{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:40:31Z","timestamp":1791258031674,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ricerca corrente funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Familial adenomatous polyposis is a cancer-predisposing syndrome caused by germline pathogenic variants of the adenomatous polyposis coli gene, leading to numerous colorectal polyps and a high risk of colorectal cancer. Desmoid tumours have become significant in the management of familial adenomatous polyposis after a colectomy, yet the exact incidence remains undetermined due to a lack of dedicated surveillance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study accessed data from the prospectively maintained Hereditary Digestive Tumours Registry from 2000 to 2023. Desmoid-free survival was analysed using Cox regression and Kaplan\u2013Meier curves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 202 patients with familial adenomatous polyposis who underwent colorectal surgery were enrolled. Of the patients, 21 (10.4%) developed intra-abdominal desmoid tumours after surgery. Desmoid tumours were associated with surgical procedure, histology of cancer at the time of surgery, and family history of intra-abdominal desmoid tumours. The overall desmoid-free survival probability at a median follow-up of 84\u2005months was 90%. Histology of cancer at the time of surgery (HR 0.25 (95% c.i. 0.10 to 0.59)), family history of intra-abdominal desmoid tumours (HR 2.92 (95% c.i. 1.22 to 6.97)), an open approach compared with a laparoscopic approach (HR 2.43 (95% c.i. 1.03 to 5.73)), and a proctocolectomy compared with a rectal-sparing total colectomy (HR 3.01 (95% c.i. 1.28 to 7.10)) emerged as significant prognostic factors affecting desmoid-free survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A minimally invasive rectal-sparing total colectomy appears protective against the development of desmoid tumours. Early surgery does not seem to increase desmoid tumour risk. A dedicated surveillance regimen for desmoid tumours in patients with familial adenomatous polyposis is needed to improve outcomes and quality of life.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrae148","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T08:39:33Z","timestamp":1735547973000},"source":"Crossref","is-referenced-by-count":2,"title":["Risk factors and protective measures for desmoid tumours in familial adenomatous polyposis: retrospective cohort study"],"prefix":"10.1093","volume":"9","author":[{"given":"Emanuele","family":"Rausa","sequence":"first","affiliation":[{"name":"Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]},{"name":"Colorectal Surgery Division, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Duroni","sequence":"additional","affiliation":[{"name":"Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7058-5011","authenticated-orcid":false,"given":"Davide","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]},{"name":"Colorectal Surgery Division, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]},{"name":"General Surgery Residency Programme, Universit\u00e0 degli Studi di Milano , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Signoroni","sequence":"additional","affiliation":[{"name":"Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara M","family":"Ciniselli","sequence":"additional","affiliation":[{"name":"Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lauricella","sequence":"additional","affiliation":[{"name":"Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]},{"name":"Colorectal Surgery Division, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clorinda","family":"Brignola","sequence":"additional","affiliation":[{"name":"Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T","family":"Ricci","sequence":"additional","affiliation":[{"name":"Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4703-3534","authenticated-orcid":false,"given":"Alessandro","family":"Gronchi","sequence":"additional","affiliation":[{"name":"Sarcoma Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-1281","authenticated-orcid":false,"given":"Paolo","family":"Verderio","sequence":"additional","affiliation":[{"name":"Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-5315","authenticated-orcid":false,"given":"Marco","family":"Vitellaro","sequence":"additional","affiliation":[{"name":"Unit of Hereditary Digestive Tract Tumours, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]},{"name":"Colorectal Surgery Division, Fondazione IRCCS Istituto Nazionale dei Tumouri , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,30]]},"container-title":["BJS 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