{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:30Z","timestamp":1787008530439,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMW","doi-asserted-by":"publisher","award":["10070012010003"],"award-info":[{"award-number":["10070012010003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with the most advanced stages of high-risk locally advanced rectal cancer (LARC), extensive resections often lead to morbidity and functional impairment. It is unclear whether these patients, despite poor prognosis, are suitable candidates for a watch-and-wait (W&amp;W) approach in cases of a clinical complete response (cCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with high-risk LARC who underwent total neoadjuvant therapy (TNT), followed by surgery or a W&amp;W approach between January 2016 and February 2023, were retrospectively analysed. High-risk features included tumour invasion into the mesorectal fascia, grade 4 extramural venous invasion, enlarged lateral lymph nodes, or tumour deposits. Patients were categorized into complete response (CR) or non-CR, and stratified by W&amp;W and surgically treated. Outcomes were regrowth, local recurrence, distant metastases (DM), regrowth-free survival, organ survival, local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), recurrence-free survival (RFS) (all death-censored), and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 135 patients, 29 (21.5%) achieved a cCR and entered W&amp;W. A total of 103 patients (78.0%) underwent immediate surgery, including 15 (11.1%) with a pathological CR. Median follow-up was 42 months (range 9\u201376) for CR patients versus 42.5 months (range 7\u201382) for non-CR patients. Local recurrence and DM occurred in 1 (2.3%) and 7 patients (15.9%) in the CR group, respectively, versus 14 (15.9%) and 21 patients (23.9%) in the non-CR group, respectively. Three-year death-censored LRFS and DMFS rates were 97.6% and 82.7% in the CR group, respectively, versus 85.8% and 76.0% in the non-CR group, respectively (P = 0.016, P = 0.273). Five-year overall survival was 89.5% in the CR group versus 84.0% in the non-CR group (P = 0.131). Median follow-up was 44 months (range 16\u201371) in W&amp;W patients and 42 months (range 7\u201382) in surgically treated patients. Among W&amp;W patients, regrowth occurred in seven patients (24.1%) and the 3-year death-censored regrowth-free survival was 79.2%. Three-year death-censored RFS and 5-year overall survival were 71.9% and 90.9% in W&amp;W patients, respectively, versus 72.3% and 84.2% in surgically treated patients, respectively (P = 0.680, P = 0.115).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A W&amp;W approach can be considered safe and feasible for patients with high-risk LARC. Achieving a CR after TNT is associated with favourable oncological outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf136","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T06:48:41Z","timestamp":1762670921000},"source":"Crossref","is-referenced-by-count":5,"title":["Watch-and-wait approach in high-risk locally advanced rectal cancer: outcomes after complete response to total neoadjuvant therapy"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6684-0101","authenticated-orcid":false,"given":"Evi","family":"Banken","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"GROW Research Institute for Oncology and Reproduction, Faculty of Health, Medicine and Life Science, Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M","family":"Geubels","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"Department of Surgery, Antoni van Leeuwenhoek , Amsterdam ,","place":["The Netherlands"]},{"name":"GROW Research Institute for Oncology and Reproduction, Faculty of Health, Medicine and Life Science, Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur E C","family":"Vande Kerckhove","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"GROW Research Institute for Oncology and Reproduction, Faculty of Health, Medicine and Life Science, Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8444-3865","authenticated-orcid":false,"given":"Davy M J","family":"Creemers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"GROW Research Institute for Oncology and Reproduction, Faculty of Health, Medicine and Life Science, Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn H J","family":"Ketelaers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"Department of Surgery, Maastricht Academic Medical Center , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Nederend","sequence":"additional","affiliation":[{"name":"Department of Radiology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike M U","family":"Peulen","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene E G","family":"van Hellemond","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm J T","family":"Rutten","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"GROW Research Institute for Oncology and Reproduction, Faculty of Health, Medicine and Life Science, Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus W A","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"GROW Research Institute for Oncology and Reproduction, Faculty of Health, Medicine and Life Science, Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"2025110901483829100_zraf136-B1","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1200\/JCO.2011.40.1836","article-title":"Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO\/ARO\/AIO-94 randomized phase III trial after a median follow-up of 11 years","volume":"30","author":"Sauer","year":"2012","journal-title":"J Clin Oncol"},{"key":"2025110901483829100_zraf136-B2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial","volume":"12","author":"van Gijn","year":"2011","journal-title":"Lancet Oncol"},{"key":"2025110901483829100_zraf136-B3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/DCR.0000000000000547","article-title":"Treatment of locally recurrent rectal carcinoma in previously (chemo)irradiated patients","volume":"59","author":"van der Meij","year":"2016","journal-title":"Dis Colon Rectum"},{"key":"2025110901483829100_zraf136-B4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00000478-200203000-00009","article-title":"Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma","volume":"26","author":"Nagtegaal","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"2025110901483829100_zraf136-B5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.ijrobp.2021.06.013","article-title":"Prognostic implications of MRI-detected EMVI and tumor deposits and their response to neoadjuvant therapy in cT3 and cT4 rectal cancer","volume":"111","author":"Schaap","year":"2021","journal-title":"Int J Radiation Oncol Biol Phys"},{"key":"2025110901483829100_zraf136-B6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1200\/JCO.18.00032","article-title":"Neoadjuvant (chemo)radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter lateral node study of patients with low cT3\/4 rectal cancer","volume":"37","author":"Ogura","year":"2019","journal-title":"J Clin Oncol"},{"key":"2025110901483829100_zraf136-B7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1200\/JCO.2016.68.9091","article-title":"Tumor deposits in colorectal cancer: improving the value of modern staging\u2014a systematic review and meta-analysis","volume":"35","author":"Nagtegaal","year":"2017","journal-title":"J Clin Oncol"},{"key":"2025110901483829100_zraf136-B8","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/bjc.2017.99","article-title":"A meta-analysis comparing the risk of metastases in patients with rectal cancer and MRI-detected extramural vascular invasion (mrEMVI) vs mrEMVI-negative cases","volume":"116","author":"Siddiqui","year":"2017","journal-title":"Br J Cancer"},{"key":"2025110901483829100_zraf136-B9","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/SLA.0000000000004499","article-title":"MRI-diagnosed tumor deposits and EMVI status have superior prognostic accuracy to current clinical TNM staging in rectal cancer","volume":"276","author":"Lord","year":"2022","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B10","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/01.sla.0000205627.05769.08","article-title":"Extent of mesorectal tumor invasion as a prognostic factor after curative surgery for T3 rectal cancer patients","volume":"243","author":"Miyoshi","year":"2006","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/01.sla.0000171299.43954.ce","article-title":"Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer","volume":"242","author":"Hendren","year":"2005","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B12","doi-asserted-by":"crossref","first-page":"944843","DOI":"10.3389\/fonc.2022.944843","article-title":"Quality of life and function after rectal cancer surgery with and without sphincter preservation","volume":"12","author":"Pappou","year":"2022","journal-title":"Front Oncol"},{"key":"2025110901483829100_zraf136-B13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/bjs5.75","article-title":"Cohort study of long-term survival and quality of life following pelvic exenteration","volume":"2","author":"Steffens","year":"2018","journal-title":"BJS Open"},{"key":"2025110901483829100_zraf136-B14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.radonc.2021.05.014","article-title":"Watch-and-wait strategy in rectal cancer: is there a tumour size limit? Results from two pooled prospective studies","volume":"160","author":"Jankowski","year":"2021","journal-title":"Radiother Oncol"},{"key":"2025110901483829100_zraf136-B15","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1097\/SLA.0000000000005755","article-title":"Negative prognostic impact of tumor deposits in rectal cancer","volume":"278","author":"Agger","year":"2023","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B16","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1186\/s12885-022-09947-w","article-title":"Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk (\u201cugly\u201d) locally advanced rectal cancer: study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT)","volume":"22","author":"van den Berg","year":"2022","journal-title":"BMC Cancer"},{"key":"2025110901483829100_zraf136-B17","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.sla.0000141194.27992.32","article-title":"Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy","volume":"240","author":"Habr-Gama","year":"2004","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1470-2045(20)30557-X","article-title":"Conditional recurrence-free survival of clinical complete responders managed by watch and wait after neoadjuvant chemoradiotherapy for rectal cancer in the International Watch & Wait Database: a retrospective, international, multicentre registry study","volume":"22","author":"Fernandez","year":"2021","journal-title":"Lancet Oncol"},{"key":"2025110901483829100_zraf136-B19","doi-asserted-by":"crossref","first-page":"djw171","DOI":"10.1093\/jnci\/djw171","article-title":"Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer","volume":"108","author":"Martens","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"2025110901483829100_zraf136-B20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1097\/SLA.0b013e3182759f1c","article-title":"Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy","volume":"256","author":"Smith","year":"2012","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B21","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S1470-2045(15)00120-5","article-title":"High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study","volume":"16","author":"Appelt","year":"2015","journal-title":"Lancet Oncol"},{"key":"2025110901483829100_zraf136-B22","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/DCR.0000000000000862","article-title":"Quality of life in rectal cancer patients after chemoradiation: watch-and-wait policy versus standard resection\u2014a matched-controlled study","volume":"60","author":"Hupkens","year":"2017","journal-title":"Dis Colon Rectum"},{"key":"2025110901483829100_zraf136-B23","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/S0140-6736(18)31078-X","article-title":"Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study","volume":"391","author":"van der Valk","year":"2018","journal-title":"Lancet"},{"key":"2025110901483829100_zraf136-B24","doi-asserted-by":"crossref","first-page":"e766","DOI":"10.1097\/SLA.0000000000005799","article-title":"Locoregional failure during and after short-course radiotherapy followed by chemotherapy and surgery compared with long-course chemoradiotherapy and surgery","volume":"278","author":"Dijkstra","year":"2023","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B25","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1200\/JCO.21.01667","article-title":"Multicenter, randomized, phase III trial of short-term radiotherapy plus chemotherapy versus long-term chemoradiotherapy in locally advanced rectal cancer (STELLAR)","volume":"40","author":"Jin","year":"2022","journal-title":"J Clin Oncol"},{"key":"2025110901483829100_zraf136-B26","doi-asserted-by":"crossref","first-page":"e180071","DOI":"10.1001\/jamaoncol.2018.0071","article-title":"Adoption of total neoadjuvant therapy for locally advanced rectal cancer","volume":"4","author":"Cercek","year":"2018","journal-title":"JAMA Oncol"},{"key":"2025110901483829100_zraf136-B27","doi-asserted-by":"crossref","first-page":"e2030097","DOI":"10.1001\/jamanetworkopen.2020.30097","article-title":"Total neoadjuvant therapy vs standard therapy in locally advanced rectal cancer","volume":"3","author":"Kasi","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2025110901483829100_zraf136-B28","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S1470-2045(21)00079-6","article-title":"Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial","volume":"22","author":"Conroy","year":"2021","journal-title":"Lancet Oncol"},{"key":"2025110901483829100_zraf136-B29","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1200\/JCO.23.01208","article-title":"Long-term results of organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy: the randomized phase II OPRA trial","volume":"42","author":"Verheij","year":"2024","journal-title":"J Clin Oncol"},{"key":"2025110901483829100_zraf136-B30","author":"Federatie Medisch Specialisten. Colorectaal Carcinoom","year":"2020"},{"key":"2025110901483829100_zraf136-B31","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00330-017-5026-2","article-title":"Magnetic resonance imaging for clinical management of rectal cancer: updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting","volume":"28","author":"Beets-Tan","year":"2018","journal-title":"Eur Radiol"},{"key":"2025110901483829100_zraf136-B32","author":"Federatie Medisch Specialisten. Colorectaal Carcinoom","year":"2020"},{"key":"2025110901483829100_zraf136-B33","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/SLA.0000000000002761","article-title":"Oncological and survival outcomes in watch and wait patients with a clinical complete response after neoadjuvant chemoradiotherapy for rectal cancer","volume":"268","author":"Dattani","year":"2018","journal-title":"Ann Surg"},{"key":"2025110901483829100_zraf136-B34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S2468-1253(18)30301-7","article-title":"Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis","volume":"3","author":"Chadi","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2025110901483829100_zraf136-B35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S2468-1253(17)30074-2","article-title":"A watch-and-wait approach for locally advanced rectal cancer after a clinical complete response following neoadjuvant chemoradiation: a systematic review and meta-analysis","volume":"2","author":"Dossa","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2025110901483829100_zraf136-B36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(15)00467-2","article-title":"Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis","volume":"17","author":"Renehan","year":"2016","journal-title":"Lancet Oncol"},{"key":"2025110901483829100_zraf136-B37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/DCR.0000000000002197","article-title":"Outcomes of patients with local regrowth after nonoperative management of rectal cancer after neoadjuvant chemoradiotherapy","volume":"65","author":"Cotti","year":"2022","journal-title":"Dis Colon Rectum"},{"key":"2025110901483829100_zraf136-B38","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1245\/s10434-011-2209-y","article-title":"Complete pathologic response after combined modality treatment for rectal cancer and long-term survival: a meta-analysis","volume":"19","author":"Zorcolo","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"2025110901483829100_zraf136-B39","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1200\/JCO.2011.39.7901","article-title":"Neoadjuvant treatment response as an early response indicator for patients with rectal cancer","volume":"30","author":"Park","year":"2012","journal-title":"J Clin Oncol"},{"key":"2025110901483829100_zraf136-B40","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1245\/s10434-008-0149-y","article-title":"A simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy","volume":"15","author":"Beddy","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"2025110901483829100_zraf136-B41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.23736\/S0026-4733.18.07743-X","article-title":"Non-operative management of rectal cancer: understanding tumor biology","volume":"73","author":"Wei","year":"2018","journal-title":"Minerva Chir"},{"key":"2025110901483829100_zraf136-B42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejca.2023.02.027","article-title":"Risk and location of distant metastases in patients with locally advanced rectal cancer after total neoadjuvant treatment or chemoradiotherapy in the RAPIDO trial","volume":"185","author":"Bahadoer","year":"2023","journal-title":"Eur J Cancer"},{"key":"2025110901483829100_zraf136-B43","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.radonc.2016.11.010","article-title":"Two countries\u2014two treatment strategies for rectal cancer","volume":"121","author":"Glimelius","year":"2016","journal-title":"Radiother Oncol"},{"key":"2025110901483829100_zraf136-B44","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.3390\/cancers12113308","article-title":"Recurrence risk after radical colorectal cancer surgery\u2014less than before, but how high is it?","volume":"12","author":"Osterman","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2025110901483829100_zraf136-B45","doi-asserted-by":"crossref","first-page":"102829","DOI":"10.1016\/j.ctrv.2024.102829","article-title":"Induction treatment with FOLFIRINOX or oxaliplatin-based doublet followed by long-course chemoradiotherapy and surgery in locally advanced rectal cancer. A systematic review and pooled analysis from phase II and III trials","volume":"130","author":"Moretto","year":"2024","journal-title":"Cancer Treat Rev"},{"key":"2025110901483829100_zraf136-B46","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1186\/s12885-024-12529-7","article-title":"Alliance A022104\/NRG-GI010: the Janus Rectal Cancer Trial: a randomized phase II\/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer","volume":"24","author":"Alvarez","year":"2024","journal-title":"BMC Cancer"}],"container-title":["BJS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/9\/6\/zraf136\/65236092\/zraf136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/9\/6\/zraf136\/65236092\/zraf136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T06:48:46Z","timestamp":1762670926000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjsopen\/article\/doi\/10.1093\/bjsopen\/zraf136\/8315990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/bjsopen\/zraf136","relation":{},"ISSN":["2474-9842"],"issn-type":[{"value":"2474-9842","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,10,30]]},"article-number":"zraf136"}}