{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:22:23Z","timestamp":1788416543324,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015613","name":"Lille University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pain relief is an important aspect of recovery after open liver resection. This randomized open-label single-centre trial assessed the efficacy of intravenous (i.v.) analgesia alone or in combination with catheter wound infusion (CWI) or intrathecal morphine (ITM) after open liver resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adult patients undergoing open liver resection were randomly assigned to receive either i.v. analgesia alone or in combination with ITM or CWI. In this study, i.v. analgesia consisted of systematic i.v. paracetamol and i.v. morphine via a patient-controlled analgesia pump, with i.v. nefopam as rescue analgesia for a Numeric Rating Scale (NRS) score &amp;gt; 4. The primary outcome was cumulative morphine dose at 24\u2005hours (h). Secondary outcomes included pain intensity, cumulative opioid use at 48 and 72\u2005h, and postoperative complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all, 186 patients were included in the study (62 patients in each group). The median 24-h morphine dose was 14 (interquartile range (i.q.r.) 6\u201325)\u2005mg in the i.v. analgesia group, 14 (i.q.r. 7\u201323)\u2005mg in the CWI group, and 7 (i.q.r. 3\u201315)\u2005mg in the ITM group. ITM significantly reduced morphine use compared with i.v. analgesia alone (mean difference on log-transformed values 0.57; 95% confidence interval 0.21 to 0.93; Bonferroni-adjusted P = 0.002) and lowered pain scores during the first 12\u2005h. No significant differences were observed between the CWI and i.v. analgesia groups. By 72\u2005h, cumulative opioid use was similar across all groups. Adverse events and postoperative complications were comparable across the three groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>ITM reduced the cumulative morphine dose and pain intensity in the first 24\u2005h after liver resection, providing a valuable option for postoperative analgesia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration number<\/jats:title>\n                  <jats:p>NCT03238430 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf074","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:59:46Z","timestamp":1752580786000},"source":"Crossref","is-referenced-by-count":2,"title":["Comparison of catheter wound infusion, intrathecal morphine, and intravenous analgesia for postoperative pain management in open liver resection: randomized clinical trial"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9118-8840","authenticated-orcid":false,"given":"Damien","family":"Rousseleau","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hospital Claude Huriez, Lille University Hospital, F59000-Lille ,","place":["France"]},{"name":"ULR 7365-GRITA-Groupe de Recherche sur les formes Injectables et les Technologies Associ\u00e9es, Lille University , F59000-Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barth\u00e9l\u00e9my","family":"Plane","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hospital Claude Huriez, Lille University Hospital, F59000-Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, CHU 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