{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:29Z","timestamp":1787008529777,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011684","name":"The Crohn\u2019s & Colitis Foundation","doi-asserted-by":"publisher","award":["974823"],"award-info":[{"award-number":["974823"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic anastomotic leakage (AL) is the most common cause of pouch failure after restorative proctocolectomy with ileal pouch\u2013anal anastomosis for ulcerative colitis. This study investigated factors associated with AL and successful salvage of leaking anastomoses after ileoanal pouch surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This multicentre retrospective cohort study included patients aged \u2265 18 years with ulcerative colitis or unclassified inflammatory bowel disease who underwent ileoanal pouch surgery between 2016 and 2021 in six European centres, with a &amp;gt; 12-month follow-up. The primary outcome was AL rate. Secondary outcomes included factors associated with AL occurrence, timing of AL diagnosis (early (&amp;lt; 21 days) versus late), AL management, AL salvage rate, and stoma-free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 411 patients were included, of whom 13.6% (56) had a diagnosed AL. The rate of AL was significantly higher in low-volume (less than ten procedures annually) centres (28.0% versus 12.7%; P = 0.031). Of the 56 ALs, 44 were diagnosed as early leaks and 12 were diagnosed as late leaks. A three-stage approach was associated with late diagnosis and treatment. AL was managed using various techniques, including diverting ileostomy, antibiotics, and drainage. The overall AL salvage rate was 85.4%, but increased to 92% when diagnosed and treated early (compared with 60% when diagnosed and treated late; P = 0.010). Successful AL salvage was associated with long-term stoma-free status (P = 0.002). The median follow-up was 3.8 years (range 1.0\u20138.1 years). The long-term stoma-free rate was 95.5% in patients with AL diagnosed and treated early, but only 41.7% when diagnosed and treated late (P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early diagnosis and treatment of AL diminishes the negative effect of AL after ileoanal pouch surgery. Proactive anastomotic assessment enable early diagnosis and management, especially in patients undergoing a three-stage approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf110","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:36:08Z","timestamp":1753788968000},"source":"Crossref","is-referenced-by-count":4,"title":["Anastomotic leakage after ileoanal pouch surgery: risk factors and salvage rate"],"prefix":"10.1093","volume":"9","author":[{"given":"Tycho B","family":"Moojen","sequence":"first","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centre , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malaika S","family":"Vlug","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centre , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1432-9606","authenticated-orcid":false,"given":"Eva","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centre , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud A","family":"Reijntjes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centre , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan F M","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, University Medical Centre Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-9287","authenticated-orcid":false,"given":"Gabriele","family":"Bislenghi","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, UZ Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Carvello","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Humanitas Clinical and Research Center, IRCCS\u2014Rozzano , Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-2833","authenticated-orcid":false,"given":"Janindra","family":"Warusavitarne","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, St Mark's Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-8950","authenticated-orcid":false,"given":"Roel","family":"Hompes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centre , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurents P S","family":"Stassen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar D","family":"Faiz","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, St Mark's Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1493-1768","authenticated-orcid":false,"given":"Antonino","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Humanitas Clinical and Research Center, IRCCS\u2014Rozzano , Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"D\u2019Hoore","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, UZ Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centre , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"2025092506413809700_zraf110-B1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/BF01295733","article-title":"Clinical patterns, natural history, and progression of ulcerative colitis. 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