{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:34:09Z","timestamp":1790800449855,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Departament de Recerca i Universitats de la Generalitat de Catalunya i l\u2019AGAUR\u201d","award":["2021 SGR 00808"],"award-info":[{"award-number":["2021 SGR 00808"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Anastomotic leak and subsequent organ\/space surgical site infection (O\/S-SSI) after colorectal cancer surgery are associated with poor short-term outcomes; however, the evidence regarding long-term outcomes is inconclusive. This population-based retrospective cohort study aimed to evaluate the association between O\/S-SSI and both tumour recurrence and long-term survival after curative rectal cancer surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data was obtained for all adults who underwent curative oncological resection of the rectum in the periods 2011\u20132012 and 2015\u20132016 (n = 2208) in Spain. Multivariable analysis (Cox proportional hazards model) was used to evaluate the effects of clinical and pathological characteristics, as well as the occurrence of O\/S-SSI, on recurrence and survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all, 2208 adults underwent curative rectal cancer resection, 1464 of whom were male (66.3%); the median patient age was 69.1 years. O\/S-SSI occurred in 291 patients (13%). Independent predictors of recurrence included tumour stage III (hazard ratio (HR) 1.95, 95% confidence interval (c.i.) 1.06 to 3.58; P = 0.032), a positive resection margin (HR 4.03, 95% c.i. 2.58 to 6.29; P &amp;lt; 0.001), and poor quality mesorectal excision (HR 1.81, 95% c.i. 1.11 to 2.95; P = 0.018), but not O\/S-SSI (HR 1.02, 95% c.i. 0.78 to 1.34; P = 0.888). However, O\/S-SSI was independently associated with reduced overall survival at 1 year (HR 2.20, 95% c.i. 1.39 to 3.48; P &amp;lt; 0.001), 2 years (HR 1.75, 95% c.i. 1.25 to 2.43; P &amp;lt; 0.001), and 5 years (HR 1.33, 95% c.i. 1.05 to 1.68; P = 0.017).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this study, O\/S-SSI had a negative impact on the long-term survival of patients who underwent rectal cancer surgery, but was not associated with increased tumour recurrence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf052","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T09:56:31Z","timestamp":1749722191000},"source":"Crossref","is-referenced-by-count":2,"title":["Organ\/space surgical site infection and long-term outcomes of rectal cancer surgery: retrospective population-based cohort study"],"prefix":"10.1093","volume":"9","author":[{"given":"Carlota","family":"Matallana","sequence":"first","affiliation":[{"name":"Department of Surgery, Universitat Aut\u00f2noma de Barcelona , Bellaterra, Barcelona ,","place":["Spain"]},{"name":"Department of Surgery, Hospital Universitari Parc Taul\u00ed , Sabadell ,","place":["Spain"]},{"name":"Catalan Cancer Plan, Health Department, Duran i Reynals Hospital , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-0577","authenticated-orcid":false,"given":"Paula","family":"Manchon-Walsh","sequence":"additional","affiliation":[{"name":"Catalan Cancer Plan, Health Department, Duran i Reynals Hospital , Barcelona ,","place":["Spain"]},{"name":"Biomedical Research Institute of Bellvitge (IDIBELL), University of Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloy","family":"Esp\u00edn","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Vall d'Hebr\u00f3n University Hospital , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital del Mar , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-0371","authenticated-orcid":false,"given":"Sebastiano","family":"Biondo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitari de Bellvitge , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Jim\u00e9nez-Toscano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital del Mar , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Maria","family":"Borr\u00e0s","sequence":"additional","affiliation":[{"name":"Catalan Cancer Plan, Health Department, Duran i Reynals Hospital , Barcelona ,","place":["Spain"]},{"name":"Biomedical Research Institute of Bellvitge (IDIBELL), University of Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-5233","authenticated-orcid":false,"given":"Josep M","family":"Badia","sequence":"additional","affiliation":[{"name":"Department of Surgery, Granollers General Hospital, School of Medicine, Universitat Internacional de Catalunya , Barcelona ,","place":["Spain"]},{"name":"Health Department, VINCat Program, Surveillance of Healthcare Related Infections in Catalonia , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Lim\u00f3n","sequence":"additional","affiliation":[{"name":"Health Department, VINCat Program, Surveillance of Healthcare Related Infections in Catalonia , Barcelona ,","place":["Spain"]},{"name":"Department of Public Health, Mental Health and Mother\u2013Infant Nursing, Faculty of Nursing, University of Barcelona , Barcelona ,","place":["Spain"]},{"name":"Infectious Diseases Networking Biomedical Research Centre (CIBERINFEC), Carlos III Institute , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Aliste","sequence":"additional","affiliation":[{"name":"Catalan Cancer Plan, Health Department, Duran i Reynals Hospital , Barcelona ,","place":["Spain"]},{"name":"Biomedical Research Institute of Bellvitge (IDIBELL), University of Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Font","sequence":"additional","affiliation":[{"name":"Catalan Cancer Plan, Health Department, Duran i Reynals Hospital , Barcelona ,","place":["Spain"]},{"name":"Biomedical Research Institute of Bellvitge (IDIBELL), University of Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-6481","authenticated-orcid":false,"given":"Miguel","family":"Pera","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Institute of Digestive and Metabolic Diseases (ICMDM), Hospital Cl\u00ednic Barcelona, University of Barcelona , Barcelona ,","place":["Spain"]},{"name":"Gastrointestinal and Pancreatic Oncology Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS) , Barcelona 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