{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:58:58Z","timestamp":1792180738696,"version":"4.4.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ligation of intersphincteric fistula tract is a surgical technique designed to treat trans-sphincteric anal fistulas aiming to preserve sphincter integrity. Recent studies suggest its efficacy in short-term fistula healing with limited impact on continence. However, comprehensive prospective data on long-term outcomes, including recurrence and bowel continence, are limited. The present study aims to report on the long-term functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent the ligation of intersphincteric fistula tract procedure for trans-sphincteric cryptoglandular anal fistulas between July 2012 and October 2018 at two Dutch referral centres were retrospectively reviewed. The primary outcome of interest was the long-term bowel continence after the ligation of intersphincteric fistula tract procedure, using the faecal incontinence severity index. Short-term data (collected in 2018) and long-term data (collected in 2023) on bowel continence, healing rates and recurrences were obtained through electronic records and Rockwood questionnaires. Sankey diagrams were used to visually represent individual variations in continence status (preoperative versus follow-up).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 110 patients included (50% female, median follow-up 92 months), 101 patients (92%) were treated with previous surgeries (median 2, range 0\u20136) and 80% had previous seton drainage. Preligation of intersphincteric fistula tract, 16% of the patients reported incontinence (mean(s.d.) faecal incontinence severity index: 2.4(7.5), increasing to 18% after ligation of intersphincteric fistula tract at short-term follow-up, including 11% newly induced cases. Long-term follow-up collected using Rockwood questionnaires (63% response rate) in 69 patients uncovered a 74% incontinency rate (mean(s.d.) faecal incontinence severity index: 9.22(9.5). In those patients without subsequent surgery 49% (17 of 35) reported incontinence at long-term follow-up. Primary fistula healing after ligation of intersphincteric fistula tract was 28%. Preoperative seton drainage significantly improved healing rates (33% versus 9%). Notably, 43% (34 of 79) of unhealed fistulas transitioned into intersphincteric tracts; in these patients, 19 were treated with subsequent fistulotomy achieving cure in 18 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ligation of intersphincteric fistula tract healing rates fell below recent literature standards. Although the immediate impact on postoperative continence appears minimal, long-term incontinence rates are concerning. In recognizing the deterioration of individual continence, we advocate for a patient-centered approach and urge fellow researchers and clinicians to collect comprehensive prospective continence data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrae055","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T20:56:44Z","timestamp":1713301004000},"source":"Crossref","is-referenced-by-count":11,"title":["Ligation of intersphincteric fistula tract (LIFT) for trans-sphincteric cryptoglandular anal fistula: long-term impact on faecal continence"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-3997","authenticated-orcid":false,"given":"Justin Y","family":"van Oostendorp","sequence":"first","affiliation":[{"name":"Department of Surgery, Proctos Kliniek , Bilthoven , The Netherlands"},{"name":"Department of Surgery, Amsterdam University Medical Centers , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-2174","authenticated-orcid":false,"given":"Carolien","family":"Verkade","sequence":"additional","affiliation":[{"name":"Department of Surgery, Elisabeth-TweeSteden Hospital , Tilburg , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-0574","authenticated-orcid":false,"given":"Ingrid J M","family":"Han-Geurts","sequence":"additional","affiliation":[{"name":"Department of Surgery, Proctos Kliniek , Bilthoven , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-9591","authenticated-orcid":false,"given":"Grietje J H","family":"van der Mijnsbrugge","sequence":"additional","affiliation":[{"name":"Department of Surgery, Proctos Kliniek , Bilthoven , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-0219","authenticated-orcid":false,"given":"Dareczka K","family":"Wasowicz-Kemps","sequence":"additional","affiliation":[{"name":"Department of Surgery, Elisabeth-TweeSteden Hospital , Tilburg , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0393-9350","authenticated-orcid":false,"given":"David D E","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Elisabeth-TweeSteden Hospital , Tilburg , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"2024062805131091000_zrae055-B1","first-page":"e28289","article-title":"A comparison of different surgical treatments for complex anal fistula: a systematic review","volume":"14","author":"Zahra","year":"2022","journal-title":"Cureus"},{"key":"2024062805131091000_zrae055-B2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/codi.13330","article-title":"Adoption and success rates of perineal procedures for fistula-in-ano: a systematic review","volume":"18","author":"Kontovounisios","year":"2016","journal-title":"Colorectal Dis"},{"key":"2024062805131091000_zrae055-B3","first-page":"581","article-title":"Total anal sphincter saving technique for fistula-in-ano; 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