{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:10:58Z","timestamp":1767899458340,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Surgical Research Support Centre"},{"DOI":"10.13039\/100012921","name":"Royal College of Surgeons in Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Major lower extremity amputations are frequently performed for end-stage peripheral arterial disease and progressive diabetic foot complications. Wound complications after amputation affect up to one-third of limbs. The patient cohort undergoing amputation are typically high risk for poor wound healing, often with unmodifiable risk factors in an urgent clinical setting. Incisional negative pressure wound therapy (NPWT) has been shown to reduce wound complications in other high-risk populations. This randomized controlled trial investigates whether prophylactic NPWT reduces wound complications in patients after major amputation compared with standard dry dressings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This protocol describes a prospective, multicentre, randomized controlled trial with an internal pilot recruiting patients undergoing major lower extremity amputation for any indication. Limbs will be randomized to receive either a single-use NPWT device on their closed surgical incision or a dry dressing. The primary clinical outcome is the rate of wound complications. Secondary outcomes include reoperation rates, length of hospital stay, cost-effectiveness of NPWT, and patient-reported quality of life. Follow-up will continue to 6 months after surgery. The initial pilot phase has a recruitment target of 96 limbs, whereas an estimated 728 patients will be required to power a definitive trial adequately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This trial aims to supplement the existing poor-quality data on this important aspect of care and equip healthcare professionals to make cost-effective decisions regarding postoperative wound management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf159","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:13:08Z","timestamp":1763557988000},"source":"Crossref","is-referenced-by-count":0,"title":["Prophylactic Incisional Negative Pressure wound therapy (NPWT) for major Amputations (PINTA): protocol for randomized controlled trial of single-use NPWT devices for closed-incision major lower extremity amputations"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-3182","authenticated-orcid":false,"given":"Megan","family":"Power Foley","sequence":"first","affiliation":[{"name":"University Hospital Galway Department of Vascular Surgery, , Newcastle Road, Galway ,","place":["Ireland"]},{"name":"Irish Surgical Research Collaborative , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciara","family":"Fahey","sequence":"additional","affiliation":[{"name":"National Surgical Research Support Centre, Royal College of Surgeons Ireland , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Byrne","sequence":"additional","affiliation":[{"name":"National Surgical Research Support Centre, Royal College of Surgeons Ireland , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rois\u00edn","family":"Leahy","sequence":"additional","affiliation":[{"name":"National Surgical Research Support Centre, Royal College of Surgeons Ireland , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Dempsey","sequence":"additional","affiliation":[{"name":"National Surgical Research Support Centre, Royal College of Surgeons Ireland , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Westby","sequence":"additional","affiliation":[{"name":"University Hospital Galway Department of Vascular Surgery, , Newcastle Road, Galway ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart R","family":"Walsh","sequence":"additional","affiliation":[{"name":"University Hospital Galway Department of Vascular Surgery, , Newcastle Road, Galway ,","place":["Ireland"]},{"name":"National Surgical Research Support Centre, Royal College of Surgeons Ireland , Dublin ,","place":["Ireland"]},{"name":"Lambe Institute for Translational Research, University of Galway , Galway ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"2026010809302419700_zraf159-B1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejvs.2020.03.018","article-title":"Trends in surgical indications for major lower limb amputation in the USA from 2000 to 2016","volume":"60","author":"Kalbaugh","year":"2020","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2026010809302419700_zraf159-B2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ejvs.2018.04.017","article-title":"International variations in amputation practice: a VASCUNET report","volume":"56","author":"Behrendt","year":"2018","journal-title":"Eur J Vasc Endovasc 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