{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:18:11Z","timestamp":1784269091525,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIHR Patient Safety Translational Research Centre"},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"Imperial NIHR Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030827","name":"NHS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Inflammatory bowel disease increases the risk of colorectal neoplasia. A particular problem arises in patients who have undergone subtotal colectomy leaving a rectal remnant. The risk of future rectal cancer must be accurately estimated and weighed against the risks of further surgery or surveillance. The aim of this study was to estimate the 10-year cumulative incidence of rectal cancer in such patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A nationwide study using England\u2019s hospital administrative data was performed. A cohort of patients undergoing subtotal colectomy between April 2002 and March 2014 was identified. A competing risks survival analysis was performed to calculate the cumulative incidence of rectal cancer. The effect of the COVID-19 pandemic on endoscopic surveillance was investigated using time-trend analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 8120 patients were included and 61 patients (0.8%) were diagnosed with cancer. The cumulative incidence of rectal cancer was 0.26% (95% c.i. 0.17% to 0.39%), 0.49% (95% c.i. 0.36% to 0.68%), and 0.77% (95% c.i. 0.57% to 1.02%) at 5, 10, and 15 years respectively. A previous diagnosis of colonic dysplasia (HR 3.34, 95% c.i. 1.01 to 10.97; P = 0.047), primary sclerosing cholangitis (HR 5.42, 95% c.i. 1.34 to 21.85; P = 0.018), and elective colectomy (HR 1.83, 95% c.i. 1.11 to 3.02; P = 0.018) was associated with an increased incidence of rectal cancer. Regarding endoscopic surveillance, there was a 43% decline in endoscopic procedures performed in 2020 (333 procedures) compared with 2019 (585 procedures).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The incidence of rectal cancer after subtotal colectomy is low. Asymptomatic patients without evidence of rectal dysplasia should be carefully counselled on the possible benefits and risks of prophylactic proctectomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrae074","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T09:30:34Z","timestamp":1728984634000},"source":"Crossref","is-referenced-by-count":2,"title":["Incidence of rectal cancer after colectomy for inflammatory bowel disease: nationwide study"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-8434","authenticated-orcid":false,"given":"Mohammed","family":"Deputy","sequence":"first","affiliation":[{"name":"Surgical Epidemiology, Trials and Outcome Centre, St Mark\u2019s Hospital and Academic Institute , Harrow ,","place":["UK"]},{"name":"Department of Surgery and Cancer, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-7641","authenticated-orcid":false,"given":"Guy","family":"Worley","sequence":"additional","affiliation":[{"name":"Surgical Epidemiology, Trials and Outcome Centre, St Mark\u2019s Hospital and Academic Institute , Harrow ,","place":["UK"]},{"name":"Department of Surgery and Cancer, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-6332","authenticated-orcid":false,"given":"Elaine M","family":"Burns","sequence":"additional","affiliation":[{"name":"Surgical Epidemiology, Trials and Outcome Centre, St Mark\u2019s Hospital and Academic Institute , Harrow ,","place":["UK"]},{"name":"Department of Surgery and Cancer, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-2011","authenticated-orcid":false,"given":"Alex","family":"Bottle","sequence":"additional","affiliation":[{"name":"School of Public Health, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Aylin","sequence":"additional","affiliation":[{"name":"School of Public Health, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailsa","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London , London ,","place":["UK"]},{"name":"Department of Gastroenterology, St Mark\u2019s Hospital and Academic Institute , Harrow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Faiz","sequence":"additional","affiliation":[{"name":"Surgical Epidemiology, Trials and Outcome Centre, St Mark\u2019s Hospital and Academic Institute , Harrow ,","place":["UK"]},{"name":"Department of Surgery and Cancer, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"2024102920541922600_zrae074-B1","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1056\/NEJMra1403718","article-title":"Cancers complicating inflammatory bowel disease","volume":"372","author":"Beaugerie","year":"2015","journal-title":"N Engl J Med"},{"key":"2024102920541922600_zrae074-B2","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/codi.15460","article-title":"Management of inflammatory bowel disease associated colonic dysplasia: factors predictive of patient choice and satisfaction","volume":"23","author":"Kabir","year":"2021","journal-title":"Colorectal 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