{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:00Z","timestamp":1787068440422,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of surgical excision margin size on the survival of patients with cutaneous melanoma (CM) is controversial. The aim of this study was to assess the impact of excision margins on patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective population-based follow-up study analysed data from patients presenting with CM without extranodal disease. The linear distance of CM from the excision margin was assessed microscopically. Regarding overall and melanoma-specific survival estimates, Kaplan\u2013Meier analysis, the Cox proportional hazards model, and the subdistribution hazard ratio of the Fine\u2013Gray model were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 3262 patients, a total of 2698 (82.7%) with pathological (p) T1\u20132 and 564 (17.3%) with pT3\u20134 CM underwent wide local excision. Multivariable analyses, adjusting for melanoma incidence cohort, age, sex, anatomical site, ulceration, histotype, mitotic count, and tumour-infiltrating lymphocytes, demonstrated that, in pT1\u20132 CM, surgical excision &amp;gt; 1.1\u2005cm resulted in significant CM-specific survival benefit. In pT4 disease, a CM distance to the surgical margins of &amp;lt; 1.6\u2005cm significantly lowered CM-specific survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This population-based study conducted in real-world clinical practice found that the prognosis of patients with pT1\u20132 CM may benefit from excision margins &amp;gt; 1.1\u2005cm. In pT3\u20134 CM, margins &amp;lt; 1.6\u2005cm were significantly associated with lower CM-specific survival rates. These findings highlight the need for further prospective studies to evaluate the safety of surgical excision margins in managing primary CM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf042","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:22:00Z","timestamp":1740986520000},"source":"Crossref","is-referenced-by-count":4,"title":["Excision margins and prognosis in cutaneous melanoma: retrospective population-based cohort study"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-3807","authenticated-orcid":false,"given":"Alessandra","family":"Buja","sequence":"first","affiliation":[{"name":"Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2014DIMED, Surgical Pathology and Cytopathology, University of Padova , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-7930","authenticated-orcid":false,"given":"Chiara","family":"Trevisiol","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2014IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zanovello","sequence":"additional","affiliation":[{"name":"Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Dall\u2019Olmo","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2014IRCCS , Padua ,","place":["Italy"]},{"name":"Department of Surgery, Oncology, and Gastroenterology\u2014DISCOG, University of Padova , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Veneto Cancer Registry (RTV), Azienda Zero , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Vecchiato","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2014IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Del Fiore","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2014IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Paiola","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2014IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Riccardo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology, and Gastroenterology\u2014DISCOG, University of Padova , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mocellin","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2014IRCCS , Padua ,","place":["Italy"]},{"name":"Department of Surgery, Oncology, and Gastroenterology\u2014DISCOG, University of Padova , Padua 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