{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:07:48Z","timestamp":1789124868657,"version":"build-2803163510"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal level of inferior mesenteric artery ligation in rectosigmoid cancer surgery remains a matter of debate. This study evaluated the prognostic impact of low ligation (LL) versus high ligation (HL) after rectal or sigmoid cancer resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A reconstructed individual patient data meta-analysis of randomized clinical trials (RCTs) was performed using restricted mean survival time difference (RMSTD) estimation. PubMed, MEDLINE, Scopus, Web of Science, ClinicalTrials.gov, Cochrane Central Library, and Google Scholar were searched. Primary outcomes were 5-year overall (OS) and disease-free survival (DFS). The RMSTD, risk ratio (RR), standardized mean difference (SMD), and 95% confidence interval (c.i.) were used as pooled effect size measures. The certainty of evidence was categorized with the GRADE framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 1152 patients from five RCTs were included; 34% underwent LL. Baseline demographics and pathological tumour stage were balanced among the LL and HL groups. At the 60-month follow-up, the OS and DFS estimates for LL versus HL were 1.40 months (95% c.i. \u22120.18 to 2.98; moderate level of certainty) and 0.71 months (95% c.i. \u22121.55 to 3.03; moderate level of certainty). Anastomotic leak (RR 0.71), overall complications (RR 0.79), total number of lymph nodes retrieved (SMD 0.01), and operating time (SMD 0.08) were comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta-analysis did not detect a statistically significant difference in 5-year OS and DFS between LL and HL in patients with rectosigmoid cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrag120","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:40:36Z","timestamp":1783856436000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of low\n                    <i>versus<\/i>\n                    high inferior mesenteric artery ligation in rectosigmoid cancer: individual patient data meta-analysis of randomized trials"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-6075","authenticated-orcid":false,"given":"Alberto","family":"Aiolfi","sequence":"first","affiliation":[{"name":"IRCCS Ospedale Galeazzi\u2014Sant\u2019Ambrogio Division of General Surgery, , Milan ,","place":["Italy"]},{"name":"University of Catania Department of Biomedical and Biotechnological Sciences, , Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-8485","authenticated-orcid":false,"given":"Francesco","family":"Cammarata","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Galeazzi\u2014Sant\u2019Ambrogio Division of General Surgery, , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-1783","authenticated-orcid":false,"given":"Emanuele","family":"Rausa","sequence":"additional","affiliation":[{"name":"Unit of Hereditary Digestive Tumors, Fondazione IRCCS\u2014National Cancer Institute , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Bonitta","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Galeazzi\u2014Sant\u2019Ambrogio Division of General Surgery, , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Biondi","sequence":"additional","affiliation":[{"name":"Surgical Division, Department of General Surgery and Medical Surgical Specialties, G. Rodolico Hospital, University of Catania , Catania ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-1670","authenticated-orcid":false,"given":"Luigi","family":"Bonavina","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutrition Sciences, Azienda Ospedaliera di Cosenza, Division of General and Foregut Surgery, University of Calabria , Cosenza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Bona","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Galeazzi\u2014Sant\u2019Ambrogio Division of General Surgery, , Milan ,","place":["Italy"]},{"name":"University of Milan Department of Biomedical Science for Health, , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"2026091106241796400_zrag120-B1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijsu.2017.12.030","article-title":"High tie versus low tie of the inferior mesenteric artery in colorectal cancer: a meta-analysis","volume":"52","author":"Yang","year":"2018","journal-title":"Int J Surg"},{"key":"2026091106241796400_zrag120-B2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00423-023-03022-z","article-title":"Inferior mesenteric artery ligation level in rectal cancer surgery: still no answer\u2014a systematic review and meta-analysis","volume":"408","author":"Cirocchi","year":"2023","journal-title":"Langenbecks Arch Surg"},{"key":"2026091106241796400_zrag120-B3","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00276-018-2092-3","article-title":"Neurovasculature of high and low tie ligation of the inferior mesenteric artery","volume":"40","author":"Campbell","year":"2018","journal-title":"Surg Radiol Anat"},{"key":"2026091106241796400_zrag120-B4","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s00464-021-08479-x","article-title":"Technical considerations depending on the level of vascular ligation in laparoscopic rectal resection","volume":"36","author":"Sokolov","year":"2022","journal-title":"Surg Endosc"},{"key":"2026091106241796400_zrag120-B5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/codi.15997","article-title":"Risk factors for anastomotic leakage after anterior resection for rectal cancer (RALAR study): a nationwide retrospective study of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative Group","volume":"24","author":"Degiuli","year":"2022","journal-title":"Colorectal Dis"},{"key":"2026091106241796400_zrag120-B6","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.ejso.2022.06.016","article-title":"A preoperative prediction model for anastomotic leakage after rectal cancer resection based on 13.175 patients","volume":"48","author":"Hoek","year":"2022","journal-title":"Eur J Surg Oncol"},{"key":"2026091106241796400_zrag120-B7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12957-018-1458-7","article-title":"High ligation of the inferior mesenteric artery during sigmoid colon and rectal cancer surgery increases the risk of anastomotic leakage: a meta-analysis","volume":"16","author":"Zeng","year":"2018","journal-title":"World J Surg Oncol"},{"key":"2026091106241796400_zrag120-B8","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1186\/s12885-025-14959-3","article-title":"The surgical effect of inferior mesenteric artery ligation level in rectal cancer and sigmoid colon cancer: a meta-analysis of randomized controlled trials","volume":"25","author":"You","year":"2025","journal-title":"BMC Cancer"},{"key":"2026091106241796400_zrag120-B9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12957-022-02741-9","article-title":"Does the level of inferior mesenteric artery ligation affect short-term and long-term outcomes of patients with sigmoid colon cancer or rectal cancer? A single-centre retrospective study","volume":"20","author":"Wang","year":"2022","journal-title":"World J Surg Oncol"},{"key":"2026091106241796400_zrag120-B10","doi-asserted-by":"crossref","first-page":"7798","DOI":"10.1007\/s00464-025-12123-3","article-title":"Modification of the vascular preparation after high tie ligation to improve colonic perfusion and increase the length of the colon limb in low anterior rectal resection","volume":"39","author":"Dittrich","year":"2025","journal-title":"Surg Endosc"},{"key":"2026091106241796400_zrag120-B11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00384-022-04101-1","article-title":"Systematic review and meta-analysis of randomized controlled trials evaluating the effect of the level of ligation of inferior mesenteric artery on functional outcomes in rectal cancer surgery","volume":"37","author":"Tryliskyy","year":"2022","journal-title":"Int J Colorectal Dis"},{"key":"2026091106241796400_zrag120-B12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000533407","article-title":"Level of inferior mesenteric artery ligation in sigmoid colon and rectal cancer surgery: analysis of apical lymph node metastasis and recurrence","volume":"40","author":"Nakamura","year":"2023","journal-title":"Dig Surg"},{"key":"2026091106241796400_zrag120-B13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/bjs5.71","article-title":"Randomized clinical trial of high versus low inferior mesenteric artery ligation during anterior resection for rectal cancer","volume":"2","author":"Fujii","year":"2018","journal-title":"BJS Open"},{"key":"2026091106241796400_zrag120-B14","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s00464-018-6363-1","article-title":"Short-term and long-term results of a randomized study comparing high tie and low tie inferior mesenteric artery ligation in laparoscopic rectal anterior resection: subanalysis of the HTLT (high tie vs. low tie) study","volume":"33","author":"Fujii","year":"2019","journal-title":"Surg Endosc"},{"key":"2026091106241796400_zrag120-B15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1245\/s10434-025-18642-6","article-title":"Low versus high ligation of inferior mesenteric artery in rectal and sigmoid cancers: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials","volume":"33","author":"Sassun","year":"2026","journal-title":"Ann Surg Oncol"},{"key":"2026091106241796400_zrag120-B16","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2026091106241796400_zrag120-B17","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"2026091106241796400_zrag120-B18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-Bias VISualization (Robvis): an R package and Shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2021","journal-title":"Res Synth Methods"},{"key":"2026091106241796400_zrag120-B19","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"2026091106241796400_zrag120-B20","author":"Sch\u00fcnemann"},{"key":"2026091106241796400_zrag120-B21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1471-2288-13-152","article-title":"Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome","volume":"13","author":"Royston","year":"2013","journal-title":"BMC Med Res Methodol"},{"key":"2026091106241796400_zrag120-B22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/bimj.201200152","article-title":"A matrix-based method of moments for fitting the multivariate random effects model for meta-analysis and meta-regression","volume":"55","author":"Jackson","year":"2013","journal-title":"Biom J"},{"key":"2026091106241796400_zrag120-B23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2288-12-9","article-title":"Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan\u2013Meier survival curves","volume":"12","author":"Guyot","year":"2012","journal-title":"BMC Med Res Methodol"},{"key":"2026091106241796400_zrag120-B24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/biostatistics\/kxz018","article-title":"Multivariate meta-analysis model for the difference in restricted mean survival times","volume":"22","author":"Weir","year":"2021","journal-title":"Biostatistics"},{"key":"2026091106241796400_zrag120-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v098.i14","article-title":"Mexhaz: an R package for fitting flexible hazard-based regression models for overall and excess mortality with a random effect","volume":"98","author":"Charvat","year":"2021","journal-title":"J Stat Softw"},{"key":"2026091106241796400_zrag120-B26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000477805","article-title":"Oncological outcomes following rectal cancer surgery with high or low ligation of the inferior mesenteric artery","volume":"4","author":"Matsuda","year":"2017","journal-title":"Gastrointest Tumors"},{"key":"2026091106241796400_zrag120-B27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ags3.12318","article-title":"Clinical impact of D3 lymph node dissection with left colic artery (LCA) preservation compared to D3 without LCA preservation: exploratory subgroup analysis of data from JCOG0404","volume":"4","author":"Akagi","year":"2020","journal-title":"Ann Gastroenterol Surg"},{"key":"2026091106241796400_zrag120-B28","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1002\/jso.26362","article-title":"High versus low ligation of the inferior mesenteric artery during laparoscopic rectal cancer surgery: a prospective study of surgical and oncological outcomes","volume":"123","author":"Feng","year":"2021","journal-title":"J Surg Oncol"},{"key":"2026091106241796400_zrag120-B29","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1111\/codi.15798","article-title":"Level of inferior mesenteric artery ligation does not affect rectal cancer treatment outcomes despite better cancer-specific survival after low ligation\u2014randomized trial results","volume":"23","author":"Kruszewski","year":"2021","journal-title":"Colorectal Dis"},{"key":"2026091106241796400_zrag120-B30","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ejso.2022.10.017","article-title":"5-Year oncological outcomes of the HIGHLOW randomized clinical trial","volume":"49","author":"Mari","year":"2023","journal-title":"Eur J Surg Oncol"},{"key":"2026091106241796400_zrag120-B31","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00384-019-03291-5","article-title":"Lymph node yield, survival benefit, and safety of high and low ligation of the inferior mesenteric artery in colorectal cancer surgery: a systematic review and meta-analysis","volume":"34","author":"Si","year":"2019","journal-title":"Int J Colorectal Dis"},{"key":"2026091106241796400_zrag120-B32","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000008520","article-title":"The long-term survival benefits of high and low ligation of inferior mesenteric artery in colorectal cancer surgery: a review and meta-analysis","volume":"96","author":"Singh","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"2026091106241796400_zrag120-B33","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1002\/sim.6556","article-title":"Meta-analysis of time-to-event outcomes from randomized trials using restricted mean survival time: application to individual participant data","volume":"34","author":"Wei","year":"2015","journal-title":"Stat Med"},{"key":"2026091106241796400_zrag120-B34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/annonc\/mdy462","article-title":"Interpretation of time-to-event outcomes in randomized trials: an online randomized experiment","volume":"30","author":"Weir","year":"2019","journal-title":"Ann Oncol"},{"key":"2026091106241796400_zrag120-B35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdy472","article-title":"Avoiding the hazards of misinterpreting treatment effects","volume":"30","author":"Saad","year":"2019","journal-title":"Ann Oncol"},{"key":"2026091106241796400_zrag120-B36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.6004\/jnccn.2024.0041","article-title":"NCCN Guidelines\u00ae insights: rectal cancer, version 3.2024","volume":"22","author":"Benson","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"key":"2026091106241796400_zrag120-B37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/bjs.9739","article-title":"Randomized clinical trial of defaecatory function after anterior resection for rectal cancer with high versus low ligation of the inferior mesenteric artery","volume":"102","author":"Matsuda","year":"2015","journal-title":"Br J Surg"},{"key":"2026091106241796400_zrag120-B38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.23922\/jarc.2025-071","article-title":"Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2024 for the clinical practice of inflammatory bowel disease-associated intestinal neoplasia (English version)","volume":"10","author":"Ishihara","year":"2026","journal-title":"J Anus Rectum Colon"},{"key":"2026091106241796400_zrag120-B39","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jnci\/93.8.583","article-title":"Guidelines 2000 for colon and rectal cancer surgery","volume":"93","author":"Nelson","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"2026091106241796400_zrag120-B40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00004836-199804000-00006","article-title":"Distribution of lymph node metastasis and level of inferior mesenteric artery ligation in colorectal cancer","volume":"26","author":"Adachi","year":"1998","journal-title":"J Clin Gastroenterol"},{"key":"2026091106241796400_zrag120-B41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1159\/000107779","article-title":"Impact of upward lymph node dissection on survival rates in advanced lower rectal carcinoma","volume":"24","author":"Uehara","year":"2007","journal-title":"Dig Surg"},{"key":"2026091106241796400_zrag120-B42","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/DCR.0000000000001693","article-title":"Meta-analysis and trial sequential analysis of randomized controlled trials comparing high and low ligation of the inferior mesenteric artery in rectal cancer surgery","volume":"63","author":"Hajibandeh","year":"2020","journal-title":"Dis Colon Rectum"},{"key":"2026091106241796400_zrag120-B43","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.2217\/fon-2021-0149","article-title":"Outcomes of level of ligation of inferior mesenteric artery in colorectal cancer: a systematic review and meta-analysis","volume":"17","author":"Jonnada","year":"2021","journal-title":"Future Oncol"},{"key":"2026091106241796400_zrag120-B44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1445-2197.2001.02204.x","article-title":"Consensus statement of definitions for anorectal physiology and rectal cancer","volume":"71","author":"Lowry","year":"2001","journal-title":"ANZ J Surg"},{"key":"2026091106241796400_zrag120-B45","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10350-004-0937-9","article-title":"Practice parameters for the management of rectal cancer (revised)","volume":"48","author":"Tjandra","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"2026091106241796400_zrag120-B46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/DCR.0b013e318246f1a2","article-title":"High tie versus low tie vascular ligation of the inferior mesenteric artery in colorectal cancer surgery: impact on the gain in colon length and implications on the feasibility of anastomoses","volume":"55","author":"Bonnet","year":"2012","journal-title":"Dis Colon Rectum"},{"key":"2026091106241796400_zrag120-B47","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/DCR.0000000000003669","article-title":"Impact of low ligation on bowel perfusion and anastomotic leakage in minimally invasive rectal cancer surgery: a post hoc analysis of a randomized controlled trial","volume":"68","author":"Kimura","year":"2025","journal-title":"Dis Colon Rectum"},{"key":"2026091106241796400_zrag120-B48","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/SLA.0000000000002947","article-title":"Low ligation of inferior mesenteric artery in laparoscopic anterior resection for rectal cancer reduces genitourinary dysfunction results from a randomized controlled trial (HIGHLOW trial)","volume":"269","author":"Mari","year":"2019","journal-title":"Ann Surg Open"},{"key":"2026091106241796400_zrag120-B49","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.21873\/anticanres.14276","article-title":"Defecatory dysfunction after colon cancer resection: the role of Inferior mesenteric artery tie","volume":"40","author":"Fiori","year":"2020","journal-title":"Anticancer Res"},{"key":"2026091106241796400_zrag120-B50","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00423-023-03026-9","article-title":"Impact on defecatory, urinary and sexual function after high-tie sigmoidectomy: a post-hoc analysis of a multicentre randomized controlled trial comparing extended versus standard complete mesocolon excision","volume":"408","author":"Planellas","year":"2023","journal-title":"Langenbecks Arch Surg"},{"key":"2026091106241796400_zrag120-B51","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.21873\/anticanres.14423","article-title":"Is low inferior mesenteric artery ligation worthwhile to prevent urinary and sexual dysfunction after total mesorectal excision for rectal cancer?","volume":"40","author":"Fiori","year":"2020","journal-title":"Anticancer Res"},{"key":"2026091106241796400_zrag120-B52","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/BF02055167","article-title":"Effect of high and intermediate ligation on survival and recurrence rates following curative resection of colorectal cancer","volume":"40","author":"Slanetz CA","year":"1997","journal-title":"Dis Colon Rectum"},{"key":"2026091106241796400_zrag120-B53","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/SLA.0000000000002947","article-title":"Low ligation of inferior mesenteric artery in laparoscopic anterior resection for rectal cancer reduces genitourinary dysfunction: results from a randomized controlled trial (HIGHLOW trial)","volume":"269","author":"Mari","year":"2019","journal-title":"Ann Surg"},{"key":"2026091106241796400_zrag120-B54","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1245\/s10434-023-13670-6","article-title":"Effect of anastomotic leak on long-term survival after esophagectomy: multivariate meta-analysis and restricted mean survival times examination","volume":"30","author":"Aiolfi","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"2026091106241796400_zrag120-B55","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jamasurg.2024.6729","article-title":"Validated integration of tumour deposits in N staging for prognostication in colon cancer","volume":"160","author":"Sassun","year":"2025","journal-title":"JAMA Surg"},{"key":"2026091106241796400_zrag120-B56","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/codi.14891","article-title":"Systematic review and meta-analysis of the anatomical variants of the left colic artery","volume":"22","author":"Cirocchi","year":"2020","journal-title":"Colorectal Dis"}],"container-title":["BJS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/10\/5\/zrag120\/71030651\/zrag120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/10\/5\/zrag120\/71030651\/zrag120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:24:28Z","timestamp":1789122268000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjsopen\/article\/doi\/10.1093\/bjsopen\/zrag120\/8790381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,4]]}},"URL":"https:\/\/doi.org\/10.1093\/bjsopen\/zrag120","relation":{},"ISSN":["2474-9842"],"issn-type":[{"value":"2474-9842","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,9,4]]},"article-number":"zrag120"}}