{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:59:12Z","timestamp":1782233952770,"version":"3.54.5"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beca FIS Instituto Carlos III"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beca la Marat\u00f3"},{"name":"Beca Tamarite AEG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate locoregional staging is critical in the management of T1 rectal cancer and guides organ-preserving strategies. Despite guideline recommendations, the real-world performance of magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) remains unclear. This study aims to evaluate the use and accuracy of locoregional staging in T1 rectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis was performed from a nationwide multicentre T1 colorectal cancer cohort (EpiT1 Consortium) between 2007 and 2018 with a 5-year follow-up. Locoregional staging methods included MRI and EUS. Multivariable logistic regression identified factors associated with locoregional imaging. The accuracy of each technique and their combination for T and N staging was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 3161 patients with T1 colorectal cancer, 681 had rectal cancer, of which 424 (62.3%) underwent locoregional staging: 234 (55.2%) with MRI only, 131 (30.9%) with both MRI and EUS, and 59 (13.9%) with EUS only. Factors associated with imaging (MRI and EUS) included management at a referral centre (odds ratio 2.9, 95% confidence interval 1.5 to 5.7), tumour location in the low\/middle rectum (odds ratio 3.2, 1.8 to 5.7), suspicion of invasive carcinoma at colonoscopy (odds ratio 2.4, 1.3 to 4.5), and high-risk histological features (odds ratio 3.7, 1.8 to 7.4). MRI accurately staged T in 28.3%, whereas EUS achieved an accuracy of 59% for T staging. Combining modalities overstaged 67.1% of tumours for T staging. N staging was detected with \u2264 16% sensitivity across all strategies; in the surgical group (MRI and\/or EUS), overall accuracy was 78%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Locoregional staging varied widely and was influenced by non-tumour-related factors. MRI and EUS showed modest accuracy, overstaging T, and low sensitivity for N. These findings highlight the need to improve pretreatment evaluation of T1 rectal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrag003","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:02:37Z","timestamp":1774958557000},"source":"Crossref","is-referenced-by-count":3,"title":["Accuracy and variability of locoregional staging in T1 rectal cancer: nationwide multicentre cohort study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-8865","authenticated-orcid":false,"given":"Maria","family":"Daca-Alvarez","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Hospital Clinic of Barcelona, Clinic Institute of Digestive and Metabolic Disease (ICMDIM) of Barcelona , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Institut d'Investigacions Biom\u00e9diques August Pi i 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