{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:27:23Z","timestamp":1786944443937,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical School Brandenburg"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sex-based differences in outcomes after oncological surgery remain underexplored despite growing interest in personalized and equitable cancer care. Sex differences in in-hospital mortality and failure-to-rescue rates after major gastrointestinal cancer surgery were analysed using nationwide real-world data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>German Diagnosis Related Groups discharge data from 2010\u20132023 were analysed, including adult patients undergoing curative-intent resections for colorectal, gastric, pancreatic, and oesophageal cancers. Multivariable generalized linear models were applied to estimate adjusted sex-specific risks of in-hospital mortality and failure to rescue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 870 754 patients (376\u2005883, 43.3% women), the overall in-hospital mortality rate was 5.9%. Women had lower adjusted odds of death (20\u2005343 (5.4%) versus 31\u2005265 (6.3%); adjusted odds ratio 0.82, 95% confidence interval 0.81 to 0.84) and failure to rescue (18 097 of 151\u2005616 (11.9%) versus 28 583 of 231\u2005245 (12.4%); adjusted odds ratio 0.92, 0.89 to 0.94) compared with men. The mortality advantage for women was consistent across cancer sites except for oesophageal resection. Temporal analyses showed a continuous decline in mortality and failure to rescue for both sexes over the 14-year study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Female sex was independently associated with lower in-hospital mortality and failure-to-rescue rates after major gastrointestinal cancer surgery in routine clinical practice. Male sex was associated with a higher risk of adverse short-term outcomes, identifying men as a higher-risk group in routine oncological surgical care. Although causal mechanisms cannot be inferred, the results suggest the need for sex-informed perioperative management and rescue strategies to improve the quality of oncological surgical care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrag067","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:43:42Z","timestamp":1776944622000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex-based differences in mortality and failure to rescue after major gastrointestinal cancer resections: real-world evidence from a nationwide cohort"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-6019","authenticated-orcid":false,"given":"Rene","family":"Mantke","sequence":"first","affiliation":[{"name":"Department of General Surgery, University Hospital Brandenburg, Brandenburg Medical School Theodor Fontane , Brandenburg ,","place":["Germany"]},{"name":"Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane , Brandenburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5066-3966","authenticated-orcid":false,"given":"Ulrike","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital Brandenburg, Brandenburg Medical School Theodor Fontane , Brandenburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3666-5675","authenticated-orcid":false,"given":"Markus W","family":"B\u00fcchler","sequence":"additional","affiliation":[{"name":"Botton-Champalimaud Pancreatic Cancer Centre , Champalimaud Foundation, Lisbon ,","place":["Portugal"]},{"name":"Heidelberg University Hospital, Heidelberg Department of General, Visceral and Transplant Surgery, 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