{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:26:51Z","timestamp":1784068011602,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K20950"],"award-info":[{"award-number":["21K20950"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer is associated with gut microbiota alterations, including enrichment of colorectal cancer-associated bacteria such as Fusobacterium nucleatum, Parvimonas micra, and Peptostreptococcus stomatis. However, the impact of curative resection on their postoperative dynamics remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Faecal samples were collected from patients with colorectal cancer and controls. Samples were collected before surgery and at 1 week, 1 month, and 6 months after surgery. Microbial diversity was evaluated using 16S ribosomal RNA sequencing, and F. nucleatum, P. micra, and P. stomatis were quantified by quantitative polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 83 faecal samples were collected from 28 patients with colorectal cancer and 16 healthy controls. Alpha diversity decreased at 1 week and recovered by 1 month. Unweighted unique fraction metric suggested recovery of community membership by 6 months, whereas Bray\u2013Curtis and weighted unique fraction metric remained altered, indicating persistent community reorganization. At the class level, Negativicutes and Clostridia decreased at 1 week and gradually recovered, whereas Bacilli showed a transient increase. In contrast, F. nucleatum, P. micra, and P. stomatis declined significantly after surgery and remained suppressed at 6 months. Patients who developed recurrence had higher preoperative P. micra and P. stomatis levels, though differences were not observed after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Colorectal cancer resection induces an acute postoperative disruption of the gut microbiota, followed by recovery of overall diversity and major taxonomic features, but stabilization in a state that does not fully recapitulate the preoperative microbiota. Colorectal cancer-associated bacteria (F. nucleatum, P. micra, and P. stomatis) remained persistently reduced after surgery, highlighting their dependence on the tumour microenvironment. Monitoring these bacteria in faecal samples may offer a non-invasive means to assess microbiota recovery and potential recurrence risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrag037","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:21:33Z","timestamp":1774268493000},"source":"Crossref","is-referenced-by-count":1,"title":["Short- and long-term dynamics of gut microbiota, highlighting\n                    <i>Fusobacterium nucleatum<\/i>\n                    ,\n                    <i>Parvimonas micra<\/i>\n                    , and\n                    <i>Peptostreptococcus stomatis<\/i>\n                    after colorectal cancer resection: prospective cohort study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-4249","authenticated-orcid":false,"given":"Tomosuke","family":"Mukoyama","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Surgery, Department 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