{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:11:41Z","timestamp":1778267501432,"version":"3.51.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004886","name":"Cancer Research Foundation in Northern Sweden","doi-asserted-by":"publisher","award":["AMP 19-978"],"award-info":[{"award-number":["AMP 19-978"]}],"id":[{"id":"10.13039\/501100004886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","award":["SLS-934594"],"award-info":[{"award-number":["SLS-934594"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["RV-762241"],"award-info":[{"award-number":["RV-762241"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Postoperative death measured 30 days after surgery is a conventional quality metric, whereas intervals up to 90 days are increasingly used, although data-driven time windows have scarcely been investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Swedish Colorectal Cancer Registry was used to identify all patients subjected resection for colorectal cancer between 2007 and 2020. All patients were followed up until 180 days after surgery. A join-point statistical hazard model was used to model a declining hazard to a transition point, followed by a stable death rate. This method was subsequently applied to describe postoperative deaths for the entire cohort and subgroups according to tumour location (colon and rectum).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 56 096 patients electively operated on for colorectal cancer during the study interval were included, with a 30-day and 90-day fatality of 805 (1.43%) and 1458 (2.60%) patients respectively. The derived postoperative fatality window, after which the death rate transitioned to a stable rate, was 23.8 (95% c.i. 21.5 to 28.2) days after surgery. There was no significant difference in the time window between rectal cancer (22.9 days; 95% c.i. 15.1 to 28.4) and colon cancer (27.3 days; 95% c.i. 21.4 to 31.8) patients (P = 0.455). However, postoperative fatality time windows were extended in patients aged at least 80 years and with American Society of Anesthesiologists\u2019 grade III or IV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The traditional postoperative time window of 30 days was confirmed to be an appropriate metric in elective colorectal cancer surgery when evaluated with a hazards-based statistical framework. Importantly, this time window is influenced by older age and advanced co-morbidity, which could prompt increased vigilance for these patient groups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrae153","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T11:53:46Z","timestamp":1737719626000},"source":"Crossref","is-referenced-by-count":1,"title":["Estimation of the postoperative fatality window in colorectal cancer surgery"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-6373","authenticated-orcid":false,"given":"Martin","family":"Ruteg\u00e5rd","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Intervention, Surgery, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]},{"name":"Wallenberg Centre for Molecular Medicine, Ume\u00e5 University , Ume\u00e5 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University , Ume\u00e5 ,","place":["Sweden"]},{"name":"Department of Statistics, Ume\u00e5 School of Business, Economics and Statistics, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"2025030423540658500_zrae153-B1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/bjs.8813","article-title":"Comparison of 30-day, 90-day and in-hospital postoperative mortality for eight different cancer types","volume":"99","author":"Damhuis","year":"2012","journal-title":"Br J Surg"},{"key":"2025030423540658500_zrae153-B2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/bjs5.50106","article-title":"Population-based cohort study of the impact on postoperative mortality of anastomotic leakage after anterior resection for rectal cancer","volume":"3","author":"Bostrom","year":"2019","journal-title":"BJS 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