{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:26Z","timestamp":1787008526832,"version":"build-2736575974"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Navamindradhiraj University Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adverse events after endoscopic retrograde cholangiopancreatography (ERCP) are rare, and post-ERCP pancreatitis is a serious adverse event. This study aimed to determine the role of aggressive intravenous hydration with lactated Ringer\u2019s solution at a specific volume with 20% human albumin before ERCP in reducing the incidence of post-ERCP pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a single-centre randomized clinical trial. The participants were randomly assigned to two groups: those who received aggressive intravenous hydration with 20% human albumin and lactated Ringer's solution (intervention group), and those who received standard-volume intravenous hydration with lactated Ringer's solution (control group). The primary endpoint was post-ERCP pancreatitis. Participants and outcome assessors were blinded to treatment allocation. Comparison was performed using the chi-square, the Fisher\u2019s exact, the Student\u2019s t, or the Mann\u2013Whitney U tests, where appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 300 randomized participants, 149 and 144 participants from the intervention and control group were included in the analysis. There was no significant difference in the post-ERCP pancreatitis rate (n = 10; 6.7% versus n = 9; 6.3%, P = 0.873) between the intervention and control groups. High-risk procedures (that is pancreatic duct wiring, pancreatic duct injection, precut sphincterotomy, and balloon dilation of the ampulla) were significantly associated with post-ERCP pancreatitis compared with low-risk procedures (n = 15; 15% versus n = 4; 2.1%, P &amp;lt; 0.001). In the high-risk procedures population, the intervention and control groups had increased post-ERCP pancreatitis rates (P = 0.716). Two participants in each group developed pulmonary congestion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aggressive peri-ERCP intravenous hydration with lactated Ringer's solution combined with 50\u2005ml of 20% human albumin did not prevent post-ERCP pancreatitis. None of the subgroups presented with prophylactic effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Thai Clinical Trials Registry (TCTR20240405003)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrae149","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T23:20:05Z","timestamp":1732404005000},"source":"Crossref","is-referenced-by-count":5,"title":["High-volume lactated Ringer\u2019s solution with human albumin\n                    <i>versus<\/i>\n                    standard-volume infusion as a prophylactic treatment for post-endoscopic retrograde cholangiopancreatography pancreatitis: randomized clinical trial"],"prefix":"10.1093","volume":"9","author":[{"given":"Ekaphan","family":"Shatsnimitkul","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine Vajira Hospital, Navamindradhiraj University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issaree","family":"Laopeamthong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine Vajira Hospital, Navamindradhiraj University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-7970","authenticated-orcid":false,"given":"Amarit","family":"Tansawet","sequence":"additional","affiliation":[{"name":"Department of Research and Medical Innovation, Faculty of Medicine Vajira Hospital, Navamindradhiraj University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphakarn","family":"Techapongsatorn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine Vajira Hospital, Navamindradhiraj University , Bangkok 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