{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:32:48Z","timestamp":1771342368244,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Society of Surgical Oncology","award":["KSSO-21-05"],"award-info":[{"award-number":["KSSO-21-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nipple-sparing mastectomy (NSM) is a surgical option offering both oncological safety and cosmetic benefits. However, the oncological safety of NSM in carriers of BRCA1\/2 pathogenic variants\/likely pathogenic variants (PV\/LPV) with breast cancer and the role of risk-reducing mastectomy remain underexplored, especially in Asian populations. This study evaluated the safety and effectiveness of NSM in BRCA1\/2 PV\/LPV carriers and assessed the preventive impact of contralateral risk-reducing NSM (RRNSM) on cancer incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre retrospective study included women aged 20\u201380 years who underwent NSM for therapeutic or risk-reducing purposes and received germline BRCA1\/2 tests between May 2006 and June 2022 across 19 institutions in Korea. Patients with distant metastasis at diagnosis were excluded. Information on demographics, the clinical characteristics of patients and tumours, surgical details, and follow-up outcomes was collected from a review the medical records of each participating institution. The primary outcome was the oncological safety of NSM, assessed by comparing ipsilateral local recurrence rates between patients with and without BRCA1\/2 PV\/LPV. The secondary outcome was cancer incidence in patients who underwent contralateral RRNSM versus those who did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 787 women underwent 906 NSMs, with a median (interquartile range) follow-up of 59.3 (44.0\u201382.8) months. Among the participants, 186 (23.6%) were BRCA1\/2 PV\/LPV carriers. Ipsilateral local recurrence rates were comparable between BRCA1\/2 PV\/LPV carriers and non-carriers (6.4 versus 7.4%, respectively). The 5-year local recurrence-free survival rates did not differ significantly between BRCA1\/2 PV\/LPV carriers and non-carriers (92.2% versus 93.2%, respectively; P = 0.87). Contralateral breast cancer occurred in 4.5% of patients with BRCA1\/2 PV\/LPV who did not undergo contralateral RRNSM, whereas no cases of contralateral breast cancer were reported among patients who underwent RRNSM regardless of BRCA1\/2 status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights NSM as a safe and effective surgical option for BRCA1\/2 PV\/LPV carriers with breast cancer, as well as a risk-reducing strategy. Further prospective studies are needed to confirm these findings and evaluate long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf168","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:56:35Z","timestamp":1765284995000},"source":"Crossref","is-referenced-by-count":0,"title":["Oncological safety and preventive impact of nipple-sparing mastectomy in patients with\n                    <i>BRCA1\/2<\/i>\n                    mutation: multicentre study of the Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG)"],"prefix":"10.1093","volume":"10","author":[{"given":"Hong-Kyu","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8915-8944","authenticated-orcid":false,"given":"Dong Seung","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Yoon","family":"Jang","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery, Jeju National University Hospital, Jeju National University School of Medicine , Jeju ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soong June","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihwan David","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hanyang University Medical Center, Hanyang University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeeyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Hospital , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Shin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yeungnam University College of Medicine , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Youn","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-2218","authenticated-orcid":false,"given":"Hee-Chul","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seongnam ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Daerim St. Mary's Hospital , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keimyung University School of Medicine , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Yeup","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Ah","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janghee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine , Seoul ,","place":["Korea"]},{"name":"Department of Medicine, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Woo","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Ansan Hospital, Korea University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwon","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dankook University College of Medicine , Cheonan ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Hallym University , Anyang ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Joon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Incheon St. Mary\u2019s Hospital, The Catholic University of Korea , Incheon ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine , Changwon ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae Byul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Min","family":"Ryu","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Korea Robot-endoscopy Minimal Access Breast Surgery 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