{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:29:32Z","timestamp":1789046972649,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["RS-2022-00165755"],"award-info":[{"award-number":["RS-2022-00165755"]}]},{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HR21C0198"],"award-info":[{"award-number":["HR21C0198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although preoperative exercise is widely promoted within prehabilitation programmes, the association between habitual preoperative exercise and postoperative venous thromboembolism (VTE) remains unclear. This study examined the association between the frequency of preoperative exercise and postoperative VTE risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the National Health Insurance Service\u2013National Sample Cohort (2009\u20132016), adults who underwent surgery and preoperative health screening were identified. Exercise was classified as exerciser versus non-exerciser and by frequency (none, 1\u20132, or \u22653 times\/week). Multivariable logistic regression adjusted for demographic, clinical, and surgical factors was used to estimate VTE risk, with subgroup analyses across demographic and lifestyle strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 118 340 patients were enrolled in this study and categorized based on their exercise habits: non-exercisers (n = 33 351; 28.2%) and exercisers (n = 84 989; 71.8%). Engagement in preoperative exercise was significantly associated with a reduced risk of postoperative VTE (adjusted odds ratio [aOR]: 0.69, 95% confidence interval [c.i.]: 0.49\u20130.99, P = 0.041) compared to the non-exerciser group. A clear dose-response relationship was evident; while exercising 1\u20132 times per week was associated with a lower but non-significant risk (aOR: 0.79, 95% c.i.: 0.48\u20131.26, P = 0.334), the lowest and statistically significant risk was observed among patients exercising \u22653 times per week (aOR: 0.66, 95% c.i.: 0.45\u20130.96, P = 0.031, P for trend = 0.032). Secondary analyses confirmed similar protective trends for deep vein thrombosis, with varying degrees of risk reduction observed for other complications such as stroke. Subgroup analysis indicated that the impact of exercise on outcomes was more pronounced in male and smoking patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative exercise is an independent, modifiable factor associated with a dose-dependent reduction in VTE risk, highlighting its role as a non-pharmacological strategy to enhance surgical safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrag109","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:48:55Z","timestamp":1782866935000},"source":"Crossref","is-referenced-by-count":0,"title":["Association between preoperative physical exercise and the risk of postoperative venous thromboembolism: nationwide population-based cohort study"],"prefix":"10.1093","volume":"10","author":[{"given":"Chan-Sik","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bumwoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Information Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-Seok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine , Gangneung ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hoon","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"2026091008592698200_zrag109-B1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.beha.2012.06.007","article-title":"Venous thromboembolism: epidemiology and magnitude of the problem","volume":"25","author":"Goldhaber","year":"2012","journal-title":"Best Pract Res Clin Haematol"},{"key":"2026091008592698200_zrag109-B2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa012385","article-title":"Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer","volume":"346","author":"Bergqvist","year":"2002","journal-title":"N Engl J Med"},{"key":"2026091008592698200_zrag109-B3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(20)32658-1","article-title":"Venous thromboembolism","volume":"398","author":"Khan","year":"2021","journal-title":"Lancet"},{"key":"2026091008592698200_zrag109-B4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jamasurg.2013.3172","article-title":"Venous thromboembolism after major cancer surgery: temporal trends and patterns of care","volume":"149","author":"Trinh","year":"2014","journal-title":"JAMA Surg"},{"key":"2026091008592698200_zrag109-B5","doi-asserted-by":"crossref","first-page":"e0231411","DOI":"10.1371\/journal.pone.0231411","article-title":"Economic burden of venous thromboembolism in surgical patients: a propensity score analysis from the national claims database in Vietnam","volume":"15","author":"Bui","year":"2020","journal-title":"PLoS One"},{"key":"2026091008592698200_zrag109-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13696998.2024.2436797","article-title":"The burden of venous thromboembolism in ten countries: a cost-of-illness markov model on surgical and ICU patients","volume":"28","author":"Seemann","year":"2025","journal-title":"J Med Econ"},{"key":"2026091008592698200_zrag109-B7","doi-asserted-by":"crossref","first-page":"15006","DOI":"10.1038\/nrdp.2015.6","article-title":"Venous thrombosis","volume":"1","author":"Wolberg","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2026091008592698200_zrag109-B8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/SLA.0000000000002293","article-title":"Personalised prehabilitation in high-risk patients undergoing elective Major abdominal surgery: a randomized blinded controlled trial","volume":"267","author":"Barberan-Garcia","year":"2018","journal-title":"Ann Surg"},{"key":"2026091008592698200_zrag109-B9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bja.2021.12.007","article-title":"Prehabilitation, enhanced recovery after surgery, or both? 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