression of tumourigenicity 2 concentration accurately predicted posthepatectomy liver failure \u2265 grade B (area under curve = 0.916, P &amp;lt; 0.001) and its outstanding performance was not affected by underlying disease, liver pathological status and extent of resection. The cut-off value, sensitivity, specificity, positive predictive value and negative predictive value of postoperative day 1 soluble suppression of tumourigenicity 2 in predicting posthepatectomy liver failure \u2265 grade B were 3700, 92%, 85%, 64% and 97% respectively. Soluble suppression of tumourigenicity 2high patients more frequently experienced posthepatectomy liver failure \u2265 grade B (64.3% (n = 36) versus 2.6% (n = 3)) and Clavien\u2013Dindo IIIa higher morbidity rate (23.2% (n = 13) versus 5.1% (n = 6)) compared with soluble suppression of tumourigenicity 2low patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Soluble suppression of tumourigenicity 2 may be a reliable predictor of posthepatectomy liver failure \u2265 grade B as early as postoperative day 1 for patients undergoing liver resection. Its role in controlling hepatic injury\/regeneration needs further investigation.<\/jats:p>\n                  <jats:p>Registration number: ChiCTR-OOC-15007210 (www.chictr.org.cn\/).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrae043","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T17:44:01Z","timestamp":1719510241000},"source":"Crossref","is-referenced-by-count":0,"title":["Soluble suppression of tumourigenicity 2 as a predictor of postoperative hepatic failure"],"prefix":"10.1093","volume":"8","author":[{"given":"Jing","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadike","family":"Apaer","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiapukaiti","family":"Fulati","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique A","family":"Vuitton","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Prevention and Treatment of Human Echinococcosis and French National Centre for Echinococcosis, University Bourgogne Franche-Comt\u00e9 and National Reference Centre for Echinococcosis\/EurEchino Network , Besan\u00e7on , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangduosi","family":"Payiziwula","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuerzhatijiang","family":"Anweier","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kahaer","family":"Tuerxun","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The First People\u2019s Hospital of Kashi Perfecture , Kashi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuerganaili","family":"Aji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingmei","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-1472","authenticated-orcid":false,"given":"Tuerhongjiang","family":"Tuxun","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"},{"name":"State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University , Urumqi , China"},{"name":"State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,27]]},"container-title":["BJS 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