{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:53:41Z","timestamp":1770814421477,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between surgeon volume and patient outcomes in adrenalectomy is well established in the literature and clinical guidelines. However, evidence regarding the impact of centre volume on patient outcomes remains limited. This study aimed to evaluate the effect of centre volume on patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre study analysed adrenalectomy procedures from the EUROCRINE\u00ae registry (2015\u20132024). A volume threshold was determined using receiver operating characteristic curve analysis to predict high-grade complications (Clavien\u2013Dindo grade \u2265 III). Outcomes were compared between high- and low-volume centres, and multivariable logistic regression was used to identify independent predictors of complications and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 6672 patients undergoing adrenalectomy from 99 centres across Europe were included. The optimal centre volume threshold was \u2265 36 adrenalectomies per year. Only seven centres (7%) met this threshold, accounting for 36.7% of all procedures. High-volume centres had significantly lower rates of high-grade complications (0.9 versus 2.9%; P &amp;lt; 0.001), conversion (2.3 versus 3.5%), and reoperation (0.7 versus 1.6%), and shorter hospital stays (median 2 versus 3 days). Multivariable analysis showed high-volume centre status to be independently protective against high-grade complications (odds ratio 0.39, 95% confidence interval 0.24 to 0.63; P &amp;lt; 0.001), but not postoperative mortality (odds ratio 0.69; P = 0.480). Functional benign tumours compared with malignant tumours (odds ratio 0.61, 0.39 to 0.93; P = 0.020) and minimally invasive surgery (odds ratio 0.21, 0.14 to 0.31; P &amp;lt; 0.001) were both associated with a significantly lower risk of high-grade complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Centre adrenalectomy volume is a key determinant of high-grade complication risk following adrenalectomy. A threshold of \u2265 36 adrenalectomies per year identifies high-performing centres. These findings support centralization of adrenal surgery to optimize outcomes and standardize care across institutions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zraf180","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:54:58Z","timestamp":1766494498000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of centre volume on adrenalectomy outcomes: European multicentre study based on EUROCRINE\u00ae registry"],"prefix":"10.1093","volume":"10","author":[{"given":"Yi\u011fit","family":"T\u00fcrk","sequence":"first","affiliation":[{"name":"Division of Endocrine Surgery, Department of General Surgery, Ege University Hospital , Izmir ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8091-3071","authenticated-orcid":false,"given":"Aykut","family":"\u00d6zk\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of General Surgery, Ege University Hospital , Izmir ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-700X","authenticated-orcid":false,"given":"Francesco","family":"Pennestri","sequence":"additional","affiliation":[{"name":"UOC di Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Rome ,","place":["Italy"]},{"name":"Centro di Ricerca in Chirurgia Delle Ghiandole Endocrine e Dell\u2019Obesit\u00e0 (CREO), Universit\u00e0 Cattolica del Sacro Cuore , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Raffaelli","sequence":"additional","affiliation":[{"name":"UOC di Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Rome ,","place":["Italy"]},{"name":"Centro di Ricerca in Chirurgia Delle Ghiandole Endocrine e Dell\u2019Obesit\u00e0 (CREO), Universit\u00e0 Cattolica del Sacro Cuore , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Churchill Cancer Centre, Oxford University Hospitals NHS Foundation Trust , Oxford ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of General Surgery, Ege University Hospital , Izmir ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-6748","authenticated-orcid":false,"given":"\u00d6zer","family":"Makay","sequence":"additional","affiliation":[{"name":"Centre for Endocrine Surgery, \u00d6zel Sa\u011fl\u0131k Hospital , \u0130zmir ,","place":["T\u00fcrkiye"]},{"name":"School of Medicine, Aristotle University , Thessaloniki ,","place":["Greece"]},{"name":"Instituto Portugu\u00eas De Oncologia De Coimbra Francisco Gentil , Department of Surgery, Coimbra ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"2026021010071562900_zraf180-B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.surg.2017.04.028","article-title":"Each procedure matters: threshold for surgeon volume to minimize complications and decrease cost associated with adrenalectomy","volume":"163","author":"Anderson","year":"2018","journal-title":"Surgery"},{"key":"2026021010071562900_zraf180-B2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/cen.13021","article-title":"Adrenal surgery in England: better outcomes in high-volume practices","volume":"85","author":"Palazzo","year":"2016","journal-title":"Clin Endocrinol 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